Alyaa Dawoud
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View article: Translational molecular imaging and drug development in multiple sclerosis
Translational molecular imaging and drug development in multiple sclerosis Open
View article: Efficacy and safety of fecal microbiota transplantation in the management of parkinson’s disease: a systematic review
Efficacy and safety of fecal microbiota transplantation in the management of parkinson’s disease: a systematic review Open
View article: A first-in-class EGFR-directed KRAS G12V selective inhibitor
A first-in-class EGFR-directed KRAS G12V selective inhibitor Open
Despite KRASG12V being the second most common KRAS mutation in cancer, no direct inhibitors targeting KRASG12V have been approved. RNA interference (RNAi) has faced numerous obstacles as cancer therapeutic, including …
View article: Tumor suppressors in Sox2-mediated lung cancers promote distinct cell-intrinsic and immunologic remodeling
Tumor suppressors in Sox2-mediated lung cancers promote distinct cell-intrinsic and immunologic remodeling Open
Non-small cell lung cancer (NSCLC) largely consists of lung squamous carcinoma (LUSC) and lung adenocarcinoma (LUAD). Alterations in the tumor protein p53 (TP53) and phosphatase and tensin homolog (PTEN) tumor suppressors are common in bot…
View article: E-11 | Impact of Chronic Kidney Disease and Dialysis Dependence on Transcatheter Aortic Valve Replacement Outcomes: Insights from a Nationwide Analysis
E-11 | Impact of Chronic Kidney Disease and Dialysis Dependence on Transcatheter Aortic Valve Replacement Outcomes: Insights from a Nationwide Analysis Open
View article: 108P Biomarkers and personalized cancer therapy: A study of trial discontinuation and unpublished rates
108P Biomarkers and personalized cancer therapy: A study of trial discontinuation and unpublished rates Open
View article: Efficacy of vitamin D supplementation on the incidence of preeclampsia: a systematic review and meta-analysis
Efficacy of vitamin D supplementation on the incidence of preeclampsia: a systematic review and meta-analysis Open
Vitamin D supplementation during pregnancy significantly reduces the risk of preeclampsia and preterm labor, though its impact on neonatal outcomes remains unclear. These findings underscore the potential value of vitamin D supplementation…
View article: Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer
Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer Open
Gasotransmitters play crucial roles in regulating many physiological processes, including cell signaling, cellular proliferation, angiogenesis, mitochondrial function, antioxidant production, nervous system functions and immune responses. …
View article: Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer
Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer Open
Gasotransmitters play crucial roles in regulating many physiological processes, including cell signaling, cellular proliferation, angiogenesis, mitochondrial function, antioxidant production, nervous system functions and immune responses. …
View article: Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer
Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer Open
Background Hydrogen sulfide (H 2 S) is a significant endogenous mediator that has been implicated in the progression of various forms of cancer including breast cancer (BC). Cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and …
View article: Involvement of CircRNAs in regulating The “New Generation of Cancer Hallmarks”: A Special Depiction on Hepatocellular Carcinoma
Involvement of CircRNAs in regulating The “New Generation of Cancer Hallmarks”: A Special Depiction on Hepatocellular Carcinoma Open
The concept of 'Hallmarks of Cancer' is an approach of reducing the enormous complexity of cancer to a set of guiding principles. As the underlying mechanism of cancer are portrayed, we find that we gain insight and additional aspects of t…
View article: Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review
Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review Open
Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possib…
View article: 175P MicroRNA-548c: An immune-activator microRNA at the tumor microenvironment and immune milieu of breast cancer
175P MicroRNA-548c: An immune-activator microRNA at the tumor microenvironment and immune milieu of breast cancer Open
Cancer cells evade the human immune system by manipulating the tumor-immune microenvironment (TIME) via suppressing the immuno-activator and promoting the immune-suppressive mediators. Hence, targeting immuno-modulatory factors became an i…
View article: Dual targeting of H2S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer
Dual targeting of H2S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer Open
This study sheds light on the reciprocal relationship between CBS and CSE and on the importance of their dual targeting, particularly in TNBC. It also postulates miR-939-5p as a potent dual repressor for CBS and CSE overcoming their redund…
View article: 26P 3MST: A potential workhorse in H2S signaling trimmed by microRNA-548 in breast cancer
26P 3MST: A potential workhorse in H2S signaling trimmed by microRNA-548 in breast cancer Open
View article: Translational molecular imaging and drug development in Parkinson’s disease
Translational molecular imaging and drug development in Parkinson’s disease Open
View article: Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery
Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery Open
Pediatric primary brain tumors represent a real challenge in the oncology arena. Besides the psychosocial burden, brain tumors are considered one of the most difficult-to-treat malignancies due to their sophisticated cellular and molecular…
View article: Circular RNAs: New layer of complexity evading breast cancer heterogeneity
Circular RNAs: New layer of complexity evading breast cancer heterogeneity Open
View article: Assessment of cholesterol homeostasis in the living human brain
Assessment of cholesterol homeostasis in the living human brain Open
Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily e…
View article: Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences
Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences Open
Age and Gender are vital determinants for the micronutrient demands of normal indviduals. Among these micronutrients are vitamins that are required in small amounts for optimum metabolism, homeostasis, and a healthy lifestyle, acting as co…
View article: The bacteriophage decides own tracks: When they are with or against the bacteria
The bacteriophage decides own tracks: When they are with or against the bacteria Open
View article: Encapsulation of E. coli phage ZCEC5 in chitosan–alginate beads as a delivery system in phage therapy
Encapsulation of E. coli phage ZCEC5 in chitosan–alginate beads as a delivery system in phage therapy Open