Aayush Kant
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View article: Long-term physiological flow rescues regressed microvascular networks and increases their longevity
Long-term physiological flow rescues regressed microvascular networks and increases their longevity Open
The incorporation of a functional perfusable microvascular network (MVN) is a common requirement for most organ on-chip-models. Long-term perfusion of MVNs is often required for the maturation of organ phenotypes and disease pathologies an…
View article: O-SNAP: A comprehensive pipeline for spatial profiling of chromatin architecture
O-SNAP: A comprehensive pipeline for spatial profiling of chromatin architecture Open
We present O-SNAP (Objective Single-Molecule Nuclear Architecture Profiler), a comprehensive pipeline for the automated extraction, comparison, and classification of nuclear features from single-molecule localization microscopy (SMLM) data…
View article: Remodeling of self-assembled microvascular networks under long term flow
Remodeling of self-assembled microvascular networks under long term flow Open
The incorporation of a functional perfusable microvascular network (MVN) is a common requirement for most organ on-chip-models. Long-term perfusion of MVNs is often required for the maturation of organ phenotypes and disease pathologies an…
View article: Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging
Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging Open
The interactions between chromatin and the nuclear lamina orchestrate cell type-specific gene activity by forming lamina-associated domains (LADs) which preserve cellular characteristics through gene repression. However, unlike the interac…
View article: Chemo-Mechanical Regulation of Tau Phosphorylation Following Traumatic Brain Injuries
Chemo-Mechanical Regulation of Tau Phosphorylation Following Traumatic Brain Injuries Open
Traumatic brain injuries are characterized by damage to axonal cytoskeletal proteins. Here, we present a mathematical model predicting the chemo-mechanical disruption of intra-axonal micro-tubule assembly in terms of hyperphosphorylation-l…
View article: Active Transcription and Epigenetic Reactions Synergistically Regulate Meso-Scale Genomic Organization
Active Transcription and Epigenetic Reactions Synergistically Regulate Meso-Scale Genomic Organization Open
In interphase nuclei, chromatin is organized into interspersed dense domains with characteristic sizes, both in the nuclear interior and periphery. However, the quantitative impact of transcription and histone modifications on the size and…
View article: Lipid droplets are intracellular mechanical stressors that impair hepatocyte function
Lipid droplets are intracellular mechanical stressors that impair hepatocyte function Open
Matrix stiffening and external mechanical stress have been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular …
View article: Lipid droplets are intracellular mechanical stressors that promote hepatocyte dedifferentiation
Lipid droplets are intracellular mechanical stressors that promote hepatocyte dedifferentiation Open
Matrix stiffening and external mechanical stress have been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular …
View article: Modeling links softening of myelin and spectrin scaffolds of axons after a concussion to increased vulnerability to repeated injuries
Modeling links softening of myelin and spectrin scaffolds of axons after a concussion to increased vulnerability to repeated injuries Open
Significance Growing evidence from in vitro studies suggests that the axonal cytoskeleton plays a mechanoprotective role in axon while under dynamic mechanical loads during a traumatic brain injury (TBI). Via computational modeling, we elu…
View article: Stress Driven Physiological Damage After Traumatic Brain Injuries
Stress Driven Physiological Damage After Traumatic Brain Injuries Open
Development of a mathematical tool to predict the biomechanical damage in the secondary insult phase of a traumatic brain injury constitutes an important step in its prevention and clinical treatment. Secondary injuries are initiated by an…
View article: EPA volume 50 Cover and Front matter
EPA volume 50 Cover and Front matter Open
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