Aastha Takkar
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View article: Diagnostic Potential of Cerebrospinal Fluid Biomarkers in Diagnosis of Primary Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis
Diagnostic Potential of Cerebrospinal Fluid Biomarkers in Diagnosis of Primary Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis Open
Background: Primary central nervous system lymphoma (PCNSL) is an aggressive form of non-Hodgkin’s lymphoma primarily restricted to the brain, spinal cord, eyes, and leptomeninges without any evidence of systemic spread. It is often challe…
View article: Bridging the Heart and Mind: A Gendered Lens On Post-MI Recovery
Bridging the Heart and Mind: A Gendered Lens On Post-MI Recovery Open
View article: The Neuro-Ophthalmology of Tuberculosis
The Neuro-Ophthalmology of Tuberculosis Open
Tuberculosis (TB) is a global health concern and central nervous system (CNS) TB leads to high mortality and morbidity. CNS TB can manifest as tubercular meningitis, tuberculoma, myelitis, and arachnoiditis. Neuro-ophthalmological involvem…
View article: Tonic down-rolling and eccentric down-positioning of eyes under sevoflurane anesthesia without non-depolarizing muscle relaxant and its relationship with depth of anesthesia
Tonic down-rolling and eccentric down-positioning of eyes under sevoflurane anesthesia without non-depolarizing muscle relaxant and its relationship with depth of anesthesia Open
Purpose To analyze the relationship between eccentric downward eye movement/eccentric downward eye-positioning (EDEM/EDEP) encountered in patients undergoing ophthalmic surgeries and its return to a centralized position under general anest…
View article: Clinical Profile of Patients with Leber Hereditary Optic Neuropathy—An Ambispective Study in Cohort from Northern Part of India
Clinical Profile of Patients with Leber Hereditary Optic Neuropathy—An Ambispective Study in Cohort from Northern Part of India Open
Dear Editor in Chief We thank the authors for their keen interest in our article. Ample data on Leber hereditary optic neuropathy (LHON) has been described from the west. However, systematic literature on LHON from the Indian subcontinent …
View article: Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population
Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population Open
Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-ind…
View article: Neuroophthalmology - A Time to Revive Clinical Skills
Neuroophthalmology - A Time to Revive Clinical Skills Open
View article: The Genetics of Ethambutol-Induced Optic Neuropathy: A Narrative Review
The Genetics of Ethambutol-Induced Optic Neuropathy: A Narrative Review Open
Tuberculosis (TB) is a global health problem with the major brunt of disease occurring in developing countries. The cornerstone of treatment of TB is anti-tubercular therapy (ATT), which includes rifampicin, isoniazid, pyrazinamide and eth…
View article: Tonic down-rolling and eccentric down-positioning of eyes under general anaesthesia: Case series and review of Literature
Tonic down-rolling and eccentric down-positioning of eyes under general anaesthesia: Case series and review of Literature Open
Background. Unexpected tonic down-rolling and eccentric down-positioning of eyes during general anesthesia can have serious implications in ocular surgeries . Objectives . To summarize abrupt eccentric eye positioning in downgaze following…
View article: Report of plasma exchange in a rare case of association of myasthenia gravis with thymoma and parathyroid adenoma
Report of plasma exchange in a rare case of association of myasthenia gravis with thymoma and parathyroid adenoma Open
Myasthenia with thymoma and parathyroid adenoma is a rare presentation. Very few cases have been reported of this association without much role of plasma exchange in these patients. Here, we present our experience of plasma exchange in thi…
View article: Erythema nodosum, zoster duplex and pityriasis rosea as possible cutaneous adverse effects of Oxford–AstraZeneca COVID‐19 vaccine: report of three cases from India
Erythema nodosum, zoster duplex and pityriasis rosea as possible cutaneous adverse effects of Oxford–AstraZeneca COVID‐19 vaccine: report of three cases from India Open
As a response to the coronavirus disease (COVID-19) pandemic, several vaccines have been developed globally and are being rolled out at a fast pace for public immunization. Drug controller general of India has approved use of Covaxin™ (BBV…
View article: Successful Use of High Dose Methotrexate in Treatment of Primary CNS Lymphoma Patients Without Access to Serum Methotrexate Levels Monitoring: Challenges and Outcome
Successful Use of High Dose Methotrexate in Treatment of Primary CNS Lymphoma Patients Without Access to Serum Methotrexate Levels Monitoring: Challenges and Outcome Open
View article: Magnetic resonance imaging (MRI) versus computed tomographic scan (CT scan) of brain in evaluation of suspected cavernous sinus syndrome
Magnetic resonance imaging (MRI) versus computed tomographic scan (CT scan) of brain in evaluation of suspected cavernous sinus syndrome Open
Background and purpose The cavernous sinus is a unique region owing to anatomical factors and the pathologies affecting it. The diagnosis of cavernous sinus syndrome (CSS) predominantly relies on clinicoradiological correlation. We studied…
View article: Mimics of Optic Neuritis in Neuromyelitis Optica Spectrum Disorder: A Case Report
Mimics of Optic Neuritis in Neuromyelitis Optica Spectrum Disorder: A Case Report Open
The optic nerve can be involved in a myriad of pathologies underscoring the importance of ruling out both surgical as well as medical causes. Often, it is the temporal profile, clinical presentation and imaging that helps to establish the …
View article: Non-Arteritic Anterior Ischaemic Optic Neuropathy – Myths and Misconceptions: Experience from a Tertiary Care Centre in North India
Non-Arteritic Anterior Ischaemic Optic Neuropathy – Myths and Misconceptions: Experience from a Tertiary Care Centre in North India Open
We prospectively evaluated 22 consecutive patients (24 eyes) suffering from non-arteritic anterior ischaemic optic neuropathy (NAION) at a tertiary care centre in Northern India. The mean age was 51.7 years. Visual loss on awakening was no…
View article: Acute Nontraumatic Muscle Weakness
Acute Nontraumatic Muscle Weakness Open
Acute nontraumatic weakness (ANTW) is defined as acute onset of weakness in any part of the body. The weakness occurs due to interruption at any point along the motor pathway. The motor pathway originates from upper motor neuron cells in t…
View article: Proteome-wide characterization and biomarker identification of intracranial aneurysm
Proteome-wide characterization and biomarker identification of intracranial aneurysm Open
The scientific basis of intracranial aneurysm (IA) formation, its rupture and further development of cerebral vasospasm remains incompletely understood. Deciphering the molecular mechanisms underlying these events will lead to identificati…
View article: Neuromyelitis optica spectrum disorder and adenocarcinoma of ovary: a novel association
Neuromyelitis optica spectrum disorder and adenocarcinoma of ovary: a novel association Open
Paraneoplastic neuromyelitis optica spectrum disorder (NMOSD) is a rare clinical entity with less than 40 cases described in literature until today. Paraneoplastic NMOSD in association with adenocarcinoma of ovary has not been described ye…
View article: Rapidly progressive dementia: an unusual cause
Rapidly progressive dementia: an unusual cause Open
Brain metastases are known to be present with a history of increased intra-cranial pressure headache, seizures or altered sensorium. Corresponding to the clinical brain metastases are the most feared complication of a systemic cancer. Clas…
View article: Infiltrative Optic Neuropathies: Opening Doors to Sinister Pathologies
Infiltrative Optic Neuropathies: Opening Doors to Sinister Pathologies Open
Optic disc edema may be caused by a number of conditions. A commonly ignored but important aspect is the presence of "infiltration" of disc; that may closely mimic disc edema. Disc edema, optic nerve dysfunction and a normal appearing disc…
View article: Focal gigantism in tuberous sclerosis
Focal gigantism in tuberous sclerosis Open
A 38 year lady had recurrent generalized and myoclonic seizures since 6 years of age. On examination she had facial adenoma sebaceum and periungal fibromas, cutaneous angiofibromas on the back. Contrast enhanced magnetic Resonance Imaging …
View article: Combined central retinal artery and vein occlusion with optic perineuritis following herpes zoster dermatitis in an immunocompetent child
Combined central retinal artery and vein occlusion with optic perineuritis following herpes zoster dermatitis in an immunocompetent child Open
A 15-year-old healthy boy developed acute, rapidly progressing visual loss in left eye following herpes zoster dermatitis, with a combined central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO), along with optic …
View article: Which Classification of Cavernous Sinus Syndrome is Better - Ishikawa or Jefferson? A Prospective Study of 73 Patients
Which Classification of Cavernous Sinus Syndrome is Better - Ishikawa or Jefferson? A Prospective Study of 73 Patients Open
Introduction: Ishikawa and Jefferson are the two most commonly used systems used for the classification of cavernous sinus syndrome (CSS). However, relative utilities of these two classification systems have not been evaluated in detail in…
View article: Kinked carotids: The "python" in the neck
Kinked carotids: The "python" in the neck Open