Abdullah Yahya Abdullah Alzahrani
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View article: Synthesis and in silico studies of new thiophene-isoquinolinone hybrids as potential larvicides against Culex pipiens
Synthesis and in silico studies of new thiophene-isoquinolinone hybrids as potential larvicides against Culex pipiens Open
View article: Defect‐driven innovations in photocatalysts: Pathways to enhanced photocatalytic applications
Defect‐driven innovations in photocatalysts: Pathways to enhanced photocatalytic applications Open
Defect engineering in photocatalytic materials has garnered significant interest due to the considerable impact of defects on light absorption, charge separation, and surface reaction dynamics. However, a limited understanding of how these…
View article: Design and synthesis of novel substituted <i>s</i>‐triazines tethered benzenesulfonamides as potential antimicrobial candidates: Antibiofilm and bacterial protein permeability assessments
Design and synthesis of novel substituted <i>s</i>‐triazines tethered benzenesulfonamides as potential antimicrobial candidates: Antibiofilm and bacterial protein permeability assessments Open
New s ‐triazine hydrazone hybrids ( 4a – 4r ) were designed and synthesized as promising microbial DNA gyrase inhibitors. This was done by taking the lead DNA gyrase inhibitor (AstraZeneca arylaminotriazine) as a reference. The novel sampl…
View article: Antihyperglycemic Hydantoin Derivative: Design, Molecular Docking, Synthesis, Crystal Structure, Computational Studies, Pharmacological and Toxicological Activities
Antihyperglycemic Hydantoin Derivative: Design, Molecular Docking, Synthesis, Crystal Structure, Computational Studies, Pharmacological and Toxicological Activities Open
View article: Targeted synthesis of a trimethoxyphenyltetrahydropyrimidine analogue designed as a DNA intercalator: <i>in silico</i> , multi-spectroscopic, thermodynamic, and <i>in vitro</i> approaches
Targeted synthesis of a trimethoxyphenyltetrahydropyrimidine analogue designed as a DNA intercalator: <i>in silico</i> , multi-spectroscopic, thermodynamic, and <i>in vitro</i> approaches Open
Based on the rational design of DNA intercalators and Topo-II inhibitors like doxorubicin (Dox) as a reference standard; methoxyphenyltetrahydropyrimidine a a trimethoxyphenyltetrahydropyrimidine analogue was designed as a DNA intercalator.
View article: Magnetically recoverable hybrid materials for electrochemical monitoring of hazardous contaminants: a review
Magnetically recoverable hybrid materials for electrochemical monitoring of hazardous contaminants: a review Open
The outcome of this review article highlights the role of iron oxide nanoparticles when integrated with a carbonaceous functional support for fabricating a nanocomposite electrode material.
View article: Crystal structure and Hirshfeld surface analysis of 3-phenyl-1-{3-[(3-phenylquinoxalin-2-yl)oxy]propyl}-1,2-dihydroquinoxalin-2-one
Crystal structure and Hirshfeld surface analysis of 3-phenyl-1-{3-[(3-phenylquinoxalin-2-yl)oxy]propyl}-1,2-dihydroquinoxalin-2-one Open
In the title compound, C 31 H 24 N 4 O 2 , the quinoxaline units are distinctly non-planar and twisted end-to-end. In the crystal, C—H...O and C—H...N hydrogen bonds link the molecules into chains extending along the a -axis direction. The…
View article: New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies
New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies Open
Diabetes is an emerging disorder in the world and is caused due to the imbalance of insulin production as well as serious effects on the body. In search of a better treatment for diabetes, we designed a novel class of 1,3,4-thiadiazole-bea…
View article: Synthesis, Characterization, Crystal Structure, Dft, Hsa, Admet Prediction and Antibacterial Activity of Thiohydantoin Analogues
Synthesis, Characterization, Crystal Structure, Dft, Hsa, Admet Prediction and Antibacterial Activity of Thiohydantoin Analogues Open
View article: Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors
Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors Open
Herein, we describe the design, synthesis and biological evaluation of a series of novel non-nucleotide sulfonylurea and sulfonylthiourea based small molecule inhibitors of h-ENPP1, h-ENPP3 and e5′NT. Among the tested compounds, 3b inhibit…
View article: Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators
Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators Open
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
View article: Hydrothermal-Assisted Synthesis of L-Cysteine Functionalized Zinc Oxide Micro-Rods: A Selective Adsorbent and an Efficient Electrochemical Sensor for Hg2+ Ion
Hydrothermal-Assisted Synthesis of L-Cysteine Functionalized Zinc Oxide Micro-Rods: A Selective Adsorbent and an Efficient Electrochemical Sensor for Hg2+ Ion Open
View article: 3-allyl-2-(allylthio)-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one: Synthesis, Spectroscopic characterization, Crystal structure, Computational investigations, Antibacterial activity and ADMET studies
3-allyl-2-(allylthio)-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one: Synthesis, Spectroscopic characterization, Crystal structure, Computational investigations, Antibacterial activity and ADMET studies Open
View article: Preparation, characterization and evaluation of hydrogels from different fractions of diverse medicinal plants for management of pain and inflammation
Preparation, characterization and evaluation of hydrogels from different fractions of diverse medicinal plants for management of pain and inflammation Open
Damage to body tissue either deeply or superficially causes pain sensation in response to which Inflammation occurs which is a normal protective natural response of the body to a variety of hostile agents. Different treatment options, incl…
View article: Mechanistic QSAR analysis to predict the binding affinity of diverse heterocycles as selective cannabinoid 2 receptor inhibitor
Mechanistic QSAR analysis to predict the binding affinity of diverse heterocycles as selective cannabinoid 2 receptor inhibitor Open
CB2R are fascinating targets for neuropathic pain and mood disorders because of their improved biological characteristics. Experimental data on 1296 cannabinoid-2 receptor inhibitors with different structural properties were used to develo…
View article: Correction to: Utilization of hydrolysate from saccharified sugarcane bagasse for phosphatases production
Correction to: Utilization of hydrolysate from saccharified sugarcane bagasse for phosphatases production Open
View article: Evaluation of structural, morphological, optical, and electrical properties of zinc oxide semiconductor nanoparticles with microwave plasma treatment for electronic device applications
Evaluation of structural, morphological, optical, and electrical properties of zinc oxide semiconductor nanoparticles with microwave plasma treatment for electronic device applications Open
ZnO is an important II-IV n-type direct bandgap semiconductor material that has exhibited wide consideration due to its applications in optoelectronic devices. In the present investigation, untreated and plasma-treated ZnO NPs were fabrica…
View article: Viscoelastic and Properties of Amphiphilic Chitin in Plasticised Polylactic Acid/Starch Biocomposite
Viscoelastic and Properties of Amphiphilic Chitin in Plasticised Polylactic Acid/Starch Biocomposite Open
The enhancement of the PLA thermomechanical properties is significant due to its suitability as a replacement for primary synthetic polymer use in diverse industrial production. The amphiphilic chitin was used as a compatibilizer in PLA/st…
View article: Regio- and stereoselectivity of the 1,3-dipolar cycloaddition of azomethine ylides to (E)-3-(2-oxo-2-(pyren-1-yl)ethylidene)indolin-2-ones: A combined experimental and theoretical study
Regio- and stereoselectivity of the 1,3-dipolar cycloaddition of azomethine ylides to (E)-3-(2-oxo-2-(pyren-1-yl)ethylidene)indolin-2-ones: A combined experimental and theoretical study Open
Functionalized oxindoles and pyrrolizidines form the central structural framework for numerous natural products with extensive biological and pharmacological applications. The requirement for high regio- and stereoselectivity is the main o…
View article: Multicomponent synthesis, cytotoxicity, and computational studies of novel imidazopyridazine-based N-phenylbenzamides
Multicomponent synthesis, cytotoxicity, and computational studies of novel imidazopyridazine-based N-phenylbenzamides Open
A one-pot multicomponent synthesis and application of new imidazopyridazine based N-phenylbenzamides is described. An atom-economical method involving dimethyl phthalate, substituted anilines, and pyridazine-4,5-diamine provided the desire…
View article: CuO NPs@Starch as a novel chemotherapeutic drug for the treatment of several types of gastrointestinal system cancers including gastric, pancreatic, and colon cancers
CuO NPs@Starch as a novel chemotherapeutic drug for the treatment of several types of gastrointestinal system cancers including gastric, pancreatic, and colon cancers Open
Copper oxide nanoparticles were successfully synthesized through a simple and ‘green’ route using starch as a capping and stabilizing agent under ultrasonic irradiation in alkaline medium. Unique reaction condition was prepared by ultrason…
View article: Ultrasound Assisted One Pot, Three-Component Reaction for Facile Design of Novel 1,2,3-Diazaphosphole, 1,5,2-Diazaphosphinine and 1,5,2-Diazaphosphepine Compounds Containing Coumarin Ring
Ultrasound Assisted One Pot, Three-Component Reaction for Facile Design of Novel 1,2,3-Diazaphosphole, 1,5,2-Diazaphosphinine and 1,5,2-Diazaphosphepine Compounds Containing Coumarin Ring Open
We have designed novel 1,2,3-diazaphosphole, 1,5,2-diazaphosphinine and 1,5,2-diazaphosphepine compounds containing a coumarin ring.The method depended on one-pot, three-component reaction of 3-(2-bromoacetyl)-2Hchromen-2-one (1) and dieth…
View article: Anti-COVID-19 activity of some benzofused 1,2,3-triazolesulfonamide hybrids using in silico and in vitro analyses
Anti-COVID-19 activity of some benzofused 1,2,3-triazolesulfonamide hybrids using in silico and in vitro analyses Open
View article: Synthesis and antimicrobial activity of 4-methylthiazole and 4-thiazolidinone derivatives derived from 5-(aryldiazo)salicylaldehyde thiosemicarbazones
Synthesis and antimicrobial activity of 4-methylthiazole and 4-thiazolidinone derivatives derived from 5-(aryldiazo)salicylaldehyde thiosemicarbazones Open
New series of thiazole derivatives were synthesized using 5-(aryldiazo)salicylaldehyde thiosemicarbazones 2a–i. Cyclocondensation of thiosemicarbazones 2a–i with chloroacetone afforded the corresponding 4-methylthiazole deriv…
View article: A Convenient Synthesis of Novel 6-Aryl-5-phenyl-5-oxido-6,7-dihydro[1,3,4,2]thiadiazaphospholo[5,4-c][1,2,4,5]triazaphosphinines
A Convenient Synthesis of Novel 6-Aryl-5-phenyl-5-oxido-6,7-dihydro[1,3,4,2]thiadiazaphospholo[5,4-c][1,2,4,5]triazaphosphinines Open
A convenient method for design of novel 6-aryl-5-phenyl-5-oxido-6,7dihydro [1,3,4,2]thiadiazaphospholo [5,4-c][1,2,4,5]triazaphosphinines was achieved.This method depended on three-component reaction of 5-hydrazino-1,3,4,2-thiadiazaphospho…
View article: Reversible addition fragmentation chain transfer (RAFT) of a new class of pH-sensitive monomers and polymerization induced self-assembly (PISA) in supercritical carbon dioxide
Reversible addition fragmentation chain transfer (RAFT) of a new class of pH-sensitive monomers and polymerization induced self-assembly (PISA) in supercritical carbon dioxide Open
Chapter 1 The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these monomeric precu…
View article: CCDC 1819144: Experimental Crystal Structure Determination
CCDC 1819144: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1819145: Experimental Crystal Structure Determination
CCDC 1819145: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis of <i>N</i>-[(dialkylamino)methyl]acrylamides and <i>N</i>-[(dialkylamino)methyl]methacrylamides from Schiff base salts: useful building blocks for smart polymers
Synthesis of <i>N</i>-[(dialkylamino)methyl]acrylamides and <i>N</i>-[(dialkylamino)methyl]methacrylamides from Schiff base salts: useful building blocks for smart polymers Open
Schiff base salts are characterized and form N-amino methylated acrylamides and methacrylamides.
View article: Efficient synthesis and RAFT polymerization of the previously elusive<i>N</i>-[(cycloalkylamino)methyl]acrylamide monomer class
Efficient synthesis and RAFT polymerization of the previously elusive<i>N</i>-[(cycloalkylamino)methyl]acrylamide monomer class Open
Schiff base salts allowed the multigram preparation of methylene amino substituted acrylamide monomers. These, as well as the hydrochloride salt intermediates, were subjected to controlled/living polymerizations for the first time. One-pot…