Mohamed J. Saadh
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View article: Designing of multi-epitope vaccine against Varicella zoster virus (VZV) using immunoinformatics and structural analysis: In silico study
Designing of multi-epitope vaccine against Varicella zoster virus (VZV) using immunoinformatics and structural analysis: In silico study Open
Introduction: The Varicella-zoster virus (VZV) causes varicella (chickenpox) and herpes zoster (shingles), posing significant global health challenges. Despite existing vaccines, gaps in coverage and efficacy persist, necessitating novel v…
View article: Ferroptosis and non-coding RNAs in breast cancer: insights into CAF and TAM interactions
Ferroptosis and non-coding RNAs in breast cancer: insights into CAF and TAM interactions Open
Ferroptosis, a form of regulated cell death characterized by the accumulation of lipid peroxides, has emerged as a crucial player in cancer biology, particularly in breast cancer. This review article explores the intricate regulation of fe…
View article: Fabricating a Zn-doped nanocone scaffold as a potential carrier for the drug delivery of propylthiouracil
Fabricating a Zn-doped nanocone scaffold as a potential carrier for the drug delivery of propylthiouracil Open
A representative zinc (Zn)-doped nanocone (ZCON) scaffold was fabricated as a potential carrier for the drug delivery of propylthiouracil (PTU) along with density functional theory (DFT) calculations. Interactions of PTU and ZCON substance…
View article: Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis Open
View article: Gut instinct: harnessing the power of probiotics to tame pathogenic signaling pathways in ulcerative colitis
Gut instinct: harnessing the power of probiotics to tame pathogenic signaling pathways in ulcerative colitis Open
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) marked by persistent inflammation of the mucosal lining of the large intestine, leading to debilitating symptoms and reduced quality of life. Emerging evidence suggests …
View article: Retraction Note: Synthesis and characterization of ZrFe2O4@SiO2@Ade-Pd as a novel, recyclable, green, and versatile catalyst for Buchwald–Hartwig and Suzuki–Miyaura cross-coupling reactions
Retraction Note: Synthesis and characterization of ZrFe2O4@SiO2@Ade-Pd as a novel, recyclable, green, and versatile catalyst for Buchwald–Hartwig and Suzuki–Miyaura cross-coupling reactions Open
View article: Author Correction: Synthesis and characterization of ZrFe2O4@SiO2@Ade-Pd as a novel, recyclable, green, and versatile catalyst for Buchwald–Hartwig and Suzuki–Miyaura cross-coupling reactions
Author Correction: Synthesis and characterization of ZrFe2O4@SiO2@Ade-Pd as a novel, recyclable, green, and versatile catalyst for Buchwald–Hartwig and Suzuki–Miyaura cross-coupling reactions Open
View article: Biological activity comparison between ciprofloxacin loaded to silica nanoparticles and silver nanoparticles for the inhibition of Brucella melitensis
Biological activity comparison between ciprofloxacin loaded to silica nanoparticles and silver nanoparticles for the inhibition of Brucella melitensis Open
Background and Aim: Brucella melitensis is responsible for brucellosis, a highly contagious, life-threatening disease that has a high impact in low- and middle-income countries. This study aimed to compare silica nanoparticles (SiO-NPs) lo…
View article: EVALUATION OF THE POTENTIAL CYTOTOXICITY OF RUTHENIUM COMPLEX II AGAINST U-373 GLIOBLASTOMA CELLS
EVALUATION OF THE POTENTIAL CYTOTOXICITY OF RUTHENIUM COMPLEX II AGAINST U-373 GLIOBLASTOMA CELLS Open
Objective: The potential of ruthenium complexes as anticancer agents has gained significant attention in the scientific community. The aim of this study was to investigate the effect of dithiocyanato-N-bis[8(diphenylphosphino)quinoline]rut…
View article: SILVER NANOPARTICLES INHIBIT INFECTIOUS BRONCHITIS VIRUS REPLICATION
SILVER NANOPARTICLES INHIBIT INFECTIOUS BRONCHITIS VIRUS REPLICATION Open
Objective: Avian infectious bronchitis virus (IBV) threatens the poultry industry and causes global economic losses. The IBV is highly variable. Thus, no effective drugs are available. Objective of the present study was to evaluate silver …
View article: Assessments of carbon and boron nitride graphdiyne nanosheets for exploring the amphetamine drug adsorbents/sensors along with density functional theory
Assessments of carbon and boron nitride graphdiyne nanosheets for exploring the amphetamine drug adsorbents/sensors along with density functional theory Open
By the importance of developing detection materials and devices, the current work was done to provide molecular insights into the exploration of amphetamine (AMP) adsorbents/sensors through the density functional theory (DFT) assessments o…
View article: Computational assessments of sumanene-hydroxyurea conjugations for proposing a novel drug design and delivery platform
Computational assessments of sumanene-hydroxyurea conjugations for proposing a novel drug design and delivery platform Open
Sumanene-hydroxyurea (SUM-HYD) conjugations were assessed based on the density functional theory (DFT) computational assessments for proposing a novel drug design and delivery platform. The structural geometry optimizations and electronic …
View article: Antiproliferative activity of ruthenium complex II against human cancer cell in vitro
Antiproliferative activity of ruthenium complex II against human cancer cell in vitro Open
Despite significant advancements in cancer treatment, there is a constant need for new and effective therapeutic options. One such potential weapon in the fight against cancer is ruthenium complex II. In this article, we synthesized, chara…
View article: Anticancer and antiproliferative activity of ruthenium complex (II) bearing 3,3’-dicarboxy-2,2’-bipyridine ligand
Anticancer and antiproliferative activity of ruthenium complex (II) bearing 3,3’-dicarboxy-2,2’-bipyridine ligand Open
Even though significant progress has been made in cancer treatment, there is always room for improvement. The experimental drug Ruthenium Complex II shows promise as a cancer treatment. In this article, the dichloro-3,3’-dicarboxy-2,2’-bip…
View article: RETRACTED ARTICLE: Synthesis and characterization of ZrFe2O4@SiO2@Ade-Pd as a novel, recyclable, green, and versatile catalyst for Buchwald–Hartwig and Suzuki–Miyaura cross-coupling reactions
RETRACTED ARTICLE: Synthesis and characterization of ZrFe2O4@SiO2@Ade-Pd as a novel, recyclable, green, and versatile catalyst for Buchwald–Hartwig and Suzuki–Miyaura cross-coupling reactions Open
View article: The effect of polymeric films of hydroxypropyl methylcellulose (<scp>HPMC)</scp>/chitosan on ofloxacin release, diffusion, and biological activity
The effect of polymeric films of hydroxypropyl methylcellulose (<span>HPMC)</span>/chitosan on ofloxacin release, diffusion, and biological activity Open
Infectious diseases caused by resistant bacteria have been investigated by several researchers recently. Ofloxacin is a quinolone antibiotic used against resistant microorganisms and in different routes of administration. Transdermal drug …
View article: Green synthesis of silver nanoparticles using Piper betle exhibit high antimicrobial activity against Salmonella enteritidis and E. coli
Green synthesis of silver nanoparticles using Piper betle exhibit high antimicrobial activity against Salmonella enteritidis and E. coli Open
Piper betle (P. betle) is a popular medicinal plant in Asia. Plant leaves have been used as a traditional medicine to treat various health conditions. P. betle leaf has plentiful antimicrobial products. The extraction of leaves from P. bet…
View article: Synthesis, characterization and antibacterial activity of ruthenium complex bearing 3,3’-dicarboxy-2,2’-bipyridine ligand
Synthesis, characterization and antibacterial activity of ruthenium complex bearing 3,3’-dicarboxy-2,2’-bipyridine ligand Open
The development of bacteria has been one of the most significant advances in medical science. The need for the development of novel antibacterial is clear, but the development of new antibacterial classes is more important. In this study, …
View article: Exploring Impacts of Oil and Water Environments on Structural and Electronic Features of Vitamin B3 along with DFT Calculations
Exploring Impacts of Oil and Water Environments on Structural and Electronic Features of Vitamin B3 along with DFT Calculations Open
Density functional theory (DFT) calculations were performed to investigate the features of vitamin B3 (Vit-B3) in oil and water environments. Two up and down structural conformations were found based on the orientation of hydrogen atom of …
View article: Progress and prospects on vaccine development against monkeypox infection
Progress and prospects on vaccine development against monkeypox infection Open
View article: Exosomal non-coding RNAs’ role in immune regulation and potential therapeutic applications
Exosomal non-coding RNAs’ role in immune regulation and potential therapeutic applications Open
Exosomes are now significant players in both healthy and unhealthy cell-to-cell communication. Exosomes can mediate immune activation or immunosuppression, which can influence the growth of tumors. Exosomes affect the immune responses to m…
View article: Use of IOT-Based Aquaculture Equipment in India
Use of IOT-Based Aquaculture Equipment in India Open
Aquaculture has been considered to be the backward area within applied science and so the application of the IoT will be fruitful in making an accurate increase in the facilities. As a result, it's important to use technologies to help ide…
View article: RETRACTED: A Mendelian Randomization Analysis Investigates Causal Associations between Inflammatory Bowel Diseases and Variable Risk Factors
RETRACTED: A Mendelian Randomization Analysis Investigates Causal Associations between Inflammatory Bowel Diseases and Variable Risk Factors Open
The question of whether variable risk factors and various nutrients are causally related to inflammatory bowel diseases (IBDs) has remained unanswered so far. Thus, this study investigated whether genetically predicted risk factors and nut…
View article: Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity
Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity Open
Background and Aim: Exposure to pesticide mixtures used in agricultural practice poses a grave risk to non-target animals. This study aimed to determine whether red grape seed extract (RGSE, which is 95% bioflavonoids and equal to 12,000 m…
View article: A DFT study on effective detection of ClCN gas by functionalized, decorated, and doped nanocone strategies
A DFT study on effective detection of ClCN gas by functionalized, decorated, and doped nanocone strategies Open
Density Functional Theory (DFT) was employed to investigate the interaction between cyanogen chloride (ClCN) and the surface of a carbon nanocone (CNC).
View article: Extraction of some essential amino acids using aqueous two-phase systems made by sugar-based deep eutectic solvents
Extraction of some essential amino acids using aqueous two-phase systems made by sugar-based deep eutectic solvents Open
Aqueous two-phase systems (ATPSs) have long been recognized as versatile and efficient tools for the extraction of biomolecules, including amino acids.
View article: The Impressive Evaluation of Selenium Yeast Role Against Diabetes Mellitus and its Comorbidities by Streptozotocin-Induced Diabetes in Rats
The Impressive Evaluation of Selenium Yeast Role Against Diabetes Mellitus and its Comorbidities by Streptozotocin-Induced Diabetes in Rats Open
Current anti-diabetic drugs exhibit many side-effects and alternative strategies with minimal side effects and low cost are greatly needed.This study aimed to evaluate selenium yeast (SY) role against diabetes mellitus (DM) in Streptozotoc…
View article: The Status of Carbapenem Resistance in Cystic Fibrosis: A Systematic Review and Meta-Analysis.
The Status of Carbapenem Resistance in Cystic Fibrosis: A Systematic Review and Meta-Analysis. Open
Background: Antibiotic resistance in cystic fibrosis (CF) is a well-known phenomenon. However, the comprehensive epidemiological impact of antibiotic resistance in CF is not clearly documented. So, this meta-analysis evaluated the p…
View article: SARS-COV-2 3CL-PROTEASE INHIBITORS AS ANTIVIRAL AGENT AGAINST COVID-19
SARS-COV-2 3CL-PROTEASE INHIBITORS AS ANTIVIRAL AGENT AGAINST COVID-19 Open
The SARS-CoV-2 virus causes coronavirus, and the pandemic has led to efforts to develop appropriate drugs for treatment. Understanding the structure and function of SARS-CoV-2 3CL is crucial in unlocking ways of developing effective drugs.…
View article: Efficacy of COVID-19 vaccines
Efficacy of COVID-19 vaccines Open