Anisur Rahman
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View article: Autoantibody origins in lupus and in relapse post CAR-T therapy
Autoantibody origins in lupus and in relapse post CAR-T therapy Open
Summary Anti-CD19 chimeric antigen receptor (CAR)-T therapy induces profound remissions in lupus by depleting B cells, challenging the longstanding view that treatment-resistant disease is sustained by long-lived plasma cells. Additionally…
View article: Practice of Writing Death Certificates in Different Medical College Hospitals of Bangladesh
Practice of Writing Death Certificates in Different Medical College Hospitals of Bangladesh Open
Background: Accurate death certification is essential for legal, administrative, and public health functions. However, errors in completing death certificates can undermine the reliability of mortality data. Objectives: This study aimed to…
View article: Towards a minimal core dataset for systemic lupus erythematosus studies
Towards a minimal core dataset for systemic lupus erythematosus studies Open
Objective SLE is a complex, heterogenous autoimmune disease. SLE researchers do not always collect the same data, making comparative studies difficult. We aimed to ascertain what variables SLE clinical researchers commonly collect for SLE …
View article: OP0271 DEVELOPMENT AND VALIDATION OF A EULAR DISEASE ACTIVITY SCORE IN ANTIPHOSPHOLIPID SYNDROME
OP0271 DEVELOPMENT AND VALIDATION OF A EULAR DISEASE ACTIVITY SCORE IN ANTIPHOSPHOLIPID SYNDROME Open
View article: INTERVAL-CENSORED OUTCOMES AND FLARE RISK AFTER HYDROXYCHLOROQUINE TAPERING/CESSATION: SENSITIVITY ANALYSES OF SYSTEMIC LUPUS INTERNATIONAL COLLABORATING CLINICS (SLICC) INCEPTION COHORT DATA
INTERVAL-CENSORED OUTCOMES AND FLARE RISK AFTER HYDROXYCHLOROQUINE TAPERING/CESSATION: SENSITIVITY ANALYSES OF SYSTEMIC LUPUS INTERNATIONAL COLLABORATING CLINICS (SLICC) INCEPTION COHORT DATA Open
O052 / #245 Topic: AS24 - SLE-Treatment ABSTRACT CONCURRENT SESSION 09: SLE THERAPY – REVISITING OLD DRUGS AND UNLOCKING HIDDEN POTENTIAL OF NEW MEDICATIONS 24-05-2025 10:40 AM - 11:40 AM Background/Purpose We previously evaluated hydroxyc…
View article: RHEUMATOLOGY DIAGNOSTICS UTILIZING ARTIFICIAL INTELLIGENCE FOR ANA PATTERN IDENTIFICATION AND TITRE QUANTIFICATION
RHEUMATOLOGY DIAGNOSTICS UTILIZING ARTIFICIAL INTELLIGENCE FOR ANA PATTERN IDENTIFICATION AND TITRE QUANTIFICATION Open
PT012 / #274 Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes POSTER TOUR 03: RECENT ADVANCEMENTS IN SLE CLINICAL OUTCOMES AND THERAPY 23-05-2025 10:00 AM - 10:40 AM Background/Purpose Antinuclear antibody (ANA) immunofluorescence (…
View article: DIRECT AND INDIRECT COSTS ASSOCIATED WITH DAMAGE ACCRUAL: RESULTS FROM THE SYSTEMIC LUPUS INTERNATIONAL COLLABORATING CLINICS (SLICC) INCEPTION COHORT
DIRECT AND INDIRECT COSTS ASSOCIATED WITH DAMAGE ACCRUAL: RESULTS FROM THE SYSTEMIC LUPUS INTERNATIONAL COLLABORATING CLINICS (SLICC) INCEPTION COHORT Open
O030 / #400 Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes ABSTRACT CONCURRENT SESSION 05: EMERGING INSIGHTS ON THE MANAGEMENT OF LUPUS MANIFESTATIONS AND COMORBIDITIES 23-05-2025 1:40 PM - 2:40 PM Background/Purpose We described …
View article: How Specific Signaling Pathways Like Wnt, Notch, and Hedgehog Regulate Cancer Stem Cells, and Potential Therapies Targeting These Pathways
How Specific Signaling Pathways Like Wnt, Notch, and Hedgehog Regulate Cancer Stem Cells, and Potential Therapies Targeting These Pathways Open
This study investigates the roles of Wnt, Notch, and Hedgehog signaling pathways in the regulation of cancer stem cells (CSCs) and evaluates the effects of their inhibition on CSC properties, including self-renewal, proliferation, and resi…
View article: Subclinical Atherosclerosis Risk Can Be Predicted in Female Patients With Systemic Lupus Erythematosus Using Metabolomic Signatures: An Observational Study
Subclinical Atherosclerosis Risk Can Be Predicted in Female Patients With Systemic Lupus Erythematosus Using Metabolomic Signatures: An Observational Study Open
Background Cardiovascular disease (CVD) is a leading cause of death in women with systemic lupus erythematosus (SLE) due to accelerated atherosclerosis that is not predicted by established CVD risk scores. This study aimed to develop, vali…
View article: The use of Local Vitamin D3 Gel in Immediate Dental Implants: A Randomized Controlled Study
The use of Local Vitamin D3 Gel in Immediate Dental Implants: A Randomized Controlled Study Open
View article: Paediatric Systemic Lupus Erythematosus with chronic diarrhea as an initial presentation
Paediatric Systemic Lupus Erythematosus with chronic diarrhea as an initial presentation Open
Lupus enteritis (LE) is a rare manifestation of Childhood Systemic lupus erythematosus (cSLE). The presentation is non-specific i.e loose motions, non-specific abdominal pain, nausea and vomiting. Presenting as a sole initial clinical find…
View article: Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies
Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies Open
Cleavage of β2GPI by plasmin results in the production of a unique S-shaped structural conformation and higher patient antibody binding. This novel structure may increase the production of antibodies and explain the loss of binding to phos…
View article: Domains for inclusion in a novel Treatment Response Measure for Systemic Lupus Erythematosus (TRM-SLE): results of a modified Delphi study
Domains for inclusion in a novel Treatment Response Measure for Systemic Lupus Erythematosus (TRM-SLE): results of a modified Delphi study Open
Objectives To achieve consensus on domains of active disease for inclusion in a novel outcome measure for SLE randomised controlled trials (RCTs), the Treatment Response Measure for SLE (TRM-SLE). Methods Domains nominated by TRM-SLE Taskf…
View article: Hemi-tongue ischemia due to antiphospholipid antibody syndrome- A case report
Hemi-tongue ischemia due to antiphospholipid antibody syndrome- A case report Open
Antiphospholipid antibody syndrome, also known as Hughes syndrome, is a multi-system autoimmune disorder characterized by recurrent thrombosis and fetal loss. The most common types of antiphospholipid antibodies include lupus anticoagulant…
View article: Risk of chronic kidney disease in 260 patients with lupus nephritis: analysis of a nationwide multicentre cohort with up to 35 years of follow-up
Risk of chronic kidney disease in 260 patients with lupus nephritis: analysis of a nationwide multicentre cohort with up to 35 years of follow-up Open
Objectives To compare proliferative (PLN) and membranous (MLN) lupus nephritis (LN) regarding clinical and laboratory presentation and long-term outcomes, and to investigate predictors of progression to chronic kidney disease (CKD). Method…
View article: Plasmin Cleavage of Beta-2-Glycoprotein I Alters its Structure and Ability to Bind to Pathogenic Antibodies
Plasmin Cleavage of Beta-2-Glycoprotein I Alters its Structure and Ability to Bind to Pathogenic Antibodies Open
Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome (APS) with antibodies leading to clinical manifestations. There are two known structural isomers of β2GPI, a J shape and a circular shaped one. The…
View article: Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus Open
BACKGROUND: Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia a…
View article: Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus Open
Background Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia an…
View article: P42 Management and clinical outcomes in 359 patients with SLE followed long-term in a specialist centre – Effect of sex, ethnicity and age at presentation
P42 Management and clinical outcomes in 359 patients with SLE followed long-term in a specialist centre – Effect of sex, ethnicity and age at presentation Open
Objective The Lupus Clinic at University College London Hospital (UCLH) has been recruiting patients since 1978.We carried out a comprehensive study of the records of patients from the clinic to study changes in management and outcomes in …
View article: P120 Unveiling CD4+ metabolic dysregulation in systemic lupus erythematosus: implications for targeting mitochondrial dysfunction
P120 Unveiling CD4+ metabolic dysregulation in systemic lupus erythematosus: implications for targeting mitochondrial dysfunction Open
Objective Systemic lupus erythematosus (SLE) is characterized by persistent stimulation of the adaptive immune response and oxidative stress from Reactive Oxygen Species (ROS) generation. Mitochondria, central to energy metabolism through …
View article: Lupus nephritis outcomes – is the picture changing?
Lupus nephritis outcomes – is the picture changing? Open
View article: P43 Management and clinical outcomes in 359 patients with SLE followed long-term in a specialist centre – changes over time
P43 Management and clinical outcomes in 359 patients with SLE followed long-term in a specialist centre – changes over time Open
Objective The Lupus Clinic at University College London Hospital (UCLH) has been recruiting patients since 1979.We carried out a comprehensive study of the records of patients from the clinic to study changes in management and outcomes dur…
View article: Antiphospholipid antibodies exacerbate damage following oxygen deprivation-reperfusion injury in an<i>in vivo</i>model for stroke and in<i>ex vivo</i>blood derived endothelial cells
Antiphospholipid antibodies exacerbate damage following oxygen deprivation-reperfusion injury in an<i>in vivo</i>model for stroke and in<i>ex vivo</i>blood derived endothelial cells Open
Background Prothrombotic antiphospholipid antibodies (aPL) found in patients with antiphospholipid syndrome (APS) are a recognised risk factor for ischemic stroke. However, it is unclear if aPL cause injury post thrombolysis leading to wor…
View article: Subclinical Atherosclerosis Risk Can Be Predicted in Females with Systemic Lupus Erythematosus (SLE) Using Metabolomic Signatures
Subclinical Atherosclerosis Risk Can Be Predicted in Females with Systemic Lupus Erythematosus (SLE) Using Metabolomic Signatures Open
View article: Preservation of whole antibodies within ancient teeth
Preservation of whole antibodies within ancient teeth Open
View article: Association Between Severe Nonadherence to Hydroxychloroquine and Systemic Lupus Erythematosus Flares, Damage, and Mortality in 660 Patients From the <scp>SLICC</scp> Inception Cohort
Association Between Severe Nonadherence to Hydroxychloroquine and Systemic Lupus Erythematosus Flares, Damage, and Mortality in 660 Patients From the <span>SLICC</span> Inception Cohort Open
Objective The goals of this study were to assess the associations of severe nonadherence to hydroxychloroquine (HCQ), objectively assessed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality r…
View article: LO-024 Association between severe non-adherence to hydroxychloroquine and SLE flares, damage, and mortality in 660 patients from the SLICC inception cohort
LO-024 Association between severe non-adherence to hydroxychloroquine and SLE flares, damage, and mortality in 660 patients from the SLICC inception cohort Open
Background Hydroxychloroquine is one of the major treatment of SLE, but its effectiveness is impaired by non-adherence, reported to range from 3% to 85% in SLE patients. Our objective was to assess the associations of severe non-adherence …
View article: LSO-083 ‘Systemic lupus erythematosus women with lupus nephritis in pregnancy therapeutic challenge (SWITCH)’: the systemic lupus international collaborating clinics experience
LSO-083 ‘Systemic lupus erythematosus women with lupus nephritis in pregnancy therapeutic challenge (SWITCH)’: the systemic lupus international collaborating clinics experience Open
Background Many SLE patients develop lupus nephritis (LN) and receive mycophenolate mofetil (MMF), a teratogenic drug. Guidelines recommend azathioprine (AZA) in SLE pregnancy without providing guidance on pharmacogenetic testing and thera…
View article: POS1499 FACTORS ASSOCIATED WITH CARDIOVASCULAR EVENTS IN SYSTEMIC LUPUS ERYTHEMATOSUS IN A MONOCENTRIC COHORT WITH UP TO 40 YEARS OF FOLLOW-UP
POS1499 FACTORS ASSOCIATED WITH CARDIOVASCULAR EVENTS IN SYSTEMIC LUPUS ERYTHEMATOSUS IN A MONOCENTRIC COHORT WITH UP TO 40 YEARS OF FOLLOW-UP Open
View article: POS0295 CD4+ T CELLS DEMONSTRATE METABOLIC REPROGRAMMING CHARACTERISED BY INCREASED REACTIVE OXYGEN SPECIES FORMATION AND ENHANCED ATP GENERATION IN SYSTEMIC LUPUS ERYTHEMATOSUS
POS0295 CD4+ T CELLS DEMONSTRATE METABOLIC REPROGRAMMING CHARACTERISED BY INCREASED REACTIVE OXYGEN SPECIES FORMATION AND ENHANCED ATP GENERATION IN SYSTEMIC LUPUS ERYTHEMATOSUS Open