Aashish Choudhary
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View article: Improving psychological conditions in paediatric trauma hospitals via the trauma recovery and resilience program
Improving psychological conditions in paediatric trauma hospitals via the trauma recovery and resilience program Open
Pediatric trauma is a medical and psychological problem that is usually attributed to accidents, violence, or emergencies. Conventional trauma care places a strong emphasis on physical recovery, but it often ignores children's nervousness,…
View article: A Multidisciplinary Approach to Managing Pregnancy- Associated Spinal Schwannoma: Case Report of Neurological and Obstetric Challenges with Surgical Management
A Multidisciplinary Approach to Managing Pregnancy- Associated Spinal Schwannoma: Case Report of Neurological and Obstetric Challenges with Surgical Management Open
Spinal schwannomas are rare during pregnancy and pose unique diagnostic and therapeutic challenges, as their symptoms may mimic common gestational complaints. We report the case of a 28-year-old woman, gravida 3 para 2, who presented at 33…
View article: A comparison of effect of oral pre-medication with clonidine and metoprolol on intraoperative hemodynamics and surgical conditions during functional endoscopic sinus surgery 
A comparison of effect of oral pre-medication with clonidine and metoprolol on intraoperative hemodynamics and surgical conditions during functional endoscopic sinus surgery  Open
View article: Simple Clinical Presentation of a Complicated Disease: The Story of Two Women with MEN 1
Simple Clinical Presentation of a Complicated Disease: The Story of Two Women with MEN 1 Open
Background Multiple Endocrine Neoplasia Type 1 (MEN 1) is a rare hereditary disorder characterized by tumors in the parathyroid, pancreatic islet cells, and anterior pituitary. This study discusses two distinct clinical cases to illustrate…
View article: Dual-Task Gait and Balance Training Integrated With Sensory-Motor Interventions for Children With Autism Spectrum Disorder: A Comprehensive Narrative Review
Dual-Task Gait and Balance Training Integrated With Sensory-Motor Interventions for Children With Autism Spectrum Disorder: A Comprehensive Narrative Review Open
View article: Nephroprotective Role of Ichnocarpus frutescens Leaf Extract Against Cisplatin-Induced Renal Injury: Evidence from Rat and HK-2 Cell Models via Nrf2–HO-1–GPX4 Axis Modulation
Nephroprotective Role of Ichnocarpus frutescens Leaf Extract Against Cisplatin-Induced Renal Injury: Evidence from Rat and HK-2 Cell Models via Nrf2–HO-1–GPX4 Axis Modulation Open
Cisplatin is a widely prescribed chemotherapeutic drug, but its dose-dependent nephrotoxicity restricts therapeutic use and contributes substantially to treatment-related morbidity. The renal injury is mediated by oxidative stress, mitocho…
View article: Liraglutide-Metformin Combination Therapy in Type 2 Diabetes: A Comprehensive Review of Clinical Efficacy, Safety and Cost-Effectiveness
Liraglutide-Metformin Combination Therapy in Type 2 Diabetes: A Comprehensive Review of Clinical Efficacy, Safety and Cost-Effectiveness Open
Type 2 diabetes (T2D) presents a growing global health challenge, with escalating clinical and economic burdens driven largely by progressive disease and costly complications. This comprehensive review evaluates liraglutide combined with m…
View article: Optimization of Liposomal Formulations Using Design of Experiments (DOE) For Enhanced Skin Penetration of Anti-Aging Compounds
Optimization of Liposomal Formulations Using Design of Experiments (DOE) For Enhanced Skin Penetration of Anti-Aging Compounds Open
Liposomal drug delivery systems have been developed as a potential favourite to ameliorate the dermal delivery of the anti-aging substances because they are biocompatible, have the capacity to bind both hydrophilic and lipophilic drugs and…
View article: Triglyceride-Glucose Index Versus Glycated Albumin: Diagnostic Tools for Early Detection of Insulin Resistance and Pre-Diabetes
Triglyceride-Glucose Index Versus Glycated Albumin: Diagnostic Tools for Early Detection of Insulin Resistance and Pre-Diabetes Open
Background: Early detection of insulin resistance is essential for preventing type 2 diabetes and cardiovascular disease. Conventional methods like HOMA-IR rely on insulin assays, which may not be readily available in all clinical settings…
View article: Evaluation of intracranial pressure changes using ultrasonographic measurement of optic nerve sheath diameter during laparoscopic surgeries
Evaluation of intracranial pressure changes using ultrasonographic measurement of optic nerve sheath diameter during laparoscopic surgeries Open
Background & objective: Laparoscopic surgery, while minimally invasive, presents physiological challenges due to pneumoperitoneum and a Trendelenburg positioning, which may impact intracranial pressure (ICP). Optic nerve sheath diameter (O…
View article: Preventing Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Lifestyle, Exercise, and Pharmacologic Interventions
Preventing Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Lifestyle, Exercise, and Pharmacologic Interventions Open
Gestational diabetes mellitus (GDM) is associated with adverse maternal and neonatal outcomes and an increasing global prevalence. Preventive interventions during pregnancy may help mitigate these risks. This systematic review and meta-ana…
View article: Resource utilisation and cost of hospitalisation with community-acquired pneumonia among older adults in India, 2018–2020
Resource utilisation and cost of hospitalisation with community-acquired pneumonia among older adults in India, 2018–2020 Open
Introduction Community-acquired pneumonia (CAP) is an important cause of hospitalisation among older adults. Assessing costs of CAP hospitalisation aids in economic evaluation of preventive interventions and guides policy decisions. Method…
View article: Clinical profile and management of CMV retinitis in non-HIV subjects: A case series
Clinical profile and management of CMV retinitis in non-HIV subjects: A case series Open
This study aims to demonstrate the clinical presentations, diagnosis, and treatment modalities and outcomes for cytomegalovirus (CMV) retinitis in non-human immunodeficiency virus (HIV) immunocompromised states. HIV-seronegative patients t…
View article: Advances in familial hypercholesterolemia management: a systematic review of novel therapies and AI screening
Advances in familial hypercholesterolemia management: a systematic review of novel therapies and AI screening Open
Background. Familial hypercholesterolemia (FH) is a prevalent monogenic lipid disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) from birth, predisposing individuals to premature atherosclerotic cardiovascular d…
View article: Systemic lupus erythematosus and ANCA-associated vasculitis overlap with progressive interstitial lung disease: A narrative review with case illustration
Systemic lupus erythematosus and ANCA-associated vasculitis overlap with progressive interstitial lung disease: A narrative review with case illustration Open
Background. Overlap syndromes involving systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV) are increasingly recognized but remain diagnostically and therapeutically challenging – especially when complicated by progress…
View article: Disseminated granulomatous disease: TB or sarcoidosis – a diagnostic and therapeutic challenge
Disseminated granulomatous disease: TB or sarcoidosis – a diagnostic and therapeutic challenge Open
The overlapping clinical presentation of tuberculosis (TB) and sarcoidosis presents a significant diagnostic and therapeutic challenge, particularly in TB-endemic regions. This case study reports a 52-year-old female presenting with dissem…
View article: Influence of BIS monitoring, obesity severity, and anesthetic agents on recovery outcomes in obese patients undergoing laparoscopic surgery: a multivariate analysis
Influence of BIS monitoring, obesity severity, and anesthetic agents on recovery outcomes in obese patients undergoing laparoscopic surgery: a multivariate analysis Open
Background & objective: Bispectral Index (BIS) monitoring is widely used to optimize anesthetic depth, but its impact on perioperative recovery outcomes in obese patients undergoing laparoscopic surgery remains unclear. This study evaluate…
View article: A clinical comparison of oral midazolam vs. midazolam-ketamine for premedication in pediatric patients undergoing elective surgeries: efficacy and safety assessment
A clinical comparison of oral midazolam vs. midazolam-ketamine for premedication in pediatric patients undergoing elective surgeries: efficacy and safety assessment Open
Background & objective: Preoperative anxiety in pediatric patients is associated with poor cooperation, increased anesthetic requirements, and adverse postoperative outcomes. Oral premedication with midazolam is common, but its effectivene…
View article: Clinical management and outcomes of snake envenomation: a case series: Snake Envenomation: A Case Series
Clinical management and outcomes of snake envenomation: a case series: Snake Envenomation: A Case Series Open
Introduction. In tropical rural communities, snakebite envenomation is among the main causes of morbidity and mortality. It results in shock, hemorrhage, tissue necrosis, and swelling. Diagnosing and identifying snake species is challengin…
View article: Incidence of respiratory viral infections in adults following hematopoietic stem cell transplant (HSCT) at a tertiary care hospital in India
Incidence of respiratory viral infections in adults following hematopoietic stem cell transplant (HSCT) at a tertiary care hospital in India Open
View article: Artificial Intelligence in Sports Science: A Systematic Review on Performance Optimization, Injury Prevention, and Rehabilitation
Artificial Intelligence in Sports Science: A Systematic Review on Performance Optimization, Injury Prevention, and Rehabilitation Open
Background: Artificial intelligence (AI) is quickly revolutionizing sports science, providing researchers and practitioners with new means to support the optimization of performance, the improvement of rehabilitation, and the preven…
View article: Rehabilitation across the Spectrum: A Case Series Evaluating a Structured Program for Knee Osteoarthritis and Musculoskeletal Impairments
Rehabilitation across the Spectrum: A Case Series Evaluating a Structured Program for Knee Osteoarthritis and Musculoskeletal Impairments Open
Knee osteoarthritis and related musculoskeletal conditions significantly impact mobility and independence in older adults. This prospective case series evaluated a 12-week structured physiotherapy program in five elderly women with diverse…
View article: Hematological manifestations of undiagnosed tuberculosis: a report of two rare cases
Hematological manifestations of undiagnosed tuberculosis: a report of two rare cases Open
Background. Tuberculosis (TB) is a prevalent infectious disease with diverse clinical manifestations. Hematological abnormalities, though uncommon, can present as primary features of TB, complicating its diagnosis and management. These aty…
View article: Optimizing care for women experiencing pregnancy loss: Insights from a systematic review and meta-analysis
Optimizing care for women experiencing pregnancy loss: Insights from a systematic review and meta-analysis Open
Background Pregnancy loss, including miscarriage, stillbirth, and early losses, affects millions globally. Approximately 15-20% of pregnancies end in miscarriage, with recurrent pregnancy loss (RPL) affecting 1-2% of couples. This systemat…
View article: Ultrasound assessment of the sciatic nerve depth and its relationship with anthropometric parameters
Ultrasound assessment of the sciatic nerve depth and its relationship with anthropometric parameters Open
Background & objective: Sciatic nerve blocks under ultrasound guidance serve as fundamental procedures for lower limb anesthesia because they provide better safety and accuracy. The procedural outcome depends on sciatic nerve depth variati…
View article: Beyond One-Size-Fits-All: A Systematic Review of Genetic, Epigenetic, and Microbiome Contributions to Drug Action with AI Applications
Beyond One-Size-Fits-All: A Systematic Review of Genetic, Epigenetic, and Microbiome Contributions to Drug Action with AI Applications Open
Background: Drug response variability is influenced by multiple biological and computational factors, including pharmacogenomics, epigenetics, gut microbiota, and artificial intelligence (AI). Understanding these factors is crucial for opt…
View article: Effect of injection speed of hyperbaric bupivacaine 0.5% in spinal anesthesia on block quality and hemodynamic changes in elective cesarean sections
Effect of injection speed of hyperbaric bupivacaine 0.5% in spinal anesthesia on block quality and hemodynamic changes in elective cesarean sections Open
Background: Spinal anesthesia (SA) with hyperbaric bupivacaine 0.5% is a standard technique for lower segment cesarean sections (LSCS). However, the impact of injection speed on block quality, hemodynamic stability, and recovery remains un…
View article: Comparative study of clonidine and fentanyl as adjuvants to ropivacaine in spinal anesthesia: impact on analgesic efficacy, hemodynamic stability, and adverse effects
Comparative study of clonidine and fentanyl as adjuvants to ropivacaine in spinal anesthesia: impact on analgesic efficacy, hemodynamic stability, and adverse effects Open
Background & objective: Spinal anesthesia is commonly used for lower limb and abdominal surgeries, but its effectiveness is limited by the duration of action of local anesthetics. To prolong analgesia and improve intraoperative conditions,…
View article: Persistent Pyrexia of Unknown Origin and Deep Vein Thrombosis in a Patient with Sjögren’s Syndrome: A Case Report
Persistent Pyrexia of Unknown Origin and Deep Vein Thrombosis in a Patient with Sjögren’s Syndrome: A Case Report Open
View article: An in-depth analysis of the benefits of musical therapies for people with dementia
An in-depth analysis of the benefits of musical therapies for people with dementia Open
To ascertain which actions, therapists, and participant characteristics had more potent and perceptible effects, a meta-analysis of illegal research on the impact of music rehabilitation on disorderly behaviors, nervousness levels, miserab…