Explanipedia

Balancing Early Detection and Overtreatment in Prostate Cancer: The Emerging Role of EpihTERT Open

Simeon Santourlidis, Marcos J. Araúzo‐Bravo, Mohamed Hassan · 2025

Prostate Cancer (PCa) screening using Prostate-Specific Antigen (PSA) has significantly improved early detection but has also led to substantial overdiagnosis and overtreatment, particularly of indolent tumors. While active surveillance an…

Mucosal Melanoma: Mechanisms of Its Etiology, Progression, Resistance and Therapy Open

Sofie-Yasmin Hassan, Thomas W. Flanagan, Sarah-Lilly Hassan, Sybille Facca, Youssef Haïkel , et al. · 2025

Mucosal melanoma (MM) is a rare, aggressive cancer whose incidence has increased continuously over the years. This subtype of melanoma arises from melanocytes on hairless surfaces, typically in the respiratory tract, gastrointestinal (GI) …

Incidence And Determinants Of Postoperative Sore Throat At Mogadishu Somali-Türkiye Recep Tayyip Erdoğan Training And Research Hospital Open

Ahmed Hussein, Ijlal Akbar Ali, Nasra Ahmed Diblawe, Mohamed Hussein Nur, Abdiaziz Abdullahi Abshir , et al. · 2025

Not applicable.

Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms Open

Mohamed Hassan, Thomas W. Flanagan, Abdulaziz M. Eshaq, Osama K. Altamimi, Hassan Altalag , et al. · 2025

Prostate cancer (PCa) accounts for roughly 15% of diagnosed cancers among men, with disease incidence increasing worldwide. Age, family history and ethnicity, diet, physical activity, and chemoprevention all play a role in reducing PCa ris…

Immune Checkpoint Inhibitor-Associated Cutaneous Adverse Events: Mechanisms of Occurrence Open

Abdulaziz M. Eshaq, Thomas W. Flanagan, Anass Abbad, Zain Alabden A. Makarem, Mohammed S. Bokir , et al. · 2024

Immunotherapy, particularly that based on blocking checkpoint proteins in many tumors, including melanoma, Merkel cell carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast (TNB cancer), renal cancer, and gastrointestinal a…

Non-Receptor Tyrosine Kinases: Their Structure and Mechanistic Role in Tumor Progression and Resistance Open

Abdulaziz M. Eshaq, Thomas W. Flanagan, Sofie-Yasmin Hassan, Sara A. Al Asheikh, Waleed Alamoudi , et al. · 2024

Protein tyrosine kinases (PTKs) function as key molecules in the signaling pathways in addition to their impact as a therapeutic target for the treatment of many human diseases, including cancer. PTKs are characterized by their ability to …

hTERT Epigenetics Provides New Perspectives for Diagnosis and Evidence-Based Guidance of Chemotherapy in Cancer Open

Simeon Santourlidis, Marcos J. Araúzo‐Bravo, Robert T. Brodell, Mohamed Hassan, Marcelo L. Bendhack · 2024

Strong epigenetic pan-cancer biomarkers are required to meet several current, urgent clinical needs and to further improve the present chemotherapeutic standard. We have concentrated on the investigation of epigenetic alteration of the hTE…

CD133-Dependent Activation of Phosphoinositide 3-Kinase /AKT/Mammalian Target of Rapamycin Signaling in Melanoma Progression and Drug Resistance Open

Naji Kharouf, Thomas W. Flanagan, Abdulhadi A. AlAmodi, Youssef Al Hmada, Sofie-Yasmin Hassan , et al. · 2024

Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant activation of PI3K and its downstream pathways. Although the role of PI3K/AKT/mTOR in melanoma progression and drug resistance is well documented, tar…

Mechanisms of Melanoma Progression and Treatment Resistance: Role of Cancer Stem-like Cells Open

Youssef Al Hmada, Robert T. Brodell, Naji Kharouf, Thomas W. Flanagan, Abdulhadi A. AlAmodi , et al. · 2024

Melanoma is the third most common type of skin cancer, characterized by its heterogeneity and propensity to metastasize to distant organs. Melanoma is a heterogeneous tumor, composed of genetically divergent subpopulations, including a sma…

Tumor Microenvironment as a Therapeutic Target in Melanoma Treatment Open

Naji Kharouf, Thomas W. Flanagan, Sofie-Yasmin Hassan, Hosam Shalaby, Marla Khabaz , et al. · 2023

The role of the tumor microenvironment in tumor growth and therapy has recently attracted more attention in research and drug development. The ability of the microenvironment to trigger tumor maintenance, progression, and resistance is the…

Induction of Antimicrobial Protein S100A15 Expression by Oral Microbial Pathogens Is Toll-like Receptors-Dependent Activation of c-Jun-N-Terminal Kinase (JNK), p38, and NF-κB Pathways Open

Denis Selimović, Naji Kharouf, Florence Carrouel, Sofie-Yasmin Hassan, Thomas W. Flanagan , et al. · 2023

The antimicrobial protein S100A15 belongs to the S100 family, which is differentially expressed in a variety of normal and pathological tissues. Although the function of S100A15 protein has been discussed in several studies, its induction …

Antimicrobial Proteins: Structure, Molecular Action, and Therapeutic Potential Open

Mohamed Hassan, Thomas W. Flanagan, Naji Kharouf, Christelle Bertsch, Davide Mancino , et al. · 2022

Second- and third-line treatments of patients with antibiotic-resistant infections can have serious side effects, such as organ failure with prolonged care and recovery. As clinical practices such as cancer therapies, chronic disease treat…

Retraction Note: Aging-associated distinctive DNA methylation changes of LINE-1 retrotransposons in pure cell-free DNA from human blood Open

Wardah Mahmood, Lars Erichsen, Pauline Ott, Wolfgang A. Schulz, Johannes Fischer , et al. · 2022

Epigenetics in the Diagnosis and Therapy of Malignant Melanoma Open

Simeon Santourlidis, Wolfgang A. Schulz, Marcos J. Araúzo‐Bravo, Daniela Gerovska, Pauline Ott , et al. · 2022

Epigenetic mechanisms are fundamentally important for cancer initiation and development. However, a survey of the literature reveals that, to date, they appear less comprehensively investigated in melanoma than in many other cancers, e.g.,…

RETRACTED ARTICLE: Aging-associated distinctive DNA methylation changes of LINE-1 retrotransposons in pure cell-free DNA from human blood Open

Wardah Mahmood, Lars Erichsen, Pauline Ott, Wolfgang A. Schulz, Johannes Fischer , et al. · 2020

Effect of Pre-Operatory Low-Level Laser Therapy on Pain, Swelling, and Trismus Associated with Third-Molar Surgery Open

Mohamed Hassan · 2020

Objectives:The extraction of impacted third molars is commonly associated to pain, edema, trismus, limited jaw opening and movements.The objectives of this study is to verify if pre-surgical low-level laser therapy (LLLT) associated with t…

Basic Hallmarks of Urothelial Cancer Unleashed in Primary Uroepithelium by Interference with the Epigenetic Master Regulator ODC1 Open

Lars Erichsen, Hans‐Helge Seifert, Wolfgang A. Schulz, Michèle J. Hoffmann, Günter Niegisch , et al. · 2020

Tumor necrosis factor-α triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial- and non-mitochondrial-dependent pathways Open

Denis Selimović, R.U. Wahl, Emmanuelle Ruiz, Rizwan Aslam, Thomas W. Flanagan , et al. · 2019

Head and neck squamous cell carcinoma (HNSCC) remains one of the most common malignancies worldwide. Although the treatment outcomes of HNSCC have improved in recent years, the prognosis of patients with advanced-stage disease remains poor…

MEF2B is a member of the BCL6 gene transcriptional complex and induces its expression in diffuse large B-cell lymphoma of the germinal center B-cell-like type Open

Siraj M. El Jamal, Zakaria Grada, Mohamed H. El Dinali, He Zhou, Sofie-Yasmin Hassan , et al. · 2018

Genetic Study of Some Egyptian Crabs Species in the Fisheries Grounds Open

Mohamed Hassan, M. Megahed, Sandra Au, Eunice Chizuru Au · 2018

The Random Amplification of Polymorphic DNA-Polymerase Chain Reaction (RAPD-PCR) analyses were applied for studying 7 Egyptian populations of crab species.The genetic distance (GD) among close collection sites was small among location 1, 2…

Author Correction: Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis Open

Lars Erichsen, Foued Ghanjati, Agnes Beermann, Cédric Poyet, Thomas Hermanns , et al. · 2018

Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis Open

Lars Erichsen, Foued Ghanjati, Agnes Beermann, Cédric Poyet, Thomas Hermanns , et al. · 2018

Genome-wide hypomethylation of LINE-1 and Alu retroelements in cell-free DNA of blood is an epigenetic biomarker of human aging Open

Lars Erichsen, Agnes Beermann, Marcos J. Araúzo‐Bravo, Mohamed Hassan, Mohamed A. Dkhil , et al. · 2018

Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies Open

Youssef Alhmada, Denis Selimović, Fadi Murad, Sarah-Lilly Hassan, Youssef Haikel , et al. · 2017

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruri…

Hypoxia on the Expression of Hepatoma Upregulated Protein in Prostate Cancer Cells Open

Ingrid Espinoza, Marcelo J. Sakiyama, Tangeng Ma, Logan Fair, Xinchun Zhou , et al. · 2016

Hepatoma upregulated protein (HURP) is a multifunctional protein with clinical promise. This protein has been demonstrated to be a predictive marker for the outcome in high-risk prostate cancer (PCa) patients, besides being a resistance fa…

Cover Image, Volume 117, Number 6, June 2016 Open

Mohamed Hassan, Abdelouahid El Khattouti, Ahmed Ejaeidi, Tangeng Ma, W.A. Day , et al. · 2016

The cover image, by Christian Gomez et al., is based on the Article Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells, DOI: 10.1002/jcb.25419.

Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways Open

Siraj M. El Jamal, Erin B. Taylor, Zakaria Y. Abd Elmageed, Abdulhadi A. AlAmodi, Denis Selimović , et al. · 2016

In addition to the elucidation of the role of IDO in the modulation of apoptosis, our study provides new insights into the molecular mechanisms of IFNγ-induced apoptosis of HNSCC cells during the course of immune therapy.

Effects of oxygen on the antigenic landscape of prostate cancer cells Open

Tangeng Ma, Claire A. Schreiber, Gaylord J. Knutson, Abdelouahid El Khattouti, Marcelo J. Sakiyama , et al. · 2015

Imiquimod‐induced apoptosis of melanoma cells is mediated by <span>ER</span> stress‐dependent Noxa induction and enhanced by <span>NF</span>‐κB inhibition Open

Abdelouahid El‐Khattouti, Denis Selimović, Matthias Hannig, Erin B. Taylor, Zakaria Y. Abd Elmageed , et al. · 2015

Melanoma is characterized by dysregulated intracellular signalling pathways including an impairment of the cell death machinery, ultimately resulting in melanoma resistance, survival and progression. This explains the tumour's extraordinar…

Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target Open

Abdelouahid El‐Khattouti, Mohamed Hassan, Christian R. Gómez · 2015

Incidence of most common cancers increases with age due to accumulation of damage to cells and tissues. Stroma, the structure close to the basement membrane, is gaining increased attention from clinicians and researchers due to its increas…

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