Abedelmajeed Nasereddin
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View article: From stridor to symptom relief; management of pediatric Kommerell's diverticulum and vascular rings in Palestine [2016–2024]: a single center cohort study
From stridor to symptom relief; management of pediatric Kommerell's diverticulum and vascular rings in Palestine [2016–2024]: a single center cohort study Open
Background Kommerell's diverticulum (KD) with vascular rings is an uncommon cause of pediatric airway and feeding symptoms, and data from the Arab region are scarce. We report a Palestinian cohort of all diagnosed and managed cases, descri…
View article: Sleeve gastrectomy reveals the plasticity of the human gastric epithelium
Sleeve gastrectomy reveals the plasticity of the human gastric epithelium Open
Gastrin is secreted following a rise in gastric pH, leading to gastric acid secretion. Sleeve gastrectomy (SG), a bariatric surgery where 80% of the gastric corpus is excised, presents a challenge for gastric pH homeostasis. Using histolog…
View article: Sero‐Molecular Markers and Genetic Diversity of Hepatitis B Virus Isolated From Hemodialysis Patients From Jenin District, West Bank, Palestine
Sero‐Molecular Markers and Genetic Diversity of Hepatitis B Virus Isolated From Hemodialysis Patients From Jenin District, West Bank, Palestine Open
Background: Hepatitis B virus (HBV) infection remains a major global health challenge, especially among high‐risk groups such as hemodialysis (HD) patients. Aim: This study investigated the prevalence of sero‐molecular markers and the gene…
View article: Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis
Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis Open
Mammals withstand frequent and prolonged fasting periods due to hepatic production of glucose and ketone bodies. Because the fasting response is transcriptionally regulated, we asked whether enhancer dynamics impose a transcriptional progr…
View article: Use of the EmsB microsatellite-based next generation sequencing for genotyping of Echinococcus granulosus sensu lato in hydatid cyst tissue samples from animals and humans
Use of the EmsB microsatellite-based next generation sequencing for genotyping of Echinococcus granulosus sensu lato in hydatid cyst tissue samples from animals and humans Open
Echinococcus granulosus (Batsch, 1786), a cestode of the Teniidae family, causes human cystic echinococcosis (CE) also known as hydatid disease. Echinococcus granulosus sensu lato includes the G1, G3, G4, G5, G6/7 and G8/10 genotypes which…
View article: Epidemiological Characterization and Genetic Variation of the SARS-CoV-2 Delta Variant in Palestine
Epidemiological Characterization and Genetic Variation of the SARS-CoV-2 Delta Variant in Palestine Open
The emergence of new SARS-CoV-2 variants in Palestine highlights the need for continuous genetic surveillance and accurate screening strategies. This case series study aimed to investigate the geographic distribution and genetic variation …
View article: Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis
Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis Open
Mammals withstand frequent and prolonged fasting periods due to hepatic production of ketone bodies. Because the fasting response is transcriptionally-regulated, we asked whether enhancer dynamics impose a transcriptional program during re…
View article: Aldose reductase (−106) C/T gene polymorphism and associated risk factors with proliferative diabetic retinopathy in Palestine: A cross sectional study
Aldose reductase (−106) C/T gene polymorphism and associated risk factors with proliferative diabetic retinopathy in Palestine: A cross sectional study Open
Background and Aims Genetic variants play a crucial role in the development of diabetic retinopathy (DR). Therefore, our study aimed to investigate the relationship between aldose reductase ( ALR2 ) (C106T) polymorphism with proliferative …
View article: Association of IFNAR2 rs2236757 and OAS3 rs10735079 Polymorphisms with Susceptibility to COVID-19 Infection and Severity in Palestine
Association of IFNAR2 rs2236757 and OAS3 rs10735079 Polymorphisms with Susceptibility to COVID-19 Infection and Severity in Palestine Open
The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the potential correlation between the gene polymorphisms of the interferon receptor (IFNAR2) rs2236757 and oligoadenylate synthetase 3 (OAS3)…
View article: <scp>APOBEC3G</scp> protects the genome of human cultured cells and mice from radiation‐induced damage
<span>APOBEC3G</span> protects the genome of human cultured cells and mice from radiation‐induced damage Open
Cytosine deaminases AID/APOBEC proteins act as potent nucleic acid editors, playing important roles in innate and adaptive immunity. However, the mutagenic effects of some of these proteins compromise genomic integrity and may promote tumo…
View article: Failure to Detect Leishmania in the Blood of Patients with Old-World Cutaneous Leishmaniasis: Implications for Blood Donation
Failure to Detect Leishmania in the Blood of Patients with Old-World Cutaneous Leishmaniasis: Implications for Blood Donation Open
Cutaneous leishmaniasis (CL) is endemic in Israel, caused mainly by Leishmania major ( L. major ) and L. tropica . In addition, returning travelers import another leishmanial species such as L. braziliensis. Although we are dealing with a …
View article: Association of <i>IFNAR2</i> rs2236757 and <i>OAS3</i> rs10735079 polymorphisms with susceptibility to COVID-19 infection and severity
Association of <i>IFNAR2</i> rs2236757 and <i>OAS3</i> rs10735079 polymorphisms with susceptibility to COVID-19 infection and severity Open
The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the association of the interferon receptor ( IFNAR2 ) rs2236757 and oligoadenylate synthetase 3 ( OAS3 ) rs10735079 gene polymorphisms with r…
View article: Effectiveness of insecticide thermal fogging in hyrax dens in the control of leishmaniasis vectors in rural Palestine: A prospective study
Effectiveness of insecticide thermal fogging in hyrax dens in the control of leishmaniasis vectors in rural Palestine: A prospective study Open
Background Zoonotic cutaneous leishmaniasis (ZCL) is endemic in Palestine and transmitted by Phlebotomus sand flies. They inhabit dens of hyraxes, the reservoir animal. Control measures were implemented since 1996 but cases still occur. We…
View article: Concurrent molecular characterization of sand flies and Leishmania parasites by amplicon-based next-generation sequencing
Concurrent molecular characterization of sand flies and Leishmania parasites by amplicon-based next-generation sequencing Open
Background Phlebotomine sand flies are vectors of Leishmania parasites, which are the causative agents of leishmaniasis. Herein, we developed an amplicon-based next-generation sequencing (Amp-NGS) to characterize sand flies and Leishmania …
View article: Identification of SARS-CoV-2 Variants of Concern Using Amplicon Next-Generation Sequencing
Identification of SARS-CoV-2 Variants of Concern Using Amplicon Next-Generation Sequencing Open
The manuscript described SARS-Cov-2 genotyping by VOC-NGS, which presents an ideal balance of accuracy, rapidity, and cost for detecting and globally tracking VOCs and some VOI of SARS-CoV-2. A large number of clinical samples can be teste…
View article: Association of DNA methylation and genetic variations of the <i>APOE</i> gene with the risk of diabetic dyslipidemia
Association of DNA methylation and genetic variations of the <i>APOE</i> gene with the risk of diabetic dyslipidemia Open
Apolipoprotein E (APOE) is a key regulator of lipoprotein metabolism, and consequently, affects the plasma and tissue lipid contents. The aim of the present study was to investigate the parallel effects of APOE genetic variants and promote…
View article: Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients
Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients Open
Background Dyslipidemia in diabetes is common and characterized by hypertriglyceridemia with decreased levels of high‐density lipoprotein. The objective of this study was to assess the prevalence of MTHFR C677T polymorphism in Palestinian …
View article: Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones
Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones Open
Malaria is one of the most dangerous infectious diseases. Because the causative Plasmodium parasites have developed resistances against virtually all established antimalarial drugs, novel antiplasmodial agents are required. In order to tar…
View article: Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity Open
Acinar metaplasia is an initial step in a series of events that can lead to pancreatic cancer. Here we perform single-cell RNA-sequencing of mouse pancreas during the progression from preinvasive stages to tumor formation. Using a reporter…
View article: Case Report: Autochthonous Case of Human Visceral Leishmaniasis in the West Bank, Palestine
Case Report: Autochthonous Case of Human Visceral Leishmaniasis in the West Bank, Palestine Open
Human visceral leishmaniasis (HVL) is a parasitic disease infecting children in the Mediterranean region. Here, we portray a case of a 2-year-old child with an epidemiological description of the situation surrounding the case. The patient …
View article: CCDC 1526841: Experimental Crystal Structure Determination
CCDC 1526841: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Global genome diversity of the Leishmania donovani complex
Global genome diversity of the Leishmania donovani complex Open
Protozoan parasites of the Leishmania donovani complex – L. donovani and L. infantum – cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representi…