Ajmal Khan
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View article: Outcome of Open Reduction and Internal Fixation by Using One Titanium Plate and Archbar for the Management of Mandibular Fractures in Symphyseal and Parasymphyseal Region
Outcome of Open Reduction and Internal Fixation by Using One Titanium Plate and Archbar for the Management of Mandibular Fractures in Symphyseal and Parasymphyseal Region Open
OBJECTIVES To determine nerve injury, malocclusion, and non-union of ORIF using a single miniplate and arch bar in the treatment of mandibular fractures in the parasymphyseal and symphyseal regions. METHODOLOGY This descriptive cross-secti…
View article: Identifying potent natural inhibitors of the hepatitis C virus NS3 protein using multiple computational and molecular approaches
Identifying potent natural inhibitors of the hepatitis C virus NS3 protein using multiple computational and molecular approaches Open
The NS3 protein of hepatitis C virus is an appealing target for therapeutic research because of its notable role in hepatitis C virus (HCV) replication and immune evasion. We employed a comprehensive interdisciplinary strategy to discover …
View article: Prevalence and Risk Factors for Relapse in Pulmonary Sarcoidosis: The First Systematic Review, Meta-analysis, and Future Directions
Prevalence and Risk Factors for Relapse in Pulmonary Sarcoidosis: The First Systematic Review, Meta-analysis, and Future Directions Open
Background and Aim Relapses are known to adversely affect the prognosis of patients with pulmonary sarcoidosis (PS). However, a systematic review or meta-analysis on the subject is not yet available in the literature. Research question Wha…
View article: Molecular assessment of carbapenem-resistant and ESBL Klebsiella pneumoniae clinical isolates to decipher the correlation of antimicrobial resistance with virulence traits
Molecular assessment of carbapenem-resistant and ESBL Klebsiella pneumoniae clinical isolates to decipher the correlation of antimicrobial resistance with virulence traits Open
Klebsiella pneumoniae is a nosocomial pathogen that poses a serious concern due to the high prevalence of extended-spectrum beta-lactamases (ESBL) and carbapenem-resistant K. pneumoniae (CRKP) strains. However, the data on the prevalence o…
View article: Associations of volatile organic compounds with accelerated epigenetic aging in the lungs of smokers and electronic cigarette users
Associations of volatile organic compounds with accelerated epigenetic aging in the lungs of smokers and electronic cigarette users Open
This is the first study reporting associations between smoking/EC-related VOCs and lung biological aging with strong associations in SM, supporting the need for further research on the roles of VOCs-related epigenetic aging and cell senesc…
View article: Artificial Intelligence in Detecting Subclinical Cardiovascular Disease: A New Frontier in Preventive Cardiology
Artificial Intelligence in Detecting Subclinical Cardiovascular Disease: A New Frontier in Preventive Cardiology Open
Introduction: The condition commonly referred to as subclinical cardiovascular disease (SCVD) presents in most instances when the disease is not easily diagnosed and tends to progress to a more severe phase. Early detection has become one …
View article: Cardiovascular Disease in Low and Middle Income Countries: Challenges and Solutions
Cardiovascular Disease in Low and Middle Income Countries: Challenges and Solutions Open
Introduction: Cardiovascular disease (CVD) stands among the principal reasons for death in low- and middle-income countries (LMICs) together with Pakistan. Medical areas with restricted healthcare access, limited resources, and elevated ri…
View article: “Isolation and Characterization of Steroidal Alkaloids from <i>Sarcococca Saligna</i>, Their Antinociceptive, Anti‐Inflammatory, and Gastroprotective Effect in Animal's Model”
“Isolation and Characterization of Steroidal Alkaloids from <i>Sarcococca Saligna</i>, Their Antinociceptive, Anti‐Inflammatory, and Gastroprotective Effect in Animal's Model” Open
In the current research, two steroidal alkaloids (holaphylline (HP) and sarcodine (SD)) were isolated from the methanol extract of Sarcococca saligna and evaluated for analgesic, anti‐inflammatory, and gastro‐protective activities in anima…
View article: Microwave-assisted synthesis of superabsorbent agar-based magnetic composite hydrogel for drug delivery and anti-inflammatory studies
Microwave-assisted synthesis of superabsorbent agar-based magnetic composite hydrogel for drug delivery and anti-inflammatory studies Open
This study presents the synthesis of novel super absorbent ager base magnetic composite hydrogel (AMHs) through a microwave assisted polymerization technique. The composite hydrogels (control, MT, MS, and MN) were synthesized from 2-acryla…
View article: Isolation and characterization of bioactive constituents from <i>Withania coagulans</i> Dunal with antioxidant and multifunctional enzyme inhibition potential, supported by docking, MD, and DFT studies
Isolation and characterization of bioactive constituents from <i>Withania coagulans</i> Dunal with antioxidant and multifunctional enzyme inhibition potential, supported by docking, MD, and DFT studies Open
Withania coagulans Dunal is a medicinal plant with potential therapeutic applications in neurodegenerative and metabolic disorders.
View article: Design and synthesis of terephthalic dihydrazide analogues as dual inhibitors of glycation and urease
Design and synthesis of terephthalic dihydrazide analogues as dual inhibitors of glycation and urease Open
The overexpression of urease is the root cause of peptic ulcers and gastritis.
View article: Dental Anomalies in Children with Unilateral and Bilateral Cleft Lip and Palate
Dental Anomalies in Children with Unilateral and Bilateral Cleft Lip and Palate Open
Background: Dental anomalies is common feature of cleft lip and palate cases. Clefting is not an isolated condition but rather part of a broader spectrum of malformations involving both facial structures and tooth developmentObjective: To …
View article: Speckle‐Tracking Echocardiography as an Effective Screening Tool for Cardiac Involvement Among Patients With Systemic Sarcoidosis in an Indian Cohort: A Prospective Observational Study
Speckle‐Tracking Echocardiography as an Effective Screening Tool for Cardiac Involvement Among Patients With Systemic Sarcoidosis in an Indian Cohort: A Prospective Observational Study Open
Introduction Diagnosing cardiac sarcoidosis (CS) is challenging due to the lack of a sensitive gold standard diagnostic test. Although advanced imaging techniques like cardiac magnetic resonance imaging (MRI) (cardiovascular magnetic reson…
View article: Design, synthesis, QSAR modelling and molecular dynamic simulations of N-tosyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors
Design, synthesis, QSAR modelling and molecular dynamic simulations of N-tosyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors Open
Tyrosinase is an enzyme crucial for the progression of melanogenesis. Immoderate production of melanin may be the cause of hyperpigmentation and darkening leading to skin diseases. Tyrosinase is the most researched target for suppressing m…
View article: Efficient defluoridation of drinking water using mesoporous magnetic malachite nanocomposites
Efficient defluoridation of drinking water using mesoporous magnetic malachite nanocomposites Open
The study evaluated the efficacy of magnetic mesoporous Malachite nanoparticles (NPs) in eliminating fluoride (F−) from drinking water. Screening experiments were conducted to gauge the F− adsorption capabilities of the synthesized materia…
View article: Analyzing the Role of Mechanical Bowel Preparation on Surgical Outcomes in Colorectal Surgery
Analyzing the Role of Mechanical Bowel Preparation on Surgical Outcomes in Colorectal Surgery Open
Despite improved postoperative recovery from the use of minimally invasive procedures and enhanced recovery after surgery protocols in recent decades, colectomy is still associated with morbidity. Surgical site infections range from trivia…
View article: Occurrence and antimicrobial resistance of Campylobacter jejuni isolated from poultry and hospitalized diarrheal patients in Pakistan
Occurrence and antimicrobial resistance of Campylobacter jejuni isolated from poultry and hospitalized diarrheal patients in Pakistan Open
The leading human enteropathogen Campylobacter jejuni (C. jejuni) is recognized as a major public-health concern, due to emerging multidrug resistant (MDR) strains, and associated post-infectious complications. Therefore, the present study…
View article: Corrigendum to “Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity” [Heliyon 10(11) 15th June 2024, e31671]
Corrigendum to “Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity” [Heliyon 10(11) 15th June 2024, e31671] Open
[This corrects the article DOI: 10.1016/j.heliyon.2024.e31671.].
View article: Structural, dynamic behaviour, in-vitro and computational investigations of Schiff’s bases of 1,3-diphenyl urea derivatives against SARS-CoV-2 spike protein
Structural, dynamic behaviour, in-vitro and computational investigations of Schiff’s bases of 1,3-diphenyl urea derivatives against SARS-CoV-2 spike protein Open
The COVID-19 has had a significant influence on people's lives across the world. The viral genome has undergone numerous unanticipated changes that have given rise to new varieties, raising alarm on a global scale. Bioactive phytochemicals…
View article: <i>Trans</i>-Chalcone (1–3-diphenyl-2-propen-1-one) as a Therapeutic Candidate in Joint Inflammation via Reduction of TNF-α, IL-1β, IL-6, and IL-17 in Rodents: An <i>In Vivo</i> Study by RT-PCR and ELISA analysis
<i>Trans</i>-Chalcone (1–3-diphenyl-2-propen-1-one) as a Therapeutic Candidate in Joint Inflammation via Reduction of TNF-α, IL-1β, IL-6, and IL-17 in Rodents: An <i>In Vivo</i> Study by RT-PCR and ELISA analysis Open
Autoimmune disorders include vast and distinct illnesses and are characterized by an immune system-mediated attack on the body's own tissues. Because of their ability to impact any portion of the body, their clinical symptoms are incredibl…
View article: Optimizing the fluoride removal from drinking water through adsorption with mesoporous magnetic calcite nanocomposites
Optimizing the fluoride removal from drinking water through adsorption with mesoporous magnetic calcite nanocomposites Open
Fluoride (F−) contamination in groundwater is a global concern arising from natural processes and human activities. This study investigates the adsorption of F− using surface-activated magnetic calcite nanocomposites (NCs) synthesized via …