Abdollah Jafarzadeh
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View article: The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050
The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050 Open
Wellcome Trust, and the UK Department of Health and Social Care using aid funding managed by the Fleming Fund.
View article: Leptin enhances the efficacy of glucantime to modulate macrophage polarization toward the M1 phenotype in Leishmania tropica-infected macrophages
Leptin enhances the efficacy of glucantime to modulate macrophage polarization toward the M1 phenotype in Leishmania tropica-infected macrophages Open
Background Macrophages are essential immune cells during Leishmania infection, as their polarization toward M1/M2 phenotypes determines disease outcome. This study aimed to investigate the modulatory effects of leptin, alone and in combina…
View article: Regulation and function of microRNA-152 in various types of cancers: its upstream regulators and downstream targets
Regulation and function of microRNA-152 in various types of cancers: its upstream regulators and downstream targets Open
View article: A reappraisal of the contribution of Th9 cells and interleukin-9 to the pathogenesis of rheumatoid arthritis
A reappraisal of the contribution of Th9 cells and interleukin-9 to the pathogenesis of rheumatoid arthritis Open
Interleukin-9 (IL-9), the principal cytokine of Th9 cells, influences a vast range of functions due to the widespread expression of its receptor on various immune and non-immune cell types. Th9 cells and IL-9 play a detrimental role in the…
View article: Machine learning in obsessive-compulsive disorder medications
Machine learning in obsessive-compulsive disorder medications Open
View article: PD-1/PD-L1 and PD-1/PD-L2 axes-targeted anti-leishmanial therapy
PD-1/PD-L1 and PD-1/PD-L2 axes-targeted anti-leishmanial therapy Open
Although programmed cell death protein-1 (PD-1) is expressed on CD4+ T, CD8+ T and B cells, the T cell expression of PD-1 and macrophages’ expression of its ligands- PD-L1 and PD-L2 increase during leishmaniasis. The PD-1/PD-L1 interaction…
View article: Role of Interleukin-17 family cytokines in disease severity of patients with knee osteoarthritis
Role of Interleukin-17 family cytokines in disease severity of patients with knee osteoarthritis Open
Background Interleukin-17 (IL-17) family plays a role in the pathogenesis of knee osteoarthritis (KOA) by contributing to the inflammatory and destructive processes in the affected joint. This study aimed to measure levels of IL-17 A and I…
View article: Cutaneous Leishmaniasis Hampers COVID-19: A Controlled Cross-Sectional Study in High-Burden Endemic Areas of Iran
Cutaneous Leishmaniasis Hampers COVID-19: A Controlled Cross-Sectional Study in High-Burden Endemic Areas of Iran Open
View article: Co-Infection of COVID-19, Influenza and RSV: How Non-pharmaceutical Therapeutic Approaches Such as Low Dose Radiation Therapy Can be A Game Changing Strategy
Co-Infection of COVID-19, Influenza and RSV: How Non-pharmaceutical Therapeutic Approaches Such as Low Dose Radiation Therapy Can be A Game Changing Strategy Open
Non-pharmaceutical interventions (NPIs), such as social distancing, were previously reported to play a significant role in diminishing the transmission of COVID-19. However, updated guidelines highlight the elimination of social distancing…
View article: Contemporaneous SARS-CoV-2-Neutralizing Antibodies Mediated by N-glycan Shields
Contemporaneous SARS-CoV-2-Neutralizing Antibodies Mediated by N-glycan Shields Open
Mutations and the glycosylation of epitopes can convert immunogenic epitopes into non-immunogenic ones via natural selection or evolutionary pressure, thereby decreasing their sensitivity to neutralizing antibodies. Based on Thomas Francis…
View article: Modulation of semaphorin 3C & 4D expression in cancerous tissues from individuals with laryngeal squamous cell carcinoma
Modulation of semaphorin 3C & 4D expression in cancerous tissues from individuals with laryngeal squamous cell carcinoma Open
Background & objectives: Semaphorins were initially characterized as axon guidance factors but were subsequently implicated in the regulation of immune responses, angiogenesis, organ formation and a variety of other physiological and devel…
View article: Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis
Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis Open
Radiotherapy can reduce fatigue and EDSS in patients with SPMS. The age and gender of patients may influence the LDR efficacy.
View article: ABO Blood System Associated with Susceptibility, and Rhesus (Rh) Status Associated with Disease Severity in COVID-19 Patients, (Southeast of Iran)
ABO Blood System Associated with Susceptibility, and Rhesus (Rh) Status Associated with Disease Severity in COVID-19 Patients, (Southeast of Iran) Open
ABO Blood System Associated with Susceptibility, and Rhesus (Rh) Status Associated with Disease Severity in COVID-19 Patients, (Southeast of Iran)
View article: Interferon-γ-Treated Mesenchymal Stem Cells Modulate the T Cell-Related Chemokines and Chemokine Receptors in an Animal Model of Experimental Autoimmune Encephalomyelitis
Interferon-γ-Treated Mesenchymal Stem Cells Modulate the T Cell-Related Chemokines and Chemokine Receptors in an Animal Model of Experimental Autoimmune Encephalomyelitis Open
Background Mesenchymal stem cells (MSCs) modulate immune responses, and their immunomodulatory potential can be enhanced using inflammatory cytokines. Here, the modulatory effects of IFN-γ-licensed MSCs on expression of T cell-related chem…
View article: Time Reveals the Truth! What Treatments for COVID-19 Were Quickly Abandoned, and Which Methods, Contrary to Popular Belief, Are Still Flourishing?
Time Reveals the Truth! What Treatments for COVID-19 Were Quickly Abandoned, and Which Methods, Contrary to Popular Belief, Are Still Flourishing? Open
During the early days of the COVID-19 pandemic, low dose radiation therapy (LDRT) was proposed as a potentially effective treatment method. To minimize potential toxicity, the initial treatment approach involved a few mGy of adapting radia…
View article: Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective
Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective Open
The largest universal immunization in history has occurred as a result of the COVID-19 pandemic. The developed COVID-19 vaccines have been shown to provide protection against severe forms of COVID-19 by inducing anti-spike neutralizing ant…
View article: MicroRNA-383: A tumor suppressor miRNA in human cancer
MicroRNA-383: A tumor suppressor miRNA in human cancer Open
Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer. MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the mRNA of some pro-tumor genes to attenuate several cancer-related p…
View article: Development and exacerbation of autoimmune hemolytic anemia following <scp>COVID</scp>‐19 vaccination: A systematic review
Development and exacerbation of autoimmune hemolytic anemia following <span>COVID</span>‐19 vaccination: A systematic review Open
Autoimmune hemolytic anemia (AIHA) is caused by the production of autoantibodies against RBCs. COVID‐19 vaccines can reduce the risk of severe disease, however, various adverse effects such as AIHA were observed following vaccination. This…
View article: Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis
Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis Open
As effector innate immune cells and as a host to the protozoan parasite Leishmania , macrophages play a dual role in antileishmanial immunoregulation. The 2 key players in this immunoregulation are the macrophage-expressed microRNAs (miRNA…
View article: COVID-19 cases, hospitalizations and deaths after vaccination: a cohort event monitoring study, Islamic Republic of Iran
COVID-19 cases, hospitalizations and deaths after vaccination: a cohort event monitoring study, Islamic Republic of Iran Open
The rates of contracting COVID-19 after vaccination were relatively high. SARS-CoV-2 Vaccine (Vero Cell) provided lower protection against COVID-19 than other vaccines. People with comorbidities had higher risks of contracting COVID-19 and…
View article: COVID-19 Update: The Golden Time Window for Pharmacological Treatments and Low Dose Radiation Therapy
COVID-19 Update: The Golden Time Window for Pharmacological Treatments and Low Dose Radiation Therapy Open
At the beginning of the COVID-19 emergence, many scientists believed that, thanks to the proofreading enzyme of SARS-CoV-2, the virus would not have many mutations. Our team introduced the concept of radiation at extremely low doses in an …
View article: Interplays between non-coding RNAs and chemokines in digestive system cancers
Interplays between non-coding RNAs and chemokines in digestive system cancers Open
Within tumors, chemokines and their cognate receptors are expressed by infiltrated leukocytes, cancerous cells, and related cells of stroma, like tumor-associated fibroblasts and tumor-associated macrophages. In malignancies, the altered e…
View article: Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer
Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer Open
Cimetidine and ibuprofen exhibit immunomodulatory effects as an antagonist of histamine H2 receptor, and a cyclooxygenase inhibitor, respectively. Here, the effects of cimetidine and ibuprofen on some effector T cell-related parameters wer…
View article: Reduced Expression of Natural Killer Cell-Related Activating Receptors by Peripheral Blood Mononuclear Cells from Patients with Breast Cancer and Their Improvement by Zoledronic Acid
Reduced Expression of Natural Killer Cell-Related Activating Receptors by Peripheral Blood Mononuclear Cells from Patients with Breast Cancer and Their Improvement by Zoledronic Acid Open
Expression of NK cell-related activating receptors decreased in BC patients. ZOL can improve the expression of NK activating receptors.
View article: SARS-CoV-2 Infection: A Possible Risk Factor for Incidence and Recurrence of Cancers
SARS-CoV-2 Infection: A Possible Risk Factor for Incidence and Recurrence of Cancers Open
COVID-19 and malignancy can affect the susceptibility of one another. Clinically recovered COVID-19 individuals display immune abnormalities that persist several months after discharge. The lymphopenia-related immunosuppression, functional…
View article: Thyroid dysfunction following vaccination with COVID-19 vaccines: a basic review of the preliminary evidence
Thyroid dysfunction following vaccination with COVID-19 vaccines: a basic review of the preliminary evidence Open
View article: Development of anti-rituximab antibodies in rituximab-treated patients: Related parameters & consequences
Development of anti-rituximab antibodies in rituximab-treated patients: Related parameters & consequences Open
The utilization of the monoclonal antibodies (mAbs) as therapeutic agents is one of the most favourable fields in immunotherapy. The immunogenicity of mAbs is one of the major parameters that may restrict their therapeutic and diagnostic a…
View article: CCR2 and DPP9 expression in the peripheral blood of COVID-19 patients: Influences of the disease severity and gender
CCR2 and DPP9 expression in the peripheral blood of COVID-19 patients: Influences of the disease severity and gender Open
View article: Effect of turmeric extract on bone healing in an experimental model of femoral bone fracture.
Effect of turmeric extract on bone healing in an experimental model of femoral bone fracture. Open
Our findings indicated the turmeric ability to facilitate bone hemostasis and optimize the expression of key markers involved in the bone metabolism.
View article: Dysregulated expression and functions of microRNA-330 in cancers: A potential therapeutic target
Dysregulated expression and functions of microRNA-330 in cancers: A potential therapeutic target Open