Ziyad S. Almalki
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View article: A hierarchical and configurational analysis of Health Technology Assessment outcomes for cell and gene therapies
A hierarchical and configurational analysis of Health Technology Assessment outcomes for cell and gene therapies Open
Background Cell and gene therapies (CGTs) challenge traditional Health Technology Assessment (HTA), creating a fragmented global access landscape. This study identifies the determinants of CGT reimbursement outcomes by quantifying the infl…
View article: Challenges in evaluation and reimbursement of drugs for rare diseases in Saudi Arabia: a Delphi expert consensus
Challenges in evaluation and reimbursement of drugs for rare diseases in Saudi Arabia: a Delphi expert consensus Open
This study provides the first consensus on challenges in DRD evaluation and reimbursement in Saudi Arabia. Addressing these issues through policy reforms, stakeholder collaboration, and data infrastructure enhancement is crucial to optimis…
View article: The association between parenteral antimicrobials and bacterial resistance at King Khaled Hospital in Al-Kharj: A retrospective cohort study
The association between parenteral antimicrobials and bacterial resistance at King Khaled Hospital in Al-Kharj: A retrospective cohort study Open
Antimicrobial resistance (AMR) is rising alarmingly in Saudi Arabia, as evidenced by surveillance data. This retrospective cohort study evaluated the association between parenteral antimicrobial use and bacterial resistance at King Khaled …
View article: Pharmacists’ self-reported confidence in providing pharmaceutical care on anticoagulants in Saudi Arabia
Pharmacists’ self-reported confidence in providing pharmaceutical care on anticoagulants in Saudi Arabia Open
Background: Anticoagulant therapy is high-risk and requires pharmacists to be highly competent in its management. In Saudi Arabia, the confidence of pharmacists in providing such care is not well-established. This study aimed to assess the…
View article: Perceptions of Parental Needs in General Pediatric Inpatient Units: A Comparative Study Between Nurses and Parents in Saudi Arabia
Perceptions of Parental Needs in General Pediatric Inpatient Units: A Comparative Study Between Nurses and Parents in Saudi Arabia Open
Introduction: Hospitalization of children creates significant emotional and psychological stress for parents, highlighting the importance of addressing their needs in pediatric care settings. Aims: This study examines the perceptions of bo…
View article: Spending, utilization, and price trends for anti-obesity medications in U.S. Medicaid programs: an empirical analysis from 1999 to 2023
Spending, utilization, and price trends for anti-obesity medications in U.S. Medicaid programs: an empirical analysis from 1999 to 2023 Open
Background Obesity poses a significant public health and economic challenge in the United States (U.S.), with rising prevalence, particularly among individuals enrolled in Medicaid—the nation’s public health insurance program for low-incom…
View article: Cost-Utility Analysis of Metabolic Bariatric Surgery for Individuals with Obesity in Saudi Arabia
Cost-Utility Analysis of Metabolic Bariatric Surgery for Individuals with Obesity in Saudi Arabia Open
MBS is a cost-effective intervention compared with standard treatment in the context of the KSA. Efforts should be made to expand earlier and equitable access to MBS for individuals with a BMI > 40 kg/m2 without comorbidities across the co…
View article: Assessing the effects of antidepressant use on stroke recurrence and related outcomes in ischemic stroke patients: a propensity score matched analysis
Assessing the effects of antidepressant use on stroke recurrence and related outcomes in ischemic stroke patients: a propensity score matched analysis Open
The effect of antidepressant use, particularly that of selective serotonin reuptake inhibitors, on stroke outcomes remains unclear. This hospital-based, retrospective, observational study utilized propensity score-matching (PSM) to assess …
View article: Cost-Effectiveness Analysis of Ofatumumab versus Teriflunomide for Relapsing-Remitting Multiple Sclerosis: A 10-Year Markov Model
Cost-Effectiveness Analysis of Ofatumumab versus Teriflunomide for Relapsing-Remitting Multiple Sclerosis: A 10-Year Markov Model Open
This cost-effectiveness analysis demonstrates that ofatumumab is a cost-effective treatment for RRMS in Saudi Arabia, with an ICER below the WTP. Policymakers should consider including ofatumumab in national formularies and prioritize its …
View article: The Burden of Obesity in Saudi Arabia: A Real-World Cost-of-Illness Study
The Burden of Obesity in Saudi Arabia: A Real-World Cost-of-Illness Study Open
Obesity imposes a substantial economic burden on the healthcare system and society in the KSA. Interventions aimed at promoting healthier lifestyles to reduce the prevalence and incidence of obesity and its comorbidities are highly warrant…
View article: Assessment of occupational radiation exposure among various medical professions in interventional cardiology: A five-year study (2018–2022)
Assessment of occupational radiation exposure among various medical professions in interventional cardiology: A five-year study (2018–2022) Open
Occupational radiation exposure in medical settings is a growing concern, especially in interventional cardiology. This study aims to assess the occupational radiation exposure among medical personnel in interventional cardiology from 2018…
View article: The role of fMRI in the mind decoding process in adults: a systematic review
The role of fMRI in the mind decoding process in adults: a systematic review Open
Background Functional magnetic resonance imaging (fMRI) has revolutionized our understanding of brain activity by non-invasively detecting changes in blood oxygen levels. This review explores how fMRI is used to study mind-reading processe…
View article: Effectiveness and Outcomes of Endoscopic Sinus Surgery for Nasal Polyps: A Systematic Review
Effectiveness and Outcomes of Endoscopic Sinus Surgery for Nasal Polyps: A Systematic Review Open
Objectives: To investigate the effectiveness and outcomes of endoscopic sinus surgery (ESS) in patients with nasal polyps. Methods: A thorough search was conducted for pertinent literature using PubMed, SCOPUS, Web of Science, Science Dire…
View article: Willingness to Pay for Telemedicine Services Among Uninsured Individuals in Saudi Arabia: A Cross-Sectional Survey
Willingness to Pay for Telemedicine Services Among Uninsured Individuals in Saudi Arabia: A Cross-Sectional Survey Open
The findings indicate that most respondents hesitated to pay for telemedicine services, with a significant influence from sociodemographic characteristics, underscoring the need to promote telemedicine use among underserved populations and…
View article: Assessment of knowledge of the new pregnancy and lactation labeling rule among pharmacists and physicians in Saudi Arabia
Assessment of knowledge of the new pregnancy and lactation labeling rule among pharmacists and physicians in Saudi Arabia Open
Researchers in Saudi Arabia conducted this study to determine the level of familiarity that pharmacists and physicians possess with the pregnancy and lactation labeling rules established by the Food and Drug Administration. The present stu…
View article: Correction: Beliefs, awareness, use, and factors associated with herbal supplements usage among patients with chronic diseases–A cross-sectional insight from Alkharj, Saudi Arabia
Correction: Beliefs, awareness, use, and factors associated with herbal supplements usage among patients with chronic diseases–A cross-sectional insight from Alkharj, Saudi Arabia Open
[This corrects the article DOI: 10.1371/journal.pone.0295116.].
View article: Prescribing patterns and persistence of biological therapies for psoriasis management: a retrospective cohort study from Saudi Arabia
Prescribing patterns and persistence of biological therapies for psoriasis management: a retrospective cohort study from Saudi Arabia Open
This study shows changing psoriasis treatment patterns with new therapies. Risankizumab demonstrated high long-term persistence, while etanercept and ustekinumab showed declining persistence, suggesting evolving treatment considerations.
View article: Evaluation of time to sputum smear conversion and its association with treatment outcomes among drug-resistant tuberculosis patients: a retrospective record-reviewing study
Evaluation of time to sputum smear conversion and its association with treatment outcomes among drug-resistant tuberculosis patients: a retrospective record-reviewing study Open
Background: This study examined the time to sputum smear and culture conversion and determinants of conversion, as well as variables associated with treatment outcomes among drug-resistant pulmonary tuberculosis (DR-PTB) cases. Methods: Th…
View article: Assessment of Health-Related Quality of Life Among Patients with Chronic Diseases and Its Relationship with Multimorbidity: A Cross-Sectional Study from Saudi Arabia
Assessment of Health-Related Quality of Life Among Patients with Chronic Diseases and Its Relationship with Multimorbidity: A Cross-Sectional Study from Saudi Arabia Open
The present study provided preliminary data about the current HRQoL status of individuals with imperfect health and lower HRQoL. In the future, large-scale longitudinal studies are required to investigate the most prevalent chronic disease…
View article: An analysis of the intention of female pharmacy students to work in community pharmacy settings in Saudi Arabia using the theory of planned behavior
An analysis of the intention of female pharmacy students to work in community pharmacy settings in Saudi Arabia using the theory of planned behavior Open
Female pharmacy students in Saudi Arabia had a low intention to work in community pharmacies, a positive attitude toward working in community pharmacies, and perceived no social pressure to work in them. A positive attitude and behavioral …
View article: Beliefs, awareness, use, and factors associated with herbal supplements usage among patients with chronic diseases–A cross-sectional insight from Alkharj, Saudi Arabia
Beliefs, awareness, use, and factors associated with herbal supplements usage among patients with chronic diseases–A cross-sectional insight from Alkharj, Saudi Arabia Open
Background Herbal supplements (HSs) are used to treat a variety of diseases and ailments. Individuals with chronic diseases are at a higher risk of having adverse events and drug interactions from the use of HSs. Aim This study determined …
View article: Access and Disparities in the Use of Telemedicine Among Patients with Chronic Conditions in Saudi Arabia: A Cross-Sectional Study
Access and Disparities in the Use of Telemedicine Among Patients with Chronic Conditions in Saudi Arabia: A Cross-Sectional Study Open
This study highlights a significant disparity in the utilization of telemedicine services across different populations, primarily due to demographic and socioeconomic factors.
View article: Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis
Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis Open
Ferroptosis is an emerging and novel type of iron-dependent programmed cell death which is mainly caused by the excessive deposition of free intracellular iron in the brain cells. This deposited free iron exerts a ferroptosis pathway, resu…
View article: Effectiveness and safety of edoxaban versus warfarin in patients with nonvalvular atrial fibrillation: a systematic review and meta-analysis of observational studies
Effectiveness and safety of edoxaban versus warfarin in patients with nonvalvular atrial fibrillation: a systematic review and meta-analysis of observational studies Open
Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia type. Patients with AF are often administered anticoagulants to reduce the risk of ischemic stroke due to an irregular heartbeat. We evaluated the efficacy and s…
View article: Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica
Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica Open
Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow charac…