Muhammad Saeed Jan
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View article: Dual-Action Compounds for Glycemic Control: N-Benzyl-2,5-Dioxopyrrolidin-3-yl-Methanesulfonamide and 2-Benzylsuccinimide mimic α-Amylase and α-Glucosidase activities to regulate blood glucose levels
Dual-Action Compounds for Glycemic Control: N-Benzyl-2,5-Dioxopyrrolidin-3-yl-Methanesulfonamide and 2-Benzylsuccinimide mimic α-Amylase and α-Glucosidase activities to regulate blood glucose levels Open
Diabetes mellitus is one of the most alarming metabolic syndromes caused by high blood sugar levels. Herein, we report the identification of two potent antidiabetic agents: N-benzyl-2,5-dioxopyrrolidin-3-yl-methanesulfonamide (NDMS) and 2-…
View article: Phytochemical Screening and Antidiabetic Potential of <i>Paeonia emodi</i> in Alloxan‐Induced Diabetic Rats: Investigative Study Toward Possible Mechanism
Phytochemical Screening and Antidiabetic Potential of <i>Paeonia emodi</i> in Alloxan‐Induced Diabetic Rats: Investigative Study Toward Possible Mechanism Open
Paeonia emodi has long been used in folk medicine to treat a variety of ailments, including diabetes, skin disorders, dropsy, cuts, wounds, ulcers, fever, and blood disorders, etc., which are generally categorized under the complications o…
View article: Racial and Temporal Trends in Mortality from Opioid Use Disorder and cardiorespiratory depression in U.S. Adults: (1999–2023)
Racial and Temporal Trends in Mortality from Opioid Use Disorder and cardiorespiratory depression in U.S. Adults: (1999–2023) Open
View article: Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055
Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055 Open
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View article: Lemongrass Alleviates Primary Dysmenorrhea Symptoms by Reducing Oxidative Stress and Inflammation and Relaxing the Uterine Muscles
Lemongrass Alleviates Primary Dysmenorrhea Symptoms by Reducing Oxidative Stress and Inflammation and Relaxing the Uterine Muscles Open
Primary dysmenorrhea (PD) is characterized by lower abdominal spasms and painful cramps during menstruation in females with a normal pelvic anatomy. Cymbopogon citratus (DC.) Stapf, commonly known as lemongrass, is consumed in the form of …
View article: Assessment of Preclinical Antioxidative and Anti‐Inflammatory Activities of <scp><i>Cornus macrophylla</i></scp> Wall. Bark
Assessment of Preclinical Antioxidative and Anti‐Inflammatory Activities of <span><i>Cornus macrophylla</i></span> Wall. Bark Open
Cornus macrophylla Wall. Bark has been traditionally utilized for its therapeutic properties; however, limited scientific evidence is available that supports its role as having anti‐inflammatory and neuroprotective properties. Exploring th…
View article: CORRELATION OF SERUM URIC ACID LEVEL WITH LEVEL OF URINARY ALBUMIN IN PATIENTS WITH DIABETIC NEPHROPATHY
CORRELATION OF SERUM URIC ACID LEVEL WITH LEVEL OF URINARY ALBUMIN IN PATIENTS WITH DIABETIC NEPHROPATHY Open
Background: Diabetic nephropathy is a leading cause of chronic kidney disease worldwide, contributing significantly to morbidity and mortality among individuals with diabetes mellitus. Uric acid, a final product of purine metabolism, has b…
View article: PREVALENCE OF HEPATITIS B AND C AMONG THALASSEMIC PATIENTS UNDER 12 YEARS CHILDRENS IN DISTRICT SWAT
PREVALENCE OF HEPATITIS B AND C AMONG THALASSEMIC PATIENTS UNDER 12 YEARS CHILDRENS IN DISTRICT SWAT Open
Background: Thalassemia is a group of inherited hemoglobinopathies characterized by defective synthesis of alpha or beta globin chains, leading to microcytic hypochromic anemia. Patients with beta thalassemia major require lifelong blood t…
View article: Antibacterial activity of dietary spices as adjuvants to ciprofloxacin against resistant uropathogenic Escherichia coli
Antibacterial activity of dietary spices as adjuvants to ciprofloxacin against resistant uropathogenic Escherichia coli Open
Urinary tract infections (UTIs), particularly those caused by antibiotic-resistant Escherichia coli, pose a significant global health challenge. This study investigates the potential of dietary spices garlic (Allium sativum) and mint (Ment…
View article: <b>Spectrum of Intradialytic Complications in End-Stage Renal Disease Patients on Maintenance Hemodialysis</b>
<b>Spectrum of Intradialytic Complications in End-Stage Renal Disease Patients on Maintenance Hemodialysis</b> Open
Background: End-stage renal disease (ESRD) is a growing public health challenge in low- and middle-income countries, including Pakistan, where hemodialysis remains the predominant renal replacement therapy. Although lifesaving, hemodialysi…
View article: Assessing the Impact of Compliance and Health Literacy on the Management of Chronic Diseases in the City of Arar, KSA
Assessing the Impact of Compliance and Health Literacy on the Management of Chronic Diseases in the City of Arar, KSA Open
Objectives: Long-standing diseases are a major burden on patients, healthcare systems, and families throughout the world. Chronic diseases need prompt treatment to stop complications and improve outcomes. The purpose of this study is to kn…
View article: Molecular dynamics of inflammation resolution: therapeutic implications
Molecular dynamics of inflammation resolution: therapeutic implications Open
Inflammation is a critical part of innate immune response that is essential for exclusion of harmful stimuli and restoration of tissue homeostasis. Nonetheless, failure to resolve inflammation results in chronic inflammatory conditions, in…
View article: Prevalence and Management of Congenital Heart Diseases in Pakistan: A Comprehensive Cross-Sectional Study
Prevalence and Management of Congenital Heart Diseases in Pakistan: A Comprehensive Cross-Sectional Study Open
Background: Congenital heart diseases (CHDs) are among the most common birth anomalies globally, with higher prevalence and poorer outcomes in low- and middle-income countries due to delayed diagnosis, inadequate care infrastructure, and l…
View article: Neglected Tropical Diseases: Current Treatment Challenges and Future Therapeutic Potentials
Neglected Tropical Diseases: Current Treatment Challenges and Future Therapeutic Potentials Open
Neglected tropical diseases (NTDs) predominantly affect developing countries. Human African trypanosomiasis, leishmaniasis, Chagas disease, and malaria are protozoan infections that are endemic in developing countries and for which new dru…
View article: Phytochemical Profiling and Bioactivity of Celtis caucasica: Antioxidant, Antidiabetic, Anticholinesterase, and Anti-inflammatory Potential
Phytochemical Profiling and Bioactivity of Celtis caucasica: Antioxidant, Antidiabetic, Anticholinesterase, and Anti-inflammatory Potential Open
This study evaluates the phytochemical composition and biological activities of the ethanol extract of Celtis caucasica leaves. Gas Chromatography-Mass Spectrometry (GC-MS) identified sixteen bioactive compounds in the ethanol extract of C…
View article: The Assessment of Students’ Perception Regarding the Learning Experience in the Virtual Pharmacology Laboratory
The Assessment of Students’ Perception Regarding the Learning Experience in the Virtual Pharmacology Laboratory Open
Objective: The current study was conducted to evaluate students’ feedback on the virtual pharmacology classes among the second-year students in Faculty of Medicine, Northern Border University, Saudi Arabia. Materials and Methods: The study…
View article: FACTORS INFLUENCING PATIENT SATISFACTION WITH HEALTHCARE SERVICES OFFERED IN SELECTED PUBLIC-PRIVATE PARTNERSHIP HOSPITALS IN DISTRICT BAJAUR, PAKISTAN
FACTORS INFLUENCING PATIENT SATISFACTION WITH HEALTHCARE SERVICES OFFERED IN SELECTED PUBLIC-PRIVATE PARTNERSHIP HOSPITALS IN DISTRICT BAJAUR, PAKISTAN Open
Patient satisfaction can recognize certain parts of development in public sector healthcare systems. However, the quality-of-service delivery and the healthcare system in Pakistan are rarely evaluated from the standpoint of patient satisfa…
View article: An Insight Into the Phytochemical Composition, Cardioprotective, and Antioxidant Characteristics of Small Knotweed (<i>Polygonum plebeium</i> R. Br.) Extract and Its Derived Fractions
An Insight Into the Phytochemical Composition, Cardioprotective, and Antioxidant Characteristics of Small Knotweed (<i>Polygonum plebeium</i> R. Br.) Extract and Its Derived Fractions Open
Polygonum plebeium , a member of the Polygonaceae family, is commonly known as small knotweed and has been traditionally used to treat various ailments, including cough, gastrointestinal disorders, respiratory infections, liver disease, in…
View article: In vitro 5-LOX inhibitory and antioxidant potential of isoxazole derivatives
In vitro 5-LOX inhibitory and antioxidant potential of isoxazole derivatives Open
5-Lipoxygenase (5-LOX) is a key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes, leading to asthma. Developing potent 5-LOX inhibitors are highly attractive. In this research the previously synthesized isoxazole deriva…
View article: Pharmacological evaluation and binding behavior of 4,4′-diamino-2,2′-stilbene disulfonic acid with metal ions using spectroscopic techniques
Pharmacological evaluation and binding behavior of 4,4′-diamino-2,2′-stilbene disulfonic acid with metal ions using spectroscopic techniques Open
View article: Anti-Diabetic, Anti-Cholinesterase, and Anti-Inflammatory Potential of Plant Derived Extracts and Column Semi-Purified Fractions of Ficus benghalensis
Anti-Diabetic, Anti-Cholinesterase, and Anti-Inflammatory Potential of Plant Derived Extracts and Column Semi-Purified Fractions of Ficus benghalensis Open
Background: The present study aimed to investigate the in-vitro anti-diabetic, anti-cholinesterase, and anti-inflammatory potential of extracts from different parts of Ficus benghalensis, including leaves, stem, and roots, as well as isola…
View article: Evaluation of Habenaria aitchisonii Reichb. for antioxidant, anti-inflammatory, and antinociceptive effects with in vivo and in silico approaches
Evaluation of Habenaria aitchisonii Reichb. for antioxidant, anti-inflammatory, and antinociceptive effects with in vivo and in silico approaches Open
Habenaria aitchisonii Reichb was analyzed in this research, including its chemical composition and its in vitro antioxidant, anti-inflammatory, acute oral toxicity, and antinociceptive activity. The chloroform and ethyl acetate fractions w…
View article: Phenolic phytochemistry, in vitro, in silico, in vivo, and mechanistic anti-inflammatory and antioxidant evaluations of Habenaria digitata
Phenolic phytochemistry, in vitro, in silico, in vivo, and mechanistic anti-inflammatory and antioxidant evaluations of Habenaria digitata Open
Excessive and imbalance of free radicals within the body lead to inflammation. The objective of the current research work was to explore the anti-inflammatory and antioxidant potential of the isolated compounds from Habenaria digitata. In …
View article: Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies
Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies Open
Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized…
View article: Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth
Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth Open
The strong ethnopharmacological utilization of Isodon rugosus Wall. Ex. Benth is evident in the treatment of several types of pain and inflammation, including toothache, earache, abdominal pain, gastric pain, and generalized body pain and …
View article: Hypoglycemic, anti‐inflammatory, and neuroprotective potentials of crude methanolic extract from <i>Acacia nilotica</i> L. – results of an in vitro study
Hypoglycemic, anti‐inflammatory, and neuroprotective potentials of crude methanolic extract from <i>Acacia nilotica</i> L. – results of an in vitro study Open
Acacia nilotica L., also known as babul, belonging to the Fabaceae family and the Acacia genus, is typically used for ornamental purposes and also as a medicinal plant found in tropical and subtropical areas. This plant is a rich source of…
View article: Synthesis of Carbon Dots from Momordica Charantia fruit as a platform for Cadmium (II) sensing and antibacterial activity
Synthesis of Carbon Dots from Momordica Charantia fruit as a platform for Cadmium (II) sensing and antibacterial activity Open
Introduction: Carbon dots (CDs) are a new class of fluorescent nanomaterials thathave less the 10 nm particle size.The applications of CDs are drug delivery, synthetic chemistry, metal sensing, disease detection, and biosensing.Objective: …
View article: <i>IN VITRO</i>5-LOX INHIBITORY POTENTIAL AND ANTIOXIDANT ACTIVITY OF NEW ISOXAZOLE DERIVATIVES
<i>IN VITRO</i>5-LOX INHIBITORY POTENTIAL AND ANTIOXIDANT ACTIVITY OF NEW ISOXAZOLE DERIVATIVES Open
5-Lipoxygenase (5-LOX) is a key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes, leading to asthma. Developing potent 5-LOX inhibitors are highly attractive. In this research the previously synthesized isoxazole deriva…
View article: Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation
Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation Open
Monoamine oxidases (MAOs) inhibitors could decrease reactive oxygen species (ROS) generation, enhance mono-aminergic neural transmission, and have major therapeutic benefits for the treatment of Alzheimer's disease (AD).
View article: Assessment of Diverse Ber Cultivars Responds to Zinc Practices for Managing Nutrients
Assessment of Diverse Ber Cultivars Responds to Zinc Practices for Managing Nutrients Open
Ber is known as the King of Arid fruits and is rich in vitamin C, A, and B complexes.In this study, two years of experimentation with the four (04) cultivars of the Ber for morphological and biochemical attributes were evaluated.Different …