Abasalt Hosseinzadeh Colagar
YOU?
Author Swipe
View article: Uncovering the protein aggregation process through effect of G41D mutant SOD1 charge variation in ALS disease
Uncovering the protein aggregation process through effect of G41D mutant SOD1 charge variation in ALS disease Open
Neurodegenerative disorders are a group of hereditary and sporadic conditions that are characterized by progressive nervous system dysfunctions. Mutations in the gene encoding human superoxide dismutase 1 (hSOD1) were among the first to be…
View article: Nanoparticle-assisted synthesis of anti-aging secondary metabolites in medicinal plants
Nanoparticle-assisted synthesis of anti-aging secondary metabolites in medicinal plants Open
The application of plant secondary metabolites possessing anti-aging characteristics has garnered significant interest among researchers in this domain, owing to their potential benefits in the pharmaceutical and cosmetic sectors. Numerous…
View article: Variation of the encoding hyaluronic receptors Hyaluronan-mediated motility receptor (rs299295) and Stabilin-2 (rs2271637) genes with prostate neoplasms risk: A case-control and in silico study
Variation of the encoding hyaluronic receptors Hyaluronan-mediated motility receptor (rs299295) and Stabilin-2 (rs2271637) genes with prostate neoplasms risk: A case-control and in silico study Open
Background: Hyaluronan-mediated motility receptor (HMMR) and Stabilin-2 (STAB2), known as extracellular matrix cell surface protein’s receptors, bind to hyaluronic acid and lead to various cell functions. Objective: The study aims to inves…
View article: The role of natural exosomes from SHED-MSC in immunoregulation of M0/M1 polarized macrophage cells
The role of natural exosomes from SHED-MSC in immunoregulation of M0/M1 polarized macrophage cells Open
Introduction Exosomes (EXOs) as a targeted cell-free therapy could offer a new therapeutic strategy for immune-mediated inflammatory diseases, due to their stability and ease of storage and handling. This study focused on exosomes derived …
View article: Applications of Biocompatible Nanoparticles in Plant Biotechnology for Enhanced Secondary Metabolite Biosynthesis
Applications of Biocompatible Nanoparticles in Plant Biotechnology for Enhanced Secondary Metabolite Biosynthesis Open
Nanoparticles within the realm of plant biotechnology, have garnered considerable interest in recent years, as a result of their notable and unique chemical and physical criteria, which can affect the growth, productivity, and biochemical …
View article: Association of PON1-L55M Genetic Variation with Idiopathic Male Infertility in an Iranian Population: A Case-Control Study
Association of PON1-L55M Genetic Variation with Idiopathic Male Infertility in an Iranian Population: A Case-Control Study Open
The risk of male infertility is related to gene polymorphisms that reduce the activity of antioxidant enzymes. Serum paraoxonase 1 (PON1), is an antioxidant calcium-dependent enzyme has been implicated in the pathogenesis of male infertili…
View article: Association between PON1-rs662 Gene Polymorphism and Diabetic Retinopathy in Population of the Qom, Iran
Association between PON1-rs662 Gene Polymorphism and Diabetic Retinopathy in Population of the Qom, Iran Open
Background: Diabetic retinopathy is the most severe diabetic microvascular complication that causes changes in the vessel wall. One of the genes involved in this disease is PON1, which encodes paraoxanase1 protein in liver and kidney. It m…
View article: Optimization of Affinity Chromatography Based on Sepharose 4B- chitin for Rapid Purification of <i>Urtica dioica</i> Agglutinin.
Optimization of Affinity Chromatography Based on Sepharose 4B- chitin for Rapid Purification of <i>Urtica dioica</i> Agglutinin. Open
According to our findings, we suggested that dissolving chitin in the polar solvent of Trichloroacetic acid, using Sepharose 4B as the beads of a matrix, and increasing the column length might lead to a decrease in the half-width of the pe…
View article: Myopic regression after photorefractive keratectomy: a retrospective cohort study
Myopic regression after photorefractive keratectomy: a retrospective cohort study Open
Background: Myopic regression is a major complication of photorefractive keratectomy (PRK). The rates and causes vary considerably among different studies. This study aimed to investigate myopic regression at six months after myopic PRK.
…
View article: Missense polymorphisms potentially involved in mandibular prognathism
Missense polymorphisms potentially involved in mandibular prognathism Open
In this study, we identified PLXNA2-rs4844658, DUSP6-rs2279574, and FBN3-rs33967815 as potential risk factors for mandibular prognathism using several web-based tools. According to the possible roles of PLXNA2, DUSP6, …
View article: Variation of the Genes Encoding Antioxidant Enzymes SOD2 (rs4880), GPX1 (rs1050450) and CAT (rs1001179) and Susceptibility to Male Infertility: A Genetic Association Study and in silico Analysis
Variation of the Genes Encoding Antioxidant Enzymes SOD2 (rs4880), GPX1 (rs1050450) and CAT (rs1001179) and Susceptibility to Male Infertility: A Genetic Association Study and in silico Analysis Open
Enzymatic factors including superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) are among the most important protective antioxidant systems in human semen. This study was conducted to investigate the association be…
View article: Induction of anti-tumor immunity by human telomerase reverse transcriptase (hTERT) and viral-derived peptides in breast cancer mice models
Induction of anti-tumor immunity by human telomerase reverse transcriptase (hTERT) and viral-derived peptides in breast cancer mice models Open
Human telomerase reverse transcriptase (hTERT) is the most common tumor-associated antigen (TAA) and its activity is upregulated in more than 90% of cancers. Therefore, its targeting could be used in cancer immunotherapy. In continuing wit…
View article: Induction of anti-tumor immunity by human telomerase reverse transcriptase (hTERT) and viral-derived peptides in breast cancer mouse models
Induction of anti-tumor immunity by human telomerase reverse transcriptase (hTERT) and viral-derived peptides in breast cancer mouse models Open
Human telomerase reverse transcriptase (hTERT) is the most common tumor-associated antigen (TAA) and its activity is upregulated in more than 90% of cancers. Therefore, its targeting can be used in cancer immunotherapy. In continuing with …
View article: CD44 rs13347C>T Variants in 3'UTR and Prostate Neoplasms: A Case-control Study and Bioinformatics Approach.
CD44 rs13347C>T Variants in 3'UTR and Prostate Neoplasms: A Case-control Study and Bioinformatics Approach. Open
CD44, a cell-surface receptor and a key player in cellular signaling, can act as both tumor suppressor and promoter. This study aimed to investigate the association of CD44 rs13347C>T variants with prostate neoplasms, including both…
View article: Inhibitory Potency of UDA Lectin on Neovascularization: A Biomolecule for Carbohydrate-Mediated Targeting of Angiogenesis
Inhibitory Potency of UDA Lectin on Neovascularization: A Biomolecule for Carbohydrate-Mediated Targeting of Angiogenesis Open
Background Cellular vascularization processes including proliferation, migration, and tube formation are selectively the purpose of current angiogenic inhibitors. In this study, we investigated the impact of Urtica dioica agglutinin (UDA) …
View article: Mutant Allele of CD44 (rs8193C>T) and Pum2 Regulatory Element as A Prognosis Factor of Prostate Neoplasms: A Case-Control and In Silico Studies.
Mutant Allele of CD44 (rs8193C>T) and Pum2 Regulatory Element as A Prognosis Factor of Prostate Neoplasms: A Case-Control and In Silico Studies. Open
Based on this, the presence of the T mutant allele of CD44 (rs8193C>T) in the populations may create a regulatory element-binding site for Pum2. So, it could be known as a prognosis factor and prediction of prostate neoplasms. However, mor…
View article: Effects of <i>Urtica dioica</i> agglutinin on glycotargeting of the vasculature: an <i>in ovo</i> study on chicken embryo.
Effects of <i>Urtica dioica</i> agglutinin on glycotargeting of the vasculature: an <i>in ovo</i> study on chicken embryo. Open
The angiogenesis process is a pivotal cellular process involved in both developmental and pathological circumstances. In this study we investigated effect of Urtica dioica agglutinin (UDA), as an unusual phyto-lectin from the chitin-bindin…
View article: Human DT-diaphorase expression in <i>Escherichia coli</i>: optimization, purification and structural stability.
Human DT-diaphorase expression in <i>Escherichia coli</i>: optimization, purification and structural stability. Open
Expression and purification of human DT-diaphorase, also referred to as NAD(P)H quinone oxidoreductase 1 (NQO1; EC. 1.6.99.2), which is a flavoprotein belongs to the family of oxidoreductases are optimized. The DT-diaphorase plays an impor…
View article: Comparing Bactericidal Effect of Pulsed Flash Lamp and Continuous Sterilization UV Lamps with a Cold Atmospheric Pressure Plasma Jet on E. Coli Solid Growth Medium
Comparing Bactericidal Effect of Pulsed Flash Lamp and Continuous Sterilization UV Lamps with a Cold Atmospheric Pressure Plasma Jet on E. Coli Solid Growth Medium Open
Comparing Bactericidal Effect of Pulsed Flash Lamp and Continuous Sterilization UV Lamps with a Cold Atmospheric Pressure Plasma Jet on E. Coli Solid Growth Medium
View article: Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019 Open
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently the most important etiological agent of acute respiratory distress syndrome (ARDS) with millions of infections and deaths in the last 2 yea…
View article: The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases
The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases Open
Progressive abnormality and loss of axons and neurons in the central nervous system (CNS) cause neurodegenerative diseases (NDs). Protein misfolding and its collection are the most important pathological features of NDs. Astrocytes are the…
View article: In vivo Assessment of APPJ Discharge on the Earthworm: Coelomic TAC and MDA Levels, Cell Death and Tissue Regeneration
In vivo Assessment of APPJ Discharge on the Earthworm: Coelomic TAC and MDA Levels, Cell Death and Tissue Regeneration Open
The cold atmospheric pressure plasma jet (APPJ) is one of the effective tools with medical applications that its positive effects have been reported by various researchers, including sterilization of liquid and solid surfaces, treatment of…
View article: Scientific Evidences of the "Prostration Effect" on the Forehead of Some Prayer
Scientific Evidences of the "Prostration Effect" on the Forehead of Some Prayer Open
Prostration, putting forehead on the ground or clay-tablet, has many medical benefits. But some reports showed on the forehead of a few prayers it causes prostration effect/PE or clay-tablet effect/CTE, as a skin-callosity, on his/her fore…
View article: Comparative in silico Survey of Retinoic Acids as Putative Biomolecules Against VEGF Receptors: A Glycomics-based Approach
Comparative in silico Survey of Retinoic Acids as Putative Biomolecules Against VEGF Receptors: A Glycomics-based Approach Open
In this study, putative interactions between all of the retinoic acid (RA) ligands (all-trans (At), 9-cis (9c), and 13-cis (13c)), and VEGF receptors (VEGFR-1, -2 and -3) were investigated. It was performed considering the glycosylation st…
View article: Methylation Status of <i>MTHFR</i> Promoter and Oligozoospermia Risk: An Epigenetic Study and in Silico Analysis.
Methylation Status of <i>MTHFR</i> Promoter and Oligozoospermia Risk: An Epigenetic Study and in Silico Analysis. Open
Based on our findings, methylation of the MTHFR gene promoter region may be a risk factor for oligozoospermia. However, this is a preliminary report representing data for future comprehensive studies to make a clinical conclusion on…
View article: PTGS2 Over-expression: A Colorectal Carcinoma Initiator Not an Invasive Factor
PTGS2 Over-expression: A Colorectal Carcinoma Initiator Not an Invasive Factor Open
The increase in PTGS2 is related to the occurrence of CRC among patient samples. But in both part of this study, PTGS2 is not an invasive factor, and it does not affect the cell differentiation of tumors and metastasis. Based…
View article: Genetic diversity and structure of the Great Gerbil,<i>Rhombomys opimus</i>, in Iran (Mammalia: Rodentia)
Genetic diversity and structure of the Great Gerbil,<i>Rhombomys opimus</i>, in Iran (Mammalia: Rodentia) Open
The Great Gerbil, Rhombomys opimus, is widely distributed in degraded and fragmented desert and semi-desert habitats of the Iranian Plateau. Recent habitat fragmentation from overgrazing by livestock and a government-sponsored roden…
View article: The LEPR (853A>G and 511A>G) Transitions may Enhance Idiopathic Recurrent Miscarriage: Evidences Based on Case-control and in silico Studies
The LEPR (853A>G and 511A>G) Transitions may Enhance Idiopathic Recurrent Miscarriage: Evidences Based on Case-control and in silico Studies Open
Previous studies in human leptin receptor protein (LEPR) signaling are important in the establishment of fetal growth. Idiopathic recurrent miscarriage (IRM) may be the result of abnormal placental and fetal development. Thus single nucleo…
View article: Induction of AHR Gene Expression in Colorectal Cancer Cell Lines by Cucurbitacin D, E, and I
Induction of AHR Gene Expression in Colorectal Cancer Cell Lines by Cucurbitacin D, E, and I Open
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and its induction may result in suppressing of cell proliferation in colorectal cancer (CRC). Cucurbitacin D (CucD), E (CucE) and I (CucI) are plant derived metabol…
View article: Human AGT -p.Met268Thr and coronary heart disease risk: a case-control study and meta-analysis
Human AGT -p.Met268Thr and coronary heart disease risk: a case-control study and meta-analysis Open
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Mohammadi H, Razavi N, Abbasi A, Babaei F, Seyedrezazadeh E, Hosseinzadeh A. Human AGT-p.Met268Thr and coronary heart disease risk: a case-control study and …