Hiroki Abe
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View article: Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution
Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution Open
An accurate diagnostic method using biological indicators is critically needed for bipolar disorder (BD) and major depressive disorder (MDD). The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is…
View article: Edonerpic maleate enhances functional recovery from spinal cord injury with cortical reorganization in non-human primates
Edonerpic maleate enhances functional recovery from spinal cord injury with cortical reorganization in non-human primates Open
While spinal cord injury (SCI) aggravates the quality of life in humans by severe paralysis, clinical intervention to promote functional recovery from SCI is limited. We recently identified a small compound, edonerpic maleate (edonerpic MA…
View article: Systemic increase of AMPA receptors associated with cognitive impairment of long COVID
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID Open
Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targetin…
View article: Solitary Fibrous Tumor of the Stomach: Diagnostic Pitfalls and Clinical Implications
Solitary Fibrous Tumor of the Stomach: Diagnostic Pitfalls and Clinical Implications Open
This case highlights the difficulty in differentiating SFT from GIST preoperatively and underscores the importance of obtaining sufficient tissue samples to allow for immunohistochemical analysis, particularly STAT6 staining. Recognizing g…
View article: Edonerpic maleate prevents epileptic seizure during recovery from brain damage by balancing excitatory and inhibitory inputs
Edonerpic maleate prevents epileptic seizure during recovery from brain damage by balancing excitatory and inhibitory inputs Open
Functional recovery from brain damage, such as stroke, is a plastic process in the brain. The excitatory glutamate α -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) plays a crucial role in neuronal functions, and the …
View article: Anti‐epileptic drug use and subsequent degenerative dementia occurrence
Anti‐epileptic drug use and subsequent degenerative dementia occurrence Open
INTRODUCTION The use of anti‐epileptic drugs (AEDs) in degenerative dementia (DD) remains uncertain. We aimed to evaluate the association of early AED administration with subsequent DD occurrence. METHODS Using a large nationwide database,…
View article: Translational medicine of the glutamate AMPA receptor
Translational medicine of the glutamate AMPA receptor Open
Psychiatric and neurological disorders severely hamper patient's quality of life. Despite their high unmet needs, the development of diagnostics and therapeutics has only made slow progress. This is due to limited evidence on the biologica…
View article: A Case of Pancreatic Cancer that Recurred as Skin and Muscle Metastases
A Case of Pancreatic Cancer that Recurred as Skin and Muscle Metastases Open
49歳，女性．膵頭部癌の診断で亜全胃温存膵頭十二指腸切除術を施行．術後補助化学療法としてgemcitabine （GEM）投与を7サイクル実施．術後3年5カ月，左胸壁に疼痛を伴う30mm大の腫瘤が出現しFDG-PET/CTを施行したところ，右上腕皮下，右臀部・大腿皮下，左前腕筋肉内，左大腿筋肉内，左胸壁，左脊柱背側筋群内にFDGの集積を認め，膵癌皮膚転移および筋転移を疑われた．胸壁病変の切除生検の結果，膵癌の皮膚転移・筋転移と確定診断した．再度GEM単剤で治療を再開し，一時…
View article: A Case of Rectal Sigmoid Cancer with Anal Skin Metastasis
A Case of Rectal Sigmoid Cancer with Anal Skin Metastasis Open
症例は70歳男性．便柱の狭小化を主訴に前医を受診された．下部消化管内視鏡検査にて直腸に全周性腫瘍を指摘され，精査加療目的に当科紹介受診した．既往に9年前内痔核に対して痔核根治術を施行された．初診時に肛門縁の9時方向に1cm大の圧痛を伴わない硬結を認めた．直腸腫瘍と肛門部腫瘤の生検ではいずれもtub1の病理組織診断であった．精査の結果，直腸S状部（RS）癌cT4a cN2a cM1b（PLU2，SKI）cStageIVbの診断にてHartmann手術および経肛門的腫瘍切除術を…
View article: ANALYSIS OF RELATIONSHIP BETWEEN UTILIZATION CHARACTERISTICS AND HEAT ENVIRONMENT IN PARKS FOR HEALTH PROMOTION
ANALYSIS OF RELATIONSHIP BETWEEN UTILIZATION CHARACTERISTICS AND HEAT ENVIRONMENT IN PARKS FOR HEALTH PROMOTION Open
社会的変化としての高齢化による健康に配慮すべき人の増加や,地球的変化としての気候変動による暑熱環境の悪化する中で,健康維持,増進のために成人,高齢者が,安全にかつ,より積極的に都市空間に外出するための機会や場所の提供が求められる.本研究では,吹田市内に新設された健康増進を目的とした公園と摂津市内に新設された子どもの遊び場としての公園の利用実態を調査し,利用者属性や利用方法を比較し,健康増進型公園の特徴について考察した.また,健康増進型公園での実態調査に基づき,暑熱環境と運動…