Abbas Pardakhty
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View article: Preparation, Pharmaceutical Characterization, <i>In-Vitro</i> Release Kinetics, and Antifungal Efficacy Investigation of Fluconazole Niosomal Hydrogel
Preparation, Pharmaceutical Characterization, <i>In-Vitro</i> Release Kinetics, and Antifungal Efficacy Investigation of Fluconazole Niosomal Hydrogel Open
Background: Lipid vesicular systems can enhance the penetration of antifungal drugs like fluconazole in topical applications. Niosomes, composed of non-ionic surfactants and cholesterol, are a key type of lipid vesicles. Methods: Fluconazo…
View article: Amino acid-assisted green synthesis of a porous binary oxide nanocomposite for sensitive electrochemical detection of chlorpromazine
Amino acid-assisted green synthesis of a porous binary oxide nanocomposite for sensitive electrochemical detection of chlorpromazine Open
In this work, an eco-friendly method was used to synthesize cerium–bismuth oxide nanostructures as a binary oxide nanocomposite. For this purpose, L -alanine was utilized as a novel and green fuel to produce a nanostructured Bi 2 O 3 –CeO …
View article: Formulation and physicochemical characteristics of niosomes containing standardized hydroalcoholic extracts of eucalyptus (Eucalyptus galbie) and green tea (Camellia sinensis L.) with potential anti-acne effect
Formulation and physicochemical characteristics of niosomes containing standardized hydroalcoholic extracts of eucalyptus (Eucalyptus galbie) and green tea (Camellia sinensis L.) with potential anti-acne effect Open
Background: Acne vulgaris, a chronic inflammatory condition of sebaceous glands, is often linked to microbial colonization (e.g., Cutibacterium acnes , Staphylococcus epidermidis, Staphylococcus aureus ) and inflammatory factors. This stud…
View article: Development and Characterization of Calcium Ion‐Enhanced Nanophytosomes Encapsulating Pomegranate Fruit Extract
Development and Characterization of Calcium Ion‐Enhanced Nanophytosomes Encapsulating Pomegranate Fruit Extract Open
Nanophytosomes (NP S ) loaded with whole pomegranate fruit extract with peel and arils (PFE) at different levels of phosphatidylcholine (PC) were produced using a thin‐film hydration method and reinforced with calcium ions. PFE was obtaine…
View article: A Novel Niosomal Doxycycline/Triamcinolone Medicament Matches Calcium Hydroxide for Low Tooth Staining: A 4-Week <i>in Vitro</i> Study.
A Novel Niosomal Doxycycline/Triamcinolone Medicament Matches Calcium Hydroxide for Low Tooth Staining: A 4-Week <i>in Vitro</i> Study. Open
Emphasize that at 4 weeks, all medicaments induced clinically acceptable ∆E, with niosomal performing similarly to calcium hydroxide alone and significantly better than the conventional doxycycline+triamcinolone combination.
View article: Preparation, characterization, and leishmanicidal assessment of silver- and dapsone-loaded niosomes co-administration: in silico and in vitro study
Preparation, characterization, and leishmanicidal assessment of silver- and dapsone-loaded niosomes co-administration: in silico and in vitro study Open
Purpose: Currently, there is a crucial need for alternative strategies to control leishmaniasis, which threatens more than 1 billion people worldwide. The simultaneous use of combination therapy and nanostructured lipid carriers aimed to a…
View article: Niosome as a drug delivery carrier for Sorafenib: Preparation, investigation of physicochemical properties, and in vitro effects on HepG2 cell line
Niosome as a drug delivery carrier for Sorafenib: Preparation, investigation of physicochemical properties, and in vitro effects on HepG2 cell line Open
Purpose: Sorafenib is known as one of the oral anti-cancer drugs used in liver cancer. However, its lipophilic nature can lead to side effects, variable pharmacokinetics, and poor absorption. The use of novel drug delivery systems, such as…
View article: Assessing effectiveness of adding niosomal atorvastatin 1% ointment to topical calcineurin inhibitor treatment in non‐segmental vitiligo
Assessing effectiveness of adding niosomal atorvastatin 1% ointment to topical calcineurin inhibitor treatment in non‐segmental vitiligo Open
Background Treatment of vitiligo is still a big challenge for dermatologists. The efficacy of statins in the treatment of vitiligo is controversial. Aim and Objective We studied possible therapeutic effect of topical 1% niosomal atorvastat…
View article: Short-term Safety of Covaxin, Sinopharm, Sputnik V, and AstraZeneca COVID-19 Vaccines Among Iranian Healthcare Workers: A Cross-Sectional Study
Short-term Safety of Covaxin, Sinopharm, Sputnik V, and AstraZeneca COVID-19 Vaccines Among Iranian Healthcare Workers: A Cross-Sectional Study Open
Background: Several coronavirus disease 2019 (COVID-19) vaccines, utilizing different platforms, have successfully obtained emergency clinical use authorization to prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infect…
View article: Comparative Evaluation of Native and Liposomal Curcumin Against Acute Reproductive Toxicity Induced by Cadmium Chloride in Male Mice
Comparative Evaluation of Native and Liposomal Curcumin Against Acute Reproductive Toxicity Induced by Cadmium Chloride in Male Mice Open
Exposure to cadmium chloride (Cd) is linked to reproductive disorders. Curcumin (CUR), a traditional medicinal compound, has been considered for its therapeutic properties. The present study evaluated the antioxidant effects of CUR and lip…
View article: Niosomal Doxycycline and Triamcinolone: A Novel Approach to Minimize Cytotoxicity in Endodontic Medicaments.
Niosomal Doxycycline and Triamcinolone: A Novel Approach to Minimize Cytotoxicity in Endodontic Medicaments. Open
This study suggests that encapsulating doxycycline in niosomal structures (D2) reduces cytotoxicity in murine fibroblast cell lines (L929) for at least 24 and 48 hours. These findings offer promising implications for the development of end…
View article: The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses Open
Background The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. This study aimed to determine the prevalence…
View article: Comparative Efficacy of Analgesics for Pain Relief in Patients with Symptomatic Irreversible Pulpitis Prior to Emergency Endodontic Treatment: A Randomized Controlled Trial.
Comparative Efficacy of Analgesics for Pain Relief in Patients with Symptomatic Irreversible Pulpitis Prior to Emergency Endodontic Treatment: A Randomized Controlled Trial. Open
Both ibuprofen and Novafen can serve as the analgesics of choice for pain relief in patients with symptomatic irreversible pulpitis with moderate to severe pain when emergency endodontic treatment cannot be immediately performed.
View article: Empagliflozin induces apoptotic-signaling pathway in embryonic vasculature: In vivo and in silico approaches via chick’s yolk sac membrane model
Empagliflozin induces apoptotic-signaling pathway in embryonic vasculature: In vivo and in silico approaches via chick’s yolk sac membrane model Open
The present investigation was conducted to evaluate the vascular-toxicity of empagliflozin (EMP) in embryonic vasculature. Firstly, the vascular-toxicity of the drug as well as its interaction with apoptotic regulator proteins was predicte…
View article: Preparation and evaluation of physicochemical properties and anti-leishmanial activity of zirconium/tioxolone niosomes against Leishmania major
Preparation and evaluation of physicochemical properties and anti-leishmanial activity of zirconium/tioxolone niosomes against Leishmania major Open
Due to the limitations of current chemotherapy for the treatment of leishmaniasis, there is an urgent requirement to search for new anti-leishmanial compounds and nano-drug delivery systems including niosomes. Therefore, the aim of this st…
View article: The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses Open
Background: The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. The aim of this study was to determine the …
View article: Physicochemical Evaluation and Formulation of Propranolol Niosomal Gel with a Potential Effect on Infantile Hemangioma
Physicochemical Evaluation and Formulation of Propranolol Niosomal Gel with a Potential Effect on Infantile Hemangioma Open
Introduction: Propranolol is a non-specific beta-blocker that is used to treat hypertension, angina, arrhythmia, tremor, and manage thyrotoxicosis. Based on the results of various studies, propranolol can control infantile hemangioma by va…
View article: Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems
Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems Open
Dexamethasone (DEX) has been widely used to treat a variety of diseases, including autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19. However, DEX usage is often restricted in the clinic due to its poor…
View article: Therapeutic effects of the as-synthesized polylactic acid/chitosan nanofibers decorated with amphotricin B for in vitro treatment of Leishmaniasis
Therapeutic effects of the as-synthesized polylactic acid/chitosan nanofibers decorated with amphotricin B for in vitro treatment of Leishmaniasis Open
Leishmaniasis is one of the biggest concerns of the World Health Organization (WHO) due to its severe side effects, the emergence of resistance, and secondary bacterial infections; therefore, it was reported as an epidemic, especially in i…
View article: Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature
Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature Open
Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considere…
View article: Preparation of pH-Responsive Vesicular Deferasirox: Evidence from <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Evaluations
Preparation of pH-Responsive Vesicular Deferasirox: Evidence from <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Evaluations Open
pH-sensitive nanocarriers can effectively deliver anticancer drugs to tumors and reduce the adverse effects of conventional chemotherapy. In this light, we prepared a novel pH-responsive deferasirox (DFX)-loaded vesicle and comprehensively…
View article: Successful Application of Alpha Lipoic Acid Niosomal Formulation in Cerebral Ischemic Reperfusion Injury in Rat Model
Successful Application of Alpha Lipoic Acid Niosomal Formulation in Cerebral Ischemic Reperfusion Injury in Rat Model Open
Purpose: Free radicals such as hydroxyl and peroxide are contributing factors to neuronaldestruction in cerebral ischemia. Alpha-lipoic acid (ALA) is one of the potent knownantioxidants. Preparation of ALA niosomes allows IV injection and …
View article: Therapeutic Effects of The As-Synthesized Polylactic Acid/Chitosan Nanofibers Decorated With Amphotricin B For In Vitro Treatment of Leishmaniasis
Therapeutic Effects of The As-Synthesized Polylactic Acid/Chitosan Nanofibers Decorated With Amphotricin B For In Vitro Treatment of Leishmaniasis Open
Leishmaniasis as a third most important vector-borne disease caused by different species of a Leishmania flagellum protozoan. Leishmaniasis as a one of the biggest concerns of the World Health Organization due to the severe side effects, t…