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View article: The Pubovesical Complex–Sparing Laparoscopic Radical Prostatectomy Improves Early Urinary Continence Without Compromising Oncologic Safety: A Prospective, Randomized, and Double‐Blinded Clinical Trial
The Pubovesical Complex–Sparing Laparoscopic Radical Prostatectomy Improves Early Urinary Continence Without Compromising Oncologic Safety: A Prospective, Randomized, and Double‐Blinded Clinical Trial Open
Background Post‐prostatectomy urinary incontinence significantly impacts quality of life. Techniques that preserve periprostatic structures have shown promise in promoting earlier continence recovery, particularly with robotic‐assisted sur…
View article: Prospective Validation of an Automated Hybrid Multidimensional MRI Tool for Prostate Cancer Detection Using Targeted Biopsy: Comparison with PI-RADS-based Assessment
Prospective Validation of an Automated Hybrid Multidimensional MRI Tool for Prostate Cancer Detection Using Targeted Biopsy: Comparison with PI-RADS-based Assessment Open
This study demonstrates that hybrid multidimensional MRI has the potential to improve MRI/US fusion biopsy results, provide more reliable detection of prostate cancer, and add complementary information to Prostate Imaging and Reporting Dat…
View article: Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway Open
The decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. We discovered that human p11 is a critica…
View article: Acute kidney injury after allogeneic hematopoietic stem cell transplantation – Predictors and survival impact: A single center retrospective study
Acute kidney injury after allogeneic hematopoietic stem cell transplantation – Predictors and survival impact: A single center retrospective study Open
Patients submitted to HSCT are at an increased risk for AKI, which etiology is often multifactorial. Due to AKI incidence, specialized nephrologist consultation as part of the multidisciplinary team might be of benefit.
View article: Allogeneic stem cell transplant in relapsed/ refractory Hodgkin lymphoma: A 21 years’ experience
Allogeneic stem cell transplant in relapsed/ refractory Hodgkin lymphoma: A 21 years’ experience Open
Background: Allogenic stem cell transplant (alloSCT) has been used for several decades as a salvage strategy for relapsed/ refractory Hodgkin lymphoma (R/R HL), being a durable disease control method for some patients. Methods: A unicenter…
View article: MAVS Expression in Alveolar Macrophages Is Essential for Host Resistance against <i>Aspergillus fumigatus</i>
MAVS Expression in Alveolar Macrophages Is Essential for Host Resistance against <i>Aspergillus fumigatus</i> Open
Our recent data demonstrate a critical role of the RIG-I–like receptor family in regulating antifungal immunity against Aspergillus fumigatus in a murine model. However, the importance of this pathway in humans and the cell types that use …
View article: P1336: ANTIVIRAL EXPOSURE TO GANCICLOVIR AND VALGANCICLOVIR IS NOT ASSOCIATED WITH INCREASED INCIDENCE OF RELAPSE OR SECONDARY MALIGNANCIES IN HEMATOPOIETIC STEM CELL TRANSPLANTATION RECIPIENTS
P1336: ANTIVIRAL EXPOSURE TO GANCICLOVIR AND VALGANCICLOVIR IS NOT ASSOCIATED WITH INCREASED INCIDENCE OF RELAPSE OR SECONDARY MALIGNANCIES IN HEMATOPOIETIC STEM CELL TRANSPLANTATION RECIPIENTS Open
Background: Hematopoietic stem cell (HSC) transplantation (HSCT) is used in the treatment of hematologic malignancies, bone marrow failure and immunodeficiencies and is often associated with cytomegalovirus (CMV) reactivation/infection. Ga…
View article: P1373: TACKLING IMMUNOLOGICAL FINDINGS AS SURROGATE MARKERS OF HISTOLOGICAL SEVERITY AND RESPONSE TO THERAPY IN ACUTE GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE
P1373: TACKLING IMMUNOLOGICAL FINDINGS AS SURROGATE MARKERS OF HISTOLOGICAL SEVERITY AND RESPONSE TO THERAPY IN ACUTE GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE Open
Background: Acute digestive tract graft-versus-host disease (GI-GVHD) is a potential complication for patients receiving allogeneic hematopoietic stem cell transplants (HSCT). The disease burden and response to therapy rely on a dynamic sy…
View article: P1383: EXTRAMEDULLARY RELAPSE OF ACUTE MYELOID LEUKEMIA AND ACUTE LYMPHOBLASTIC LEUKEMIA AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION - A SINGLE-CENTER EXPERIENCE
P1383: EXTRAMEDULLARY RELAPSE OF ACUTE MYELOID LEUKEMIA AND ACUTE LYMPHOBLASTIC LEUKEMIA AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION - A SINGLE-CENTER EXPERIENCE Open
Background: Acute leukemia relapse after allogeneic hematopoietic cell transplant (allo-HCT) is challenging. Allo-HCT is a potentially curative treatment for acute myeloid leukemia (AML) and Acute lymphoblastic leukemia (ALL). Extramedulla…
View article: PB2177: ANTITHYMOCYTE GLOBULIN AS TREATMENT OF ACUTE GRAFT VERSUS HOST DISEASE - 10 YEARS OF EXPERIENCE AT A SINGLE-CENTER
PB2177: ANTITHYMOCYTE GLOBULIN AS TREATMENT OF ACUTE GRAFT VERSUS HOST DISEASE - 10 YEARS OF EXPERIENCE AT A SINGLE-CENTER Open
Background: Acute graft versus host disease (aGVHD) is the leading cause of morbidity and non-relapse mortality, following allogeneic hematopoietic stem cell transplant (AHSCT). It affects particularly the skin, liver, and gastrointestinal…
View article: Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen
Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen Open
Summary The analysis of host-pathogen interactions bears the potential to discover novel pathogenicity mechanisms and to obtain novel insights into basic mechanisms of cell biology. Here, we obtained unprecedented insight into both. We dis…
View article: Acute kidney injury after allogeneic hematopoietic stem cell transplantation – Predictors and survival impact: A single center retrospective study
Acute kidney injury after allogeneic hematopoietic stem cell transplantation – Predictors and survival impact: A single center retrospective study Open
Introduction and objectives: Acute kidney injury (AKI) is a frequent complication of hematopoietic stem cell transplantation (HSCT) and appears to be linked to increased morbidity and mortality. The aim of this study was to evaluate the in…
View article: MAVS expression in alveolar macrophages is essential for host resistance against <i>Aspergillus fumigatus</i>
MAVS expression in alveolar macrophages is essential for host resistance against <i>Aspergillus fumigatus</i> Open
Our recent data demonstrates a critical role of the RIG-I-like receptor (RLR) family in regulating antifungal immunity against Aspergillus fumigatus in a murine model. However, the importance of this pathway in humans and the cell type(s) …
View article: Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis
Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis Open
The fungal pathogen Aspergillus fumigatus can cause severe and life-threatening forms of infection in immunocompromised patients. Activation of glycolysis is essential for innate immune cells to mount effective antifungal responses.
View article: Haplo‐identical or mismatched unrelated donor hematopoietic cell transplantation for <scp>Fanconi</scp> anemia: Results from the <scp>Severe Aplastic Anemia Working Party</scp> of the <scp>EBMT</scp>
Haplo‐identical or mismatched unrelated donor hematopoietic cell transplantation for <span>Fanconi</span> anemia: Results from the <span>Severe Aplastic Anemia Working Party</span> of the <span>EBMT</span> Open
Allogeneic hematopoietic cell transplantation (HCT) is the only curative option for bone marrow failure or hematopoietic malignant diseases for Fanconi anemia (FA) patients. Although results have improved over the last decades, reaching mo…
View article: Should we use Extracorporeal Photopheresis more often? Evidence from Graft-Versus-Host Disease Patients Monitored with Treg as a Biomarker
Should we use Extracorporeal Photopheresis more often? Evidence from Graft-Versus-Host Disease Patients Monitored with Treg as a Biomarker Open
In these patients, the improvement of cGvHD, with low AEs, confirms a place for ECP as treatment. Improvements were accompanied by an increase in circulating Tregs, suggesting their role as a biomarker.
View article: Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections Open
Lipid rafts form signaling platforms on biological membranes with incompletely characterized role in immune response to infection. Here we report that lipid-raft microdomains are essential components of phagolysosomal membranes of macropha…
View article: PF763 STEM CELL TRANSPLANTATION FOR MANTLE‐CELL LYMPHOMA ‐ A SINGLE CENTRE EXPERIENCE (2010–2018)
PF763 STEM CELL TRANSPLANTATION FOR MANTLE‐CELL LYMPHOMA ‐ A SINGLE CENTRE EXPERIENCE (2010–2018) Open
Background: Mantle cell lymphoma (MCL) is a rare subtype of non‐Hodgkin lymphoma. The standard of care for MCL, include regimens containing cytarabine, followed by consolidation with autologous stem cell transplantation (auto‐HSCT) and mai…
View article: PB2321 OUTCOMES AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION FOR INHERITED BONE MARROW FAILURE SYNDROMES
PB2321 OUTCOMES AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION FOR INHERITED BONE MARROW FAILURE SYNDROMES Open
Background: Inherited Bone Marrow Failure Syndromes (IBMFS) are rare, heterogeneous disorders characterized by multiorgan disease, congenital malformations, high risk of solid tumors and hematopoietic impairment with predisposition to clon…
View article: Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections
Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections Open
SUMMARY Lipid rafts form signaling platforms on biological membranes with incompletely characterized role in immune response to infection. Here we report that lipid raft microdomains are essential components of the phagolysosomal membrane …
View article: PTX3 Polymorphisms Influence Cytomegalovirus Reactivation After Stem-Cell Transplantation
PTX3 Polymorphisms Influence Cytomegalovirus Reactivation After Stem-Cell Transplantation Open
Background: Reactivation of latent human cytomegalovirus (CMV) in patients undergoing allogeneic stem-cell transplantation (HSCT) predisposes to several clinical complications and is therefore a major cause of morbidity and mortality. Alth…