Abeer Alharbi
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View article: Enhancing Primary Healthcare Infrastructure under Vision 2030: Strategic Development of Medical Clinics in Saudi Arabia
Enhancing Primary Healthcare Infrastructure under Vision 2030: Strategic Development of Medical Clinics in Saudi Arabia Open
Saudi Arabia’s Vision 2030 has prioritized healthcare transformation through the expansion and modernization of primary healthcare clinics (PHCs) to ensure equitable access, high-quality services, and patient-centered care. This review exp…
View article: Outcomes of Levofloxacin-Based Regimens in Adults With Severe Community-Acquired Pneumonia Requiring ICU Admission: A Single-Center Retrospective Cohort From Jazan, Saudi Arabia
Outcomes of Levofloxacin-Based Regimens in Adults With Severe Community-Acquired Pneumonia Requiring ICU Admission: A Single-Center Retrospective Cohort From Jazan, Saudi Arabia Open
Background Levofloxacin is widely used in combination regimens for severe community-acquired pneumonia (CAP) in the ICU; however, real-world outcome data from resource-limited settings remain scarce. Objective: To evaluate 28-day mortality…
View article: Advances in Dental Care: Emerging Technologies, Patient Safety, and Quality Outcomes
Advances in Dental Care: Emerging Technologies, Patient Safety, and Quality Outcomes Open
Lifelong learning through CE also addresses emerging societal needs in dentistry. Topics such as sustainability, digital ethics, and patient safety culture are increasingly featured in CE curricula. Addressing these issues ensures that den…
View article: Eyelid Amyloidosis: A Rare Condition With Diagnostic Challenges
Eyelid Amyloidosis: A Rare Condition With Diagnostic Challenges Open
We present a rare and challenging case of a man who presented with mild mechanical ptosis and inferior dystopia, diagnosed with eyelid amyloidosis. A 40-year-old healthy man presented with a painless mass on his left upper eyelid that star…
View article: Fear of Falling After Total Knee Replacement: A Saudi Experience
Fear of Falling After Total Knee Replacement: A Saudi Experience Open
Background: Fear of falling (FOF) is a significant concern among older adults, especially after total knee arthroplasty (TKA). FOF can limit daily activities, reduce quality of life, and hinder recovery. This study aimed to investigate the…
View article: TPC2 in drug development: Emerging target for cancer, viral infections, cardiovascular diseases, and neurological disorders
TPC2 in drug development: Emerging target for cancer, viral infections, cardiovascular diseases, and neurological disorders Open
The lysosomal two-pore channel 2 (TPC2) modulates intracellular calcium (Ca2 +) signaling and has been implicated in inflammatory, cardiovascular, and neurodegenerative conditions, as well as cancer and viral infections. Despite…
View article: Behavioral Counseling to Promote a Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Cardiovascular Disease Risk Factors: Updated Systematic Review for the U.S. Preventive Services Task Force [Internet]
Behavioral Counseling to Promote a Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Cardiovascular Disease Risk Factors: Updated Systematic Review for the U.S. Preventive Services Task Force [Internet] Open
Background: A healthy diet is characterized by a balanced and varied selection of meals and drinks that aids a person in attaining and sustaining a healthy weight. Aim: To carefully assess the proof regarding the harm and benefits of behav…
View article: Advances in Dental Care: Emerging Technologies, Patient Safety, and Quality Outcomes
Advances in Dental Care: Emerging Technologies, Patient Safety, and Quality Outcomes Open
Lifelong learning through CE also addresses emerging societal needs in dentistry. Topics such as sustainability, digital ethics, and patient safety culture are increasingly featured in CE curricula. Addressing these issues ensures that den…
View article: Ecthyma amidst the global monkeypox outbreak: A key differential? —A case series
Ecthyma amidst the global monkeypox outbreak: A key differential? —A case series Open
View article: Comparing tele-pharmacy and standard clinic follow-up for newly initiated warfarin anticoagulation therapy
Comparing tele-pharmacy and standard clinic follow-up for newly initiated warfarin anticoagulation therapy Open
This study demonstrates that patients who receive warfarin for the first time at an anticoagulation clinic can use the telepharmacy method without the fear undesirable outcomes. Results of this study support the continued use and expansion…
View article: Outcome of Pediatric Patients With Sickle Cell Anemia Admitted With Fever: A Retrospective Single-Center Study
Outcome of Pediatric Patients With Sickle Cell Anemia Admitted With Fever: A Retrospective Single-Center Study Open
View article: The Clinical Manifestations, Risk Factors, Etiologies, and Outcomes of Adult Patients with Infectious Meningitis and Encephalitis: Single Center Experience
The Clinical Manifestations, Risk Factors, Etiologies, and Outcomes of Adult Patients with Infectious Meningitis and Encephalitis: Single Center Experience Open
(1) Background: Central nervous system (CNS) infections, including meningitis and encephalitis, are serious conditions which are associated with high morbidity and mortality. This study aims to identify the clinical manifestations, etiolog…
View article: Response to prone positioning in COVID-19 patients with acute respiratory distress syndrome: a retrospective observational study
Response to prone positioning in COVID-19 patients with acute respiratory distress syndrome: a retrospective observational study Open
Background COVID-19 pneumonia and respiratory failure are the leading causes of death in COVID-19 patients. Prone positioning was hypothesized to improve oxygenation in ARDS patients and is being studied in COVID-19, but the current eviden…
View article: The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank
The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank Open
View article: Detection of Cytological Alterations in Oral Mucosa among Female Cigarette Smokers
Detection of Cytological Alterations in Oral Mucosa among Female Cigarette Smokers Open
View article: CYP2C19 Phenotype and Body Weight-Guided Voriconazole Initial Dose in Infants and Children after Hematopoietic Cell Transplantation
CYP2C19 Phenotype and Body Weight-Guided Voriconazole Initial Dose in Infants and Children after Hematopoietic Cell Transplantation Open
Prophylactic voriconazole use is recommended for children undergoing hematopoietic cell transplantation (HCT). Dosing considerations are essential, due to the narrow therapeutic window of voriconazole.
View article: Deciphering the Role of Endolysosomal Ca2+ Channels in Immunity
Deciphering the Role of Endolysosomal Ca2+ Channels in Immunity Open
The role of endolysosomal Ca 2+ signalling in immunity has been a subject of increasing interest in recent years. Here, we discuss evolving knowledge relating to the contribution of endolysosomal Ca 2+ channels that include TPCs, TRPMLs, a…
View article: CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant
CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant Open
Fungal CYP51A (14α-sterol demethylase) is the target of an azole antifungal, voriconazole (VCZ), which also partially inhibits human CYP51A1. Hepatotoxicity is a common adverse effect of azoles, which is reported to be caused…
View article: Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside
Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside Open
Metastatic cancer is one of the major causes of cancer-related mortalities. Metastasis is a complex, multi-process phenomenon, and a hallmark of cancer. Calcium (Ca2+) is a ubiquitous secondary messenger, and it has become evident that Ca2…
View article: Clinical pharmacology applications in clinical drug development and clinical care: A focus on Saudi Arabia
Clinical pharmacology applications in clinical drug development and clinical care: A focus on Saudi Arabia Open
View article: Ceftobiprole for Treatment of MRSA Blood Stream Infection: A Case Series
Ceftobiprole for Treatment of MRSA Blood Stream Infection: A Case Series Open
Ebrahim Mahmoud,1 Sarah Al Mansour,1 Mohammad Bosaeed,1– 3 Ahmad Alharbi,1 Abdulrahman Alsaedy,1,2 Sameera Aljohani,2,4 Bassam Alalwan,4 Adel Alothman1,2, † 1Division of Infectious Diseases, Department of Medicine, King Abdulaziz Medical C…
View article: Targeting Two-Pore Channels: Current Progress and Future Challenges
Targeting Two-Pore Channels: Current Progress and Future Challenges Open
View article: Assessing Adherence to Inhaled Corticosteroids Among Adults with Asthma in Kuwait Using the Medication Adherence Report Scale for Asthma
Assessing Adherence to Inhaled Corticosteroids Among Adults with Asthma in Kuwait Using the Medication Adherence Report Scale for Asthma Open
Abdullah Albassam,1 Amal Alharbi,2 Ahmed Awaisu3 1Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, Kuwait City, Kuwait; 2Department of Pharmacy, Farwaniya Hospital, Ministry of Health, Kuwait City, Kuwait; 3Departme…
View article: Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis
Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis Open
Ca2+ homeostasis is dysregulated in cancer cells and affects processes such as tumorigenesis, angiogenesis, autophagy, progression, and metastasis. Emerging evidence has suggested that endolysosomal cation channels sustain sever…