Azra C. Ghani
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View article: Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions
Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions Open
Since their first detection in 2010, Plasmodium falciparum malaria parasites lacking the P. falciparum histidine-rich protein 2 gene ( pfhrp2 ) have been observed in 40 of 47 surveyed countries, as documented by the World Health Organizati…
Seasonal mass vaccination with R21/Matrix-M for malaria elimination (SERVAL): protocol of the cluster randomised trial Open
Introduction Progress in malaria control has stalled since 2015, highlighting the need for new control tools. The R21/Matrix-M (R21) malaria vaccine, a pre-erythrocytic vaccine recently approved by WHO for small children, may be one of the…
Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic Open
COVID-19 has underscored the need for more timely access to vaccines during future pandemics. This has motivated development of broad-spectrum vaccines providing protection against entire viral families, which could be stockpiled and deplo…
View article: Scaling Truth: The Confidence Paradox in AI Fact-Checking
Scaling Truth: The Confidence Paradox in AI Fact-Checking Open
The rise of misinformation underscores the need for scalable and reliable fact-checking solutions. Large language models (LLMs) hold promise in automating fact verification, yet their effectiveness across global contexts remains uncertain.…
View article: Seasonal mass vaccination with R21/Matrix-M for malaria elimination (SERVAL): protocol of the cluster randomised trial
Seasonal mass vaccination with R21/Matrix-M for malaria elimination (SERVAL): protocol of the cluster randomised trial Open
Introduction Progress in malaria control has stalled since 2015, highlighting the need for new control tools. The R21/Matrix-M (R21) malaria vaccine, a pre-erythrocytic vaccine recently approved by WHO for small children, may be one of the…
Incidence of vaginal birth after previous cesarean section and fetal outcomes in a tertiary care hospital in Peshawar. Open
Objective: To determine the frequency of vaginal birth after one cesarean section, along with fetal outcomes. Study Design: Cross-sectional study. Setting: Department of Gynecology and Obstetrics at Hayatabad Medical Complex, Peshawar, Pak…
View article: Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study
Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study Open
Background The pre-erythrocytic malaria vaccine R21/Matrix-M is recommended for young children, who often bear the highest burden, in malaria endemic regions. However, the small proportion of the vaccine-eligible population and waning vacc…
Estimating the potential impact of surveillance test-and-treat posts to reduce malaria in border regions in sub-Saharan Africa: a modelling study Open
Background The last malaria cases in near-elimination settings are often found in international border regions due to the presence of hard-to-reach populations, conflict, uneven intervention coverage, and human migration. Test-and-treat bo…
View article: Correction: Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study
Correction: Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study Open
[This corrects the article DOI: 10.1371/journal.pmed.1004521.].
View article: Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study
Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study Open
Background Gonorrhea is the second most common sexually transmitted disease notified in Singapore in 2023. Evidence suggests that the 4CMenB vaccine designed to protect against Neisseria meningitidis infection may offer partial cross-prote…
Quantifying the potential value of entomological data collection for programmatic decision-making on malaria control in sub-Saharan African settings Open
Background The availability of many tools for malaria control leads to complex decisions regarding the most cost-effective intervention package based on local epidemiology. Mosquito characteristics influence the impact of vector control, b…
View article: Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic
Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic Open
COVID-19 has underscored the need for more timely access to vaccines during future pandemics. This has motivated development of broad-spectrum vaccines providing protection against viral families, which could be stockpiled ahead of an outb…
Estimating the potential impact of surveillance test-and-treat posts to reduce malaria in border regions in sub-Saharan Africa: a modelling study Open
The last malaria cases in near-elimination settings are often found in international border regions due to the presence of hard-to-reach populations, conflict, uneven intervention coverage, and human migration. Test-and-treat border posts …
The potential of gene drive releases in malaria vector species to reduce the malaria burden in different African environments Open
Gene drive technologies are a promising means of malaria control with the potential to cause widespread and sustained reductions in transmission. In real environments, however, gene drive impacts will depend on local ecological and epidemi…
Efficacy and Safety of Double J Stenting (DJS) and Percutaneous Nephrostomy (PCN) in Patients with Obstructive Uropathy Open
Background: Obstructive uropathy is a condition characterized by the blockage of urine flow, which can lead to renal parenchymal damage and, if left untreated, potentially fatal outcomes. The condition arises from various causes, including…
View article: The public health impact and cost-effectiveness of the R21/Matrix-M malaria vaccine: a mathematical modelling study
The public health impact and cost-effectiveness of the R21/Matrix-M malaria vaccine: a mathematical modelling study Open
The Wellcome Trust, the Bill & Melinda Gates Foundation, the UK Medical Research Council, the European and Developing Countries Clinical Trials Partnership 2 and 3, the NIHR Oxford Biomedical Research Centre, and the Serum Institute of Ind…
Author Response: Modeling resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Peer review Author response Article and author information Metrics Abstract Lar…
Modeling resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication Open
Large reductions in the global malaria burden have been achieved, but plateauing funding poses a challenge for progressing towards the ultimate goal of malaria eradication. Using previously published mathematical models of Plasmodium falci…
View article: Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study
Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study Open
Background Vaccines have reduced severe disease and death from Coronavirus Disease 2019 (COVID-19). However, with evidence of waning efficacy coupled with continued evolution of the virus, health programmes need to evaluate the requirement…
Maternal and Fetal Outcome in Cardiac Patients a Cross-Sectional Study at Tertiary Care Setting Open
Background: In low-resource settings, when specialist treatment is unavailable, cardiovascular disease during pregnancy presents severe hazards to the health of both the mother and the fetus. Objective: To assess maternal and fetal outcome…
Author Response: Resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication Open
Large reductions in the global malaria burden have been achieved in the last decades, but plateauing funding poses a challenge for progressing towards the ultimate goal of malaria eradication. We aimed to determine the optimal strategy to …
Reviewer #2 (Public Review): Resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication Open
Large reductions in the global malaria burden have been achieved in the last decades, but plateauing funding poses a challenge for progressing towards the ultimate goal of malaria eradication. We aimed to determine the optimal strategy to …
Resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication Open
Background Large reductions in the global malaria burden have been achieved in the last decades, but plateauing funding poses a challenge for progressing towards the ultimate goal of malaria eradication. We aimed to determine the optimal s…
Reviewer #1 (Public Review): Resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication Open
Large reductions in the global malaria burden have been achieved in the last decades, but plateauing funding poses a challenge for progressing towards the ultimate goal of malaria eradication. We aimed to determine the optimal strategy to …
View article: Global risk of selection and spread of <i>Plasmodium falciparum</i> histidine-rich protein 2 and 3 gene deletions
Global risk of selection and spread of <i>Plasmodium falciparum</i> histidine-rich protein 2 and 3 gene deletions Open
In the thirteen years since the first report of pfhrp2 -deleted parasites in 2010, the World Health Organization (WHO) has found that 40 of 47 countries surveyed worldwide have reported pfhrp2/3 gene deletions. Due to a high prevalence of …
Modeling resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication Open
Large reductions in the global malaria burden have been achieved, but plateauing funding poses a challenge for progressing towards the ultimate goal of malaria eradication. Using previously published mathematical models of Plasmodium falci…