Aashish R. Jha
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View article: The Emirati Genome Program Enables Population-wide Penetrance Estimation and Novel Discovery for Inherited Retinal Disease
The Emirati Genome Program Enables Population-wide Penetrance Estimation and Novel Discovery for Inherited Retinal Disease Open
Interpreting rare variants remains a major challenge in genomic medicine, particularly for genetically and phenotypically heterogeneous disorders like inherited retinal diseases (IRDs). We introduce a population-scale framework that unites…
View article: Ecological factors that drive microbial communities in culturally diverse fermented foods
Ecological factors that drive microbial communities in culturally diverse fermented foods Open
Background Fermented foods are increasingly recognized for their health benefits. Historically, cultures worldwide have relied on fermentation to preserve foods and enhance their digestibility, flavor, aromas, and taste. Despite the abunda…
View article: Passive intestinal microbiome sampling using an ingestible device with tortuous lattices
Passive intestinal microbiome sampling using an ingestible device with tortuous lattices Open
View article: Integrative multi-omic analysis reveals oral microbiome-metabolome signatures of obesity
Integrative multi-omic analysis reveals oral microbiome-metabolome signatures of obesity Open
Obesity is a major global health challenge and a leading risk factor for cardiometabolic disorders. The global surge in obesity, driven by industrialization and the widespread consumption of low-fiber, ultra-processed food, highlights an u…
View article: Women-driven community education in Nepal
Women-driven community education in Nepal Open
View article: Correction: Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized
Correction: Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized Open
View article: Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized
Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized Open
Background Lifestyle plays an important role in shaping the gut microbiome. However, its contributions to the oral microbiome remain less clear, due to the confounding effects of geography and methodology in investigations of populations s…
View article: Ecological factors that drive microbial communities in culturally diverse fermented foods
Ecological factors that drive microbial communities in culturally diverse fermented foods Open
Fermented foods are increasingly recognized for their health benefits. Historically, cultures worldwide have relied on fermentation to preserve foods and enhance their digestibility, flavor, aromas, and taste. Despite the abundance of glob…
View article: Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized
Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized Open
Background: Lifestyle plays an important role in shaping the gut microbiome. However, its contributions to the oral microbiome remains less clear, due to the confounding effects of geography and methodology in investigations of populations…
View article: Falcon gut microbiota is shaped by diet and enriched in Salmonella
Falcon gut microbiota is shaped by diet and enriched in Salmonella Open
The gut microbiome is increasingly being appreciated as a master regulator of animal health. However, avian gut microbiome studies commonly focus on birds of economic importance and the gut microbiomes of raptors remain underexplored. Here…
View article: Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes
Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes Open
View article: Remote PPG vital sign Estimation with adaptive facial regions
Remote PPG vital sign Estimation with adaptive facial regions Open
Traditional research in the automatic recognition of human emotions has relied on the use of body-placed sensors to collect physiological data. However, recent studies have revealed that heart rate estimation can be derived from video foot…
View article: Dietary enrichment of resistant starches or fibers differentially alter the feline fecal microbiome and metabolite profile
Dietary enrichment of resistant starches or fibers differentially alter the feline fecal microbiome and metabolite profile Open
Background Cats are strict carnivores but possess a complex gastrointestinal (GI) microbial community that actively ferments dietary substrates that are not digested and reach the colon. The GI microbiota responses to dietary inclusion of …
View article: Falcon gut microbiome is shaped by diet and enriched in<i>Salmonella</i>
Falcon gut microbiome is shaped by diet and enriched in<i>Salmonella</i> Open
The gut microbiome is increasingly being appreciated as a master regulator of animal health. However, most avian gut microbiome studies have focused on birds of economic importance while the gut microbiomes of raptors remain underexplored.…
View article: Network-based gut microbiome analysis in dogs
Network-based gut microbiome analysis in dogs Open
A growing number of studies in the last decade described the microbial populations in different niches of the organism thank to High-throughput DNA sequencing techniques, that are easily accessible to researchers. Furthermore, network anal…
View article: Longitudinal fecal microbiome and metabolite data demonstrate rapid shifts and subsequent stabilization after an abrupt dietary change in healthy adult dogs
Longitudinal fecal microbiome and metabolite data demonstrate rapid shifts and subsequent stabilization after an abrupt dietary change in healthy adult dogs Open
Background Diet has a large influence on gut microbiota diversity and function. Although previous studies have investigated the effect of dietary interventions on the gut microbiome, longitudinal changes in the gut microbiome, microbial fu…
View article: Robust variation in infant gut microbiome assembly across a spectrum of lifestyles
Robust variation in infant gut microbiome assembly across a spectrum of lifestyles Open
Infant microbiome assembly has been intensely studied in infants from industrialized nations, but little is known about this process in nonindustrialized populations. We deeply sequenced infant stool samples from the Hadza hunter-gatherers…
View article: Robust Variation in Infant Gut Microbiome Assembly Across a Spectrum of Lifestyles
Robust Variation in Infant Gut Microbiome Assembly Across a Spectrum of Lifestyles Open
Infant microbiome assembly is intensely studied in infants from industrialized nations, but little is known about this process in populations living non-industrialized lifestyles. In this study we deeply sequenced infant stool samples from…
View article: Ultra-deep Sequencing of Hadza Hunter-Gatherers Recovers Vanishing Gut Microbes
Ultra-deep Sequencing of Hadza Hunter-Gatherers Recovers Vanishing Gut Microbes Open
Summary The gut microbiome is a key modulator of immune and metabolic health. Human microbiome data is biased towards industrialized populations, providing limited understanding of the distinct and diverse non-industrialized microbiomes. H…
View article: Prevalence and determinants of hypertension in underrepresented indigenous populations of Nepal
Prevalence and determinants of hypertension in underrepresented indigenous populations of Nepal Open
Indigenous populations residing in low- and middle-income countries (LMICs) are highly underrepresented in medicine and public health research. Specifically, data on non-communicable diseases (NCDs) from indigenous populations remains scar…
View article: Human Gut Microbes Associated with Systolic Blood Pressure
Human Gut Microbes Associated with Systolic Blood Pressure Open
Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbi…
View article: Network-based gut microbiome analysis in dogs
Network-based gut microbiome analysis in dogs Open
A growing number of studies in the last decade described the microbial populations in different niches of the organism thank to High-throughput DNA sequencing techniques, that are easily accessible to researchers. Furthermore, network anal…
View article: Peer Review #1 of "Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet (v0.1)"
Peer Review #1 of "Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet (v0.1)" Open
Background: The gut microbiota (GM) is associated with canine health and can be impacted by diet.Dog owners in the U.S. have increasingly shown an interest in feeding their dogs a mildly cooked (MC) diet.However, its impact on canine GM an…
View article: Peer Review #3 of "Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet (v0.1)"
Peer Review #3 of "Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet (v0.1)" Open
Background: The gut microbiota (GM) is associated with canine health and can be impacted by diet.Dog owners in the U.S. have increasingly shown an interest in feeding their dogs a mildly cooked (MC) diet.However, its impact on canine GM an…
View article: Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet
Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet Open
Background The gut microbiota (GM) is associated with canine health and can be impacted by diet. Dog owners in the U.S. have increasingly shown an interest in feeding their dogs a mildly cooked (MC) diet. However, its impact on canine GM a…
View article: Peer Review #3 of "Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet (v0.2)"
Peer Review #3 of "Heterogeneity of gut microbial responses in healthy household dogs transitioning from an extruded to a mildly cooked diet (v0.2)" Open
Background: The gut microbiota (GM) is associated with canine health and can be impacted by diet.Dog owners in the U.S. have increasingly shown an interest in feeding their dogs a mildly cooked (MC) diet.However, its impact on canine GM an…
View article: The microbiota of healthy dogs demonstrates individualized responses to synbiotic supplementation in a randomized controlled trial
The microbiota of healthy dogs demonstrates individualized responses to synbiotic supplementation in a randomized controlled trial Open
View article: Gut microbes in healthy dogs have individualized responses to synbiotic supplementation that lead to increased abundances of probiotic strains: A randomized controlled trial
Gut microbes in healthy dogs have individualized responses to synbiotic supplementation that lead to increased abundances of probiotic strains: A randomized controlled trial Open
Background: Probiotics ameliorate gastrointestinal symptoms in dogs. However, the effect of probiotics in a healthy population, as well as factors contributing individualized responses, remains largely unknown. This trial examined gut micr…
View article: The Effect of Probiotics Supplementation on the Gut Microbiome of Healthy Dogs Assessed Using Metagenomic Sequencing: A Randomized Control Trial
The Effect of Probiotics Supplementation on the Gut Microbiome of Healthy Dogs Assessed Using Metagenomic Sequencing: A Randomized Control Trial Open
OBJECTIVES: Dogs share similar gut microbiome (GM) with humans, making them a great model for investigating the effects of probiotics (PR) on GM and health. This randomized control trial examined changes in MB and health outcomes in househ…
View article: Risk factors associated with canine overweightness and obesity in an owner-reported survey
Risk factors associated with canine overweightness and obesity in an owner-reported survey Open
Background : Overweightness and obesity in dogs are associated with negative health outcomes. A better understanding of risk factors associated with canine weight is fundamental to identifying preventative interventions and treatments. In …