Abdullah Al Nahain
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View article: Efficient Synthesis of Fluorogenic Substrates for Mucopolysaccharidosis (MPS) IIIA and IIIB Via Aromatic α-Glycosylation with Thioglycosyl Donors
Efficient Synthesis of Fluorogenic Substrates for Mucopolysaccharidosis (MPS) IIIA and IIIB Via Aromatic α-Glycosylation with Thioglycosyl Donors Open
Sanfilippo syndrome (Mucopolysaccharidosis type III, or MPS III) is an inherited neurodegenerative disorder resulting from mutations in genes encoding lysosomal enzymes that sequentially degrade heparan sulfate. Currently, there are no app…
View article: A Novel Series of Synthetic Heparin‐Mimetics–Itaconic Acid‐Containing Copolymers for Targeting Tumor Cell Coagulability and Metastasis
A Novel Series of Synthetic Heparin‐Mimetics–Itaconic Acid‐Containing Copolymers for Targeting Tumor Cell Coagulability and Metastasis Open
Thromboses are potentially fatal complication in malignant tumor diseases. Today, oral anticoagulants are considered equivalent alternatives to low molecular weight heparin (LMWH) in guideline‐based treatments of cancer‐associated thrombos…
View article: Sulfonated RAFT Copolymers as Heparin Mimetics: Synthesis, Reactivity Ratios, and Anticoagulant Activity
Sulfonated RAFT Copolymers as Heparin Mimetics: Synthesis, Reactivity Ratios, and Anticoagulant Activity Open
The glycosaminoglycan heparin is a clinically important anticoagulant drug, primarily used to reduce the risk of blood clots (thrombosis) during surgery. Despite its importance in medicine and its continuous use over many decades, heparin …