Aashit Shah
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View article: Status Epilepticus Protocol Variation Across Accredited National Association of Epilepsy Centers Members
Status Epilepticus Protocol Variation Across Accredited National Association of Epilepsy Centers Members Open
Despite the importance of timeliness in SE management, one third of institutional protocols did not specify treatment times. This analysis of US hospital inpatient SE protocols provides expert opinion regarding infusion therapy management …
View article: Investigation of Electroencephalographic (EEG) Brainwave Signal on Mental Stress through Psychomotor Activities
Investigation of Electroencephalographic (EEG) Brainwave Signal on Mental Stress through Psychomotor Activities Open
Mental well-being plays a crucial aspect in human life alongside physical health. A positive mental health allows individuals to engage in healthy relationship, navigate challenges in a positive manner and enjoys a sense of fulfilment upon…
View article: Posterior Reversible Encephalopathy Syndrome Following Cesarean Section
Posterior Reversible Encephalopathy Syndrome Following Cesarean Section Open
Posterior Reversible Encephalopathy Syndrome (PRES) is a complex neurological disorder characterized by diverse clinical manifestations and potentially severe complications, particularly in the peripartum period. We present a case of a 23-…
View article: Management of Severe Dyselectrolytemia in an Elderly Patient with Normal Pressure Hydrocephalus
Management of Severe Dyselectrolytemia in an Elderly Patient with Normal Pressure Hydrocephalus Open
Dyselectrolytemia represents a significant clinical challenge, particularly in elderly patients with comorbid conditions. We present a case of a 72-year-old male with known normal pressure hydrocephalus (NPH) who presented with acute sympt…
View article: A Case Report of Bacterial Meningoencephalitis with Altered Sensorium in a 50-Year-Old Male
A Case Report of Bacterial Meningoencephalitis with Altered Sensorium in a 50-Year-Old Male Open
Bacterial meningoencephalitis remains a significant cause of morbidity and mortality worldwide, requiring prompt diagnosis and treatment. We present a case of a 50-year-old male who presented to the emergency room with a three-day history …
View article: Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy
Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy Open
Importance Many patients with focal epilepsy experience seizures despite treatment with currently available antiseizure medications (ASMs) and may benefit from novel therapeutics. Objective To evaluate the efficacy and safety of XEN1101, a…
View article: Neurotoxicity from intrathecal gadolinium administration
Neurotoxicity from intrathecal gadolinium administration Open
Intrathecal administration of gadolinium may result in catastrophic neurologic injury. Policies that prevent accidental injection of high-dose intrathecal gadolinium should be advocated.
View article: Bruxism
Bruxism Open
A 32-year-old man presents with intractable right temporal lobe epilepsy of currently unknown etiology described as focal unaware seizures with teeth grinding and rhythmic left leg movements with and without spread to bilateral tonic-cloni…
View article: Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients
Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients Open
Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 and DCR2 and assesses …
View article: Amyloid spells
Amyloid spells Open
A 66-year-old woman presented with a history of recurrent, transient neurologic symptoms including limb shaking, focal paresthesias, focal weakness, dysphasia, and unresponsiveness. The episodes showed no preference for time of day, lasted…
View article: Tolerability of adjunctive eslicarbazepine acetate according to concomitant lamotrigine or carbamazepine use: A subgroup analysis of three phase III trials in adults with focal (partial-onset) seizures
Tolerability of adjunctive eslicarbazepine acetate according to concomitant lamotrigine or carbamazepine use: A subgroup analysis of three phase III trials in adults with focal (partial-onset) seizures Open
There was a potential pharmacodynamic interaction between AEDs with a putatively similar mechanism of action, with a seemingly lesser interaction between ESL and LTG versus ESL and CBZ. If combining ESL with LTG or CBZ, clinicians should b…
View article: Inadequate benzodiazepine dosing may result in progression to refractory and non‐convulsive status epilepticus
Inadequate benzodiazepine dosing may result in progression to refractory and non‐convulsive status epilepticus Open
Aims . Status epilepticus (SE) is defined as ongoing seizures lasting longer than five minutes or multiple seizures without recovery. Benzodiazepines (BZDs) are first‐line agents for the management of SE. Our objective was to evaluate BZD …
View article: Psychiatric and cognitive adverse events: A pooled analysis of three phase III trials of adjunctive eslicarbazepine acetate for partial-onset seizures
Psychiatric and cognitive adverse events: A pooled analysis of three phase III trials of adjunctive eslicarbazepine acetate for partial-onset seizures Open
In phase III clinical trials of adjunctive ESL for treatment-refractory POS, psychiatric and cognitive TEAEs were reported infrequently with ESL and placebo. The incidences of depression and suicidality-related TEAEs and of cognitive TEAEs…
View article: Updates in Refractory Status Epilepticus
Updates in Refractory Status Epilepticus Open
Refractory status epilepticus is defined as persistent seizures despite appropriate use of two intravenous medications, one of which is a benzodiazepine. It can be seen in up to 40% of cases of status epilepticus with an acute symptomatic …
View article: Three- and four-dimensional mapping of speech and language in patients with epilepsy
Three- and four-dimensional mapping of speech and language in patients with epilepsy Open
We have provided 3-D and 4D mapping of speech and language function based upon the results of direct cortical stimulation and event-related modulation of electrocorticography signals. Patients estimated to have right-hemispheric language d…
View article: Management of brain tumor-related epilepsy
Management of brain tumor-related epilepsy Open
Seizures are common in both primary and metastatic brain tumors, although the rate of seizures differ significantly between the different types of neoplasms. Patients with brain tumor-associated seizures need treatment with antiepileptic d…
View article: Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials
Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials Open
Patients with low-grade glioma frequently have brain tumor-related epilepsy, which is more common than in patients with high-grade glioma. Treatment for tumor-associated epilepsy usually comprises a combination of surgery, anti-epileptic d…