Abba C. Zubair
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View article: EGFR mRNA-Engineered Mesenchymal Stem Cells (MSCs) Demonstrate Radioresistance to Moderate Dose of Simulated Cosmic Radiation
EGFR mRNA-Engineered Mesenchymal Stem Cells (MSCs) Demonstrate Radioresistance to Moderate Dose of Simulated Cosmic Radiation Open
Galactic cosmic ray (GCR) radiation is a major barrier to human space exploration beyond Earth’s magnetic field protection. Mesenchymal stem cells (MSCs) are found in all organs and play a critical role in repair and regeneration of tissue…
View article: Intra-articular delivery of allogeneic bone marrow derived mesenchymal stromal cells (BM-MSCs) for painful lumbar facet arthropathy: a phase I clinical trial
Intra-articular delivery of allogeneic bone marrow derived mesenchymal stromal cells (BM-MSCs) for painful lumbar facet arthropathy: a phase I clinical trial Open
View article: Azole resistance using agar screening in environmental isolates of Aspergillus species from Pakistan
Azole resistance using agar screening in environmental isolates of Aspergillus species from Pakistan Open
Background: Azole resistance in clinical and environmental Aspergillus isolates has been reported globally. The environmental route of resistance follows the use of fungicides in agricultural practices and is known to be more common than t…
View article: EGFR mRNA-Engineered Mesenchymal Stem Cells (MSCs) Demonstrate Radioresistance to Moderate Dose of Simulated Cosmic Radiation
EGFR mRNA-Engineered Mesenchymal Stem Cells (MSCs) Demonstrate Radioresistance to Moderate Dose of Simulated Cosmic Radiation Open
Galactic cosmic ray (GCR) radiation is a major barrier to human space exploration beyond Earth’s magnetic field protection. Mesenchymal stem cells (MSCs) are found in all organs, and they play a critical role in repair and regeneration of …
View article: Frequency of prostate cancer in patients with abnormal prostate-specific antigen (4–10 ng/mL) and normal digital rectal examination of prostate
Frequency of prostate cancer in patients with abnormal prostate-specific antigen (4–10 ng/mL) and normal digital rectal examination of prostate Open
Objective: To determine the frequency of prostate cancer (PCa) in patients with normal digital rectal examination (DRE) and prostate-specific antigen (PSA) levels of 4–10 ng/mL. Material and Methods: This cross-sectional study was conducte…
View article: Safety and Preliminary Efficacy of Allogeneic Adipose-Derived Mesenchymal Stem Cells in Reducing Arteriovenous Fistula Failure: A Phase 1 Clinical Trial
Safety and Preliminary Efficacy of Allogeneic Adipose-Derived Mesenchymal Stem Cells in Reducing Arteriovenous Fistula Failure: A Phase 1 Clinical Trial Open
View article: Generation of Current Good Manufacturing Practices-Grade Mesenchymal Stromal Cell-Derived Extracellular Vesicles Using Automated Bioreactors
Generation of Current Good Manufacturing Practices-Grade Mesenchymal Stromal Cell-Derived Extracellular Vesicles Using Automated Bioreactors Open
Interest in Current Good Manufacturing Practices (cGMP)-grade extracellular vesicles (EVs) is expanding. Some obstacles in this new but rapidly growing field include a lack of standardization and scalability. This review focuses on automat…
View article: Impact of spaceflight on gene expression in cultured human mesenchymal stem/stromal cells
Impact of spaceflight on gene expression in cultured human mesenchymal stem/stromal cells Open
With technological advancements, human’s desire to explore space is growing and more people are staying longer at the international space station (ISS). The impact of microgravity on stem cells (SC) is not fully understood. We explored the…
View article: DETERMINING THE OUTCOME OF REDUCED FUNCTIONING KIDNEY AFTER PERCUTANEOUS NEPHROSTOMY
DETERMINING THE OUTCOME OF REDUCED FUNCTIONING KIDNEY AFTER PERCUTANEOUS NEPHROSTOMY Open
Background: Significant impairment of renal function can result from unilateral urinary tract blockage, especially if the split renal function falls below 20%. Renal function may be preserved with early intervention using percutaneous neph…
View article: Trends in antimicrobial susceptibility pattern of infectious agents isolated during febrile neutropenia (FN) events of acute lymphoblastic leukemia (AL) patients from pakistan
Trends in antimicrobial susceptibility pattern of infectious agents isolated during febrile neutropenia (FN) events of acute lymphoblastic leukemia (AL) patients from pakistan Open
AIM: To evaluate trends in antimicrobial susceptibility patterns of infectious agents isolated in Febrile neutropenia patients of Acute Lymphoblastic Leukemia. BACKGROUND: FN is the most feared complication amongst hematopoietic cancer pat…
View article: Effects of blood donor characteristics and storage on red blood cell haemoglobin β S‐nitrosylation
Effects of blood donor characteristics and storage on red blood cell haemoglobin β S‐nitrosylation Open
Background and Objectives In the setting of tissue hypoxia, S‐nitrosylated haemoglobin (SNO‐Hb) plays crucial roles in the control of blood flow. This is associated with decreased oxygen affinity to haemoglobin and increase in tissue oxyge…
View article: CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow–derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathy
CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow–derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathy Open
Background: Lumbar facet joint arthropathy (LFJA) is a major cause of low back pain (LBP), with current treatments offering limited long-term benefits. Bone marrow–derived mesenchymal stem cells (BM-MSCs) show promise due to their immunomo…
View article: Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth
Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth Open
View article: Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage
Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage Open
View article: Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer
Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer Open
Most thyroid cancer deaths are attributed to a subset of poorly differentiated, metastatic tumors. To improve treatment options for aggressive thyroid cancers, we developed a novel thyroid-stimulating hormone receptor (TSHR)-targeted chime…
View article: Understanding the Importance and Future Directions of Cultural Sensitivity in Healthcare: Developing a Culturally sensitive Patient Experience Framework with Emirati Patients as a Case Study
Understanding the Importance and Future Directions of Cultural Sensitivity in Healthcare: Developing a Culturally sensitive Patient Experience Framework with Emirati Patients as a Case Study Open
In healthcare, patient feedback is pivotal for enhancing care quality, satisfaction, and trust. Cultural factors, as evidenced in previous studies on Emirati patients, significantly shape these perceptions. This paper underscores the unive…
View article: Mesenchymal Stem Cell Therapy in Acute Intracerebral Hemorrhage: A Dose-Escalation Safety and Tolerability Trial
Mesenchymal Stem Cell Therapy in Acute Intracerebral Hemorrhage: A Dose-Escalation Safety and Tolerability Trial Open
Background We conducted a preliminary phase I, dose-escalating, safety, and tolerability trial in the population of patients with acute intracerebral hemorrhage (ICH) by using human allogeneic bone marrow–derived mesenchymal stem/stromal c…
View article: Mesenchymal Stromal Cell Healing Outcomes in Clinical and Pre-Clinical Models to Treat Pressure Ulcers: A Systematic Review
Mesenchymal Stromal Cell Healing Outcomes in Clinical and Pre-Clinical Models to Treat Pressure Ulcers: A Systematic Review Open
Background: Despite numerous measures used to prevent pressure ulcers, their growing prevalence in recent years is expected to continue as the population ages. This review aims to report the outcomes of the regenerative potential of MSCs i…
View article: Phase 1, Dose Escalation, Nonrandomized, Open-Label, Clinical Trial Evaluating the Safety and Preliminary Efficacy of Allogenic Adipose-Derived Mesenchymal Stem Cells for Recurrent Glioblastoma: A Clinical Trial Protocol
Phase 1, Dose Escalation, Nonrandomized, Open-Label, Clinical Trial Evaluating the Safety and Preliminary Efficacy of Allogenic Adipose-Derived Mesenchymal Stem Cells for Recurrent Glioblastoma: A Clinical Trial Protocol Open
BACKGROUND AND OBJECTIVES: Despite standard of care with maximal safe resection and chemoradiation, glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. Surgical resection provides a window of opportunity to l…
View article: 154 A Scoping Review of the Management of Benign Prostate Hyperplasia in Africa
154 A Scoping Review of the Management of Benign Prostate Hyperplasia in Africa Open
Aim Benign prostatic hyperplasia (BPH) is a non-malignant prostate gland enlargement of unknown cause that affects more than 50% of men over 60 and is the most common cause of bladder outlet obstruction and voiding symptoms. BPH is treated…
View article: Trends in utilization of stored cryopreserved autologous peripheral hematopoietic cells intended for a second (or beyond) autologous hematopoietic cell transplantation in patients with multiple myeloma: a single center experience
Trends in utilization of stored cryopreserved autologous peripheral hematopoietic cells intended for a second (or beyond) autologous hematopoietic cell transplantation in patients with multiple myeloma: a single center experience Open
Due to the advent of effective novel therapies for multiple myeloma (MM), the use of cryopreserved autologous peripheral blood hematopoietic cells (APBHC) for a salvage autologous transplant (auto-HCT) is in decline. We evaluated utilizati…
View article: Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review
Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review Open
Background: The use of bone morphogenic protein and mesenchymal stem cells has shown promise in promoting bone regeneration in calvarial defects. However, a systematic review of the available literature is needed to evaluate the efficacy o…
View article: Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells
Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells Open
View article: In Vitro Enhanced Osteogenic Potential of Human Mesenchymal Stem Cells Seeded in a Poly (Lactic-<i>co</i>-Glycolic) Acid Scaffold: A Systematic Review
In Vitro Enhanced Osteogenic Potential of Human Mesenchymal Stem Cells Seeded in a Poly (Lactic-<i>co</i>-Glycolic) Acid Scaffold: A Systematic Review Open
Study Design Human bone marrow stem cells (hBMSCs) and human adipose-derived stem cells (hADSCs) have demonstrated the capability to regenerate bone once they have differentiated into osteoblasts. Objective This systematic review aimed to …
View article: 324 Sensitizing poorly differentiated thyroid cancers to TSHR-CART cell therapy with MEK inhibitors
324 Sensitizing poorly differentiated thyroid cancers to TSHR-CART cell therapy with MEK inhibitors Open
Background Thyroid cancer incidence is rising,1 and most thyroid cancer deaths are attributed to a subset of de-differentiated, treatment-refractory, metastatic tumors. Thyroid stimulating hormone receptor (TSHR),2,3 …
View article: Feasibility and Safety of Low-Dose Mesenchymal Stem Cell Infusion in Lung Transplant Recipients
Feasibility and Safety of Low-Dose Mesenchymal Stem Cell Infusion in Lung Transplant Recipients Open
Background We have previously shown bone marrow-derived mesenchymal stem cells (MSCs) may shift immune responses toward anti-inflammatory pathways and stabilize the course of obstructive chronic lung allograft syndrome (o-CLAD) after lung …
View article: 116. Hypoxic Culturing of Human Adipose-derived Stem Cells Enhances Cellular Proliferation and Angiogenesis
116. Hypoxic Culturing of Human Adipose-derived Stem Cells Enhances Cellular Proliferation and Angiogenesis Open
Purpose: Human adipose-derived stem cells (hADSCs) have received attention lately, because of their ease of harvesting and ability to be substantially multiplied in laboratory cultures. Stem cells are usually cultured under atmospheric con…
View article: 35. Human Adipose-derived Stem Cells Decrease Skin Damage in Mice After Scalp Irradiation: A Pilot Experiment
35. Human Adipose-derived Stem Cells Decrease Skin Damage in Mice After Scalp Irradiation: A Pilot Experiment Open
Purpose: The treatment for radiation dermatitis ulcers is surgical reconstruction. We aimed to characterize the effects of human adipose-derived stem cells (hAdMSCs) to prevent complications of radiation dermatitis of the scalp in an immun…
View article: Table of Contents
Table of Contents Open
View article: Impact of AMATEA™ on physiological measures and gaming performance in active gamers: a placebo controlled, double-blind, randomized study
Impact of AMATEA™ on physiological measures and gaming performance in active gamers: a placebo controlled, double-blind, randomized study Open
Although regenerative therapy is a promising field of study and treatment in medicine, much is still unknown. The potential for angiogenic therapeutics with stem cells is high, but more so, if we discover ways to enhance their natural angi…