Abbas F. Almulla
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View article: Increased Insulin Resistance and Hyperglycemia in Long COVID disease: A Systematic Review and Meta-Analysis
Increased Insulin Resistance and Hyperglycemia in Long COVID disease: A Systematic Review and Meta-Analysis Open
Background: accumulating evidence suggests that Long COVID (LC) is mediated by chronic immune activation, oxidative stress, and metabolic dysregulation. These processes may impair glucose homeostasis and promote insulin resistance (IR). Ho…
View article: Lower insulin resistance in Chinese patients with severe major depressive disorder: associations with the inflammatory response
Lower insulin resistance in Chinese patients with severe major depressive disorder: associations with the inflammatory response Open
Background Major depressive disorder (MDD) is widely acknowledged as stemming from the dysregulation of neuroimmune, metabolic, and oxidative stress (NIMETOX) pathways. The objective of this study was to examine insulin metabolism in Chine…
View article: The acute phase inflammatory response as a key determinant of reduced lipid-associated antioxidant defenses in Chinese patients with major depressive disorder
The acute phase inflammatory response as a key determinant of reduced lipid-associated antioxidant defenses in Chinese patients with major depressive disorder Open
Background Major depressive disorder (MDD) is characterized by interacting neuro-immune, metabolic, and oxidative stress pathways. Here we examine the interactions between the acute phase (AP) response and serum lipids in Chinese MDD patie…
View article: Monomeric CRP and Negative Acute Phase Proteins but not pentameric CRP are biomarkers of major depression and especially major dysmood disorder
Monomeric CRP and Negative Acute Phase Proteins but not pentameric CRP are biomarkers of major depression and especially major dysmood disorder Open
Background Contrary to the negative acute-phase protein (APP) response, there is no consistent correlation between serum pentameric C-reactive protein (pCRP) and major depression (MDD). Monomeric CRP (mCRP), a dissociation product of pCRP …
View article: C-reactive protein is not a biomarker of depression severity in drug-naïve obese patients with metabolic syndrome
C-reactive protein is not a biomarker of depression severity in drug-naïve obese patients with metabolic syndrome Open
Background: Metabolic syndrome (MetS) is highly prevalent among adults and is frequently accompanied by depressive symptoms. While high-sensitivity C-reactive protein (hsCRP) has been proposed as a potential indicator of depression, existi…
View article: The negative acute phase response and not serum C-reactive protein is a major biomarker of major depression: a precision nomothetic psychiatry study
The negative acute phase response and not serum C-reactive protein is a major biomarker of major depression: a precision nomothetic psychiatry study Open
Background Recently, it was suggested that serum high-sensitive C-reactive protein (hsCRP) serves as a biomarker for “inflammatory major depression (MDD)” when serum hsCRP exceeds > 3.0 mg/L. Since 1991-1992, it has been known that MDD is …
View article: Alterations in Neuroimmune, Metabolic, and Oxidative (NIMETOX) Pathways in Post-Stroke Patients: Diagnostic and Prognostic Implications
Alterations in Neuroimmune, Metabolic, and Oxidative (NIMETOX) Pathways in Post-Stroke Patients: Diagnostic and Prognostic Implications Open
Background Stroke remains a primary contributor to disability and mortality globally. Survivors often experience persistent problems associated with neuro-immune, metabolic, and oxidative stress (NIMETOX) pathways. Nevertheless, the combin…
View article: C-reactive protein is not a biomarker of depression severity in drug-naïve obese patients with metabolic syndrome
C-reactive protein is not a biomarker of depression severity in drug-naïve obese patients with metabolic syndrome Open
Background Metabolic syndrome (MetS) is highly prevalent among adults and is frequently accompanied by depressive symptoms. While high-sensitivity C-reactive protein (hsCRP) has been proposed as a potential indicator of depression, existin…
View article: HHV-6 and EBV reactivation in relapsing remitting multiple sclerosis: Disability, progression, and inflammation links
HHV-6 and EBV reactivation in relapsing remitting multiple sclerosis: Disability, progression, and inflammation links Open
View article: Autoantibodies targeting the enteric nerve and non-myelin epitopes in relapsing-remitting multiple sclerosis: diagnostic relevance and viral mimicry
Autoantibodies targeting the enteric nerve and non-myelin epitopes in relapsing-remitting multiple sclerosis: diagnostic relevance and viral mimicry Open
Background Relapsing-remitting multiple sclerosis (RRMS) involves autoimmune responses against central nervous system (CNS) self-epitopes, potentially triggered by Epstein–Barr virus (EBV) and Human Herpesvirus 6 (HHV-6) reactivation. Obje…
View article: Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study.
Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study. Open
View article: Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism
Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism Open
View article: Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study
Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study Open
Background The Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) are frequently linked to neuropsychiatric illnesses such as multiple sclerosis, depression, and chronic fatigue syndrome/myalgic encephalomyelitis. These viruses may i…
View article: Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks
Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks Open
Background Major depressive disorder (MDD) is associated with neuro-immune – metabolic – oxidative (NIMETOX) pathways. Aims To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) with and without metabolic syndrome (Met…
View article: Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation
Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation Open
Autoimmune reactivities targeting myelin-related proteins are valuable biomarkers of RRMS and the severity and progression of RRMS. Reactivation of EBV and HHV-6 may trigger or maintain these autoimmune responses thereby impacting disease …
View article: Elevated Atherogenicity in Long COVID: A Systematic Review and Meta-Analysis
Elevated Atherogenicity in Long COVID: A Systematic Review and Meta-Analysis Open
View article: The physio-affective symptoms of Long COVID are strongly predicted by the severity of the acute infectious phase, and lowered antioxidants, nitric oxide, and alanine transaminase levels
The physio-affective symptoms of Long COVID are strongly predicted by the severity of the acute infectious phase, and lowered antioxidants, nitric oxide, and alanine transaminase levels Open
View article: Biological Abnormalities in Long COVID Disease: A mini review
Biological Abnormalities in Long COVID Disease: A mini review Open
View article: Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression?
Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression? Open
Background Major depressive disorder (MDD) and its most severe phenotype, major dysmood disorder (MDMD), are distinguished by the activation of the immune-inflammatory response system, T cell activation, and a relative T regulatory cell su…
View article: Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: associations with human herpesvirus-6 and Epstein-Barr Virus reactivation
Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: associations with human herpesvirus-6 and Epstein-Barr Virus reactivation Open
Background The pathogenesis of relapsing-remitting multiple sclerosis (RRMS) is linked to autoimmune attacks against myelin proteins, and reactivation of Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6). However, the connection bet…
View article: Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms Open
Brain-targeted autoimmunity contributes significantly to the pathogenesis of Long COVID and the severity of its physio-affective phenome.
View article: Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression?
Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression? Open
Background Major depressive disorder (MDD) and its most severe phenotype, major dysmood disorder (MDMD), are distinguished by the activation of the immune-inflammatory response system, T cell activation, and a relative T regulatory cell su…
View article: Chronic fatigue syndrome, depression, and anxiety symptoms due to relapsing-remitting multiple sclerosis are associated with reactivation of Epstein-Barr virus and Human Herpesvirus 6
Chronic fatigue syndrome, depression, and anxiety symptoms due to relapsing-remitting multiple sclerosis are associated with reactivation of Epstein-Barr virus and Human Herpesvirus 6 Open
Relapsing-remitting multiple sclerosis (RRMS) is defined by elevated IgG/IgA/IgM responses targeting Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA) and deoxyuridine-triphosphatases (dUTPases) of Human herpsesvirus-6 (HHV-6) and EBV. The…
View article: From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID.
From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID. Open
Background: Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, and its affective and chronic fatigue syndrome (CFS) symptoms, labeled "the physio-affective phenome." Objectives: To investigate whether Lo…
View article: From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID
From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID Open
Background Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, and its affective and chronic fatigue syndrome (CFS) symptoms, labeled “the physio-affective phenome.” Objectives To investigate whether Long…
View article: Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms Open
Background Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objectives To examine whether Long COVID, and its accompanying affective s…
View article: Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are all associated with neurotoxic immune networks and their intricate interactions with metabolic syndrome.
Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are all associated with neurotoxic immune networks and their intricate interactions with metabolic syndrome. Open
Background Major depressive disorder (MDD) is considered to be a neuroimmune disorder. However, there are no data regarding the association between comprehensive immune profiles and their interactions with the metabolic syndrome (MetS) in …
View article: Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome
Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome Open
Background: Persistent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reactivation of dormant viruses, and immune-oxidative responses are involved in long COVID. Objectives: To investigate whether long COVID a…
View article: In major dysmood disorder, physiosomatic, chronic fatigue and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity
In major dysmood disorder, physiosomatic, chronic fatigue and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity Open
Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood disorder (MDMD), is associated w…
View article: Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors largely predict the phenome of first-episode mild depression in undergraduate students
Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors largely predict the phenome of first-episode mild depression in undergraduate students Open
Undergraduate students are frequently afflicted by major depressive disorder (MDD). Oxidative and nitrosative stress (O&NS) has been implicated in the pathophysiology of MDD. There is no information regarding whether mild outpatient MDD (S…