Abdulelah Saleh Alshawli
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View article: Evaluation of potential substrates and inhibitors of MRP2 transporter to predict effective combinatorial chemotherapeutic agents for treating MRP2-associated non-responsive colorectal cancer
Evaluation of potential substrates and inhibitors of MRP2 transporter to predict effective combinatorial chemotherapeutic agents for treating MRP2-associated non-responsive colorectal cancer Open
Colorectal cancer (CRC) is a significant cause of death globally, due to the emergence of multidrug resistance (MDR), which limits the effectiveness of conventional chemotherapy. Multidrug resistance-associated protein 2 (MRP2) plays a cri…
View article: Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia
Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia Open
Despite advancements in therapeutics, early diagnosis of ovarian cancer (OC) remains a challenge due to its asymptomatic progression and it is often diagnosed at an advanced stage. Interleukin-8 (IL-8), a pro-inflammatory chemokine with an…
View article: Enhancing MS‐275 Anticancer Activity: Encapsulation of MS‐275 in TPGS Micelles Demonstrated High Efficiency
Enhancing MS‐275 Anticancer Activity: Encapsulation of MS‐275 in TPGS Micelles Demonstrated High Efficiency Open
MS‐275, a histone deacetylase inhibitor, has proven anticancer activities against various malignancies. However, its clinical application has been constrained by dose‐limiting toxicity, off‐target effects, and variable clinical outcomes. C…
View article: Interaction Analysis of MRP1 with Anticancer Drugs Used in Ovarian Cancer: In Silico Approach
Interaction Analysis of MRP1 with Anticancer Drugs Used in Ovarian Cancer: In Silico Approach Open
Multidrug resistance (MDR) is one of the major therapeutic challenges that limits the efficacy of chemotherapeutic response resulting in poor prognosis of ovarian cancer (OC). The multidrug resistance protein 1 (MRP1) is a membrane-bound A…
View article: Favourable Prognosis Value of Matrix Metalloproteinase-10 Overexpression in Urinary Bladder Cancer
Favourable Prognosis Value of Matrix Metalloproteinase-10 Overexpression in Urinary Bladder Cancer Open
Matrix metalloproteinase-10 is an extracellular matrix degradation enzyme that facilitates cell invasion in many cancers and is associated with poor clinical outcomes. In urinary bladder cancer, the clinical importance of matrix metallopro…
View article: Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes
Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes Open
Background Repressor element 1‐silencing transcription factor (REST) acts as a transcriptional repressor by recruiting several chromatin modifiers, including histone deacetylase (HDAC). Elevated REST expression in medulloblastoma has been …
View article: Investigating the cellular and anti-cancer effects of REST and HDAC inhibition in Daoy medulloblastoma cells
Investigating the cellular and anti-cancer effects of REST and HDAC inhibition in Daoy medulloblastoma cells Open
REST is a transcriptional repressor protein and has been suggested to maintain the self-renewal potential of several brain tumours including medulloblastoma. REST represses transcription by recruiting several chromatin modifiers, including…