Abha Soni
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View article: Rapidly growing giant pilomatrixoma in 57-year-old Hispanic male
Rapidly growing giant pilomatrixoma in 57-year-old Hispanic male Open
Introduction: Pilomatrixomas are benign adnexal tumors arising from hair follicle matrical and cortical cells that predominantly affect the head, neck, and upper extremities in younger adults. While typically benign, challenges in treatmen…
View article: Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade
Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade Open
View article: Immune microenvironment of basal cell carcinoma and tumor regression following combined PD-1/LAG-3 blockade
Immune microenvironment of basal cell carcinoma and tumor regression following combined PD-1/LAG-3 blockade Open
Systemic treatment options for patients with locally advanced or metastatic basal cell carcinoma (BCC) are limited, particularly when tumors are refractory to anti-programmed cell death protein-1 (PD-1). A better understanding of immune ch…
View article: Supplementary Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery
Supplementary Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery Open
Supplementary Table S1. Clinicopathologic characteristics of the cohort separated by death at the 5-year time point. Supplementary Table S2. Primary and secondary antibody information and TSA dye pairings for multiplex IF panel. Supplement…
View article: Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery
Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery Open
Multiplex immunofluorescence (mIF) can detail spatial relationships and complex cell phenotypes in the tumor microenvironment (TME). However, the analysis and visualization of mIF data can be complex and time-consuming. Here, we used tumor…
View article: Supplementary Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery
Supplementary Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery Open
Supplementary Table S1. Clinicopathologic characteristics of the cohort separated by death at the 5-year time point. Supplementary Table S2. Primary and secondary antibody information and TSA dye pairings for multiplex IF panel. Supplement…
View article: Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery
Data from Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery Open
Multiplex immunofluorescence (mIF) can detail spatial relationships and complex cell phenotypes in the tumor microenvironment (TME). However, the analysis and visualization of mIF data can be complex and time-consuming. Here, we used tumor…
View article: Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Although checkpoint inhibitors that block CTLA-4 and PD-1 have improved cancer immunotherapies, targeting additional checkpoint receptors may be required to broaden patient response to immunotherapy. PVRIG is a coinhibitory receptor of the…
View article: Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Figure captions
View article: Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Figure captions
View article: Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Supplementary Figures and Tables
View article: Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Supplementary Figures and Tables
View article: Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Although checkpoint inhibitors that block CTLA-4 and PD-1 have improved cancer immunotherapies, targeting additional checkpoint receptors may be required to broaden patient response to immunotherapy. PVRIG is a coinhibitory receptor of the…
View article: A Case of Leukocytoclastic Vasculitis and Associated Conjunctivitis Following MMR Vaccine Administration
A Case of Leukocytoclastic Vasculitis and Associated Conjunctivitis Following MMR Vaccine Administration Open
Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis characterized by immune complex deposition in the walls of dermal capillaries and venules. With the COVID-19 pandemic, more adults are receiving the MMR vaccine. We report a ca…
View article: Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery
Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery Open
Multiplex immunofluorescence (mIF) can detail spatial relationships and complex cell phenotypes in the tumor microenvironment (TME). However, the analysis and visualization of mIF data can be complex and time-consuming. Here, we used tumor…
View article: PD-L1, PD-1, LAG-3, and TIM-3 in Melanoma: Expression in Brain Metastases Compared to Corresponding Extracranial Tumors
PD-L1, PD-1, LAG-3, and TIM-3 in Melanoma: Expression in Brain Metastases Compared to Corresponding Extracranial Tumors Open
View article: An Elusive Case of Mycosis Fungoides: Case Report and Review of the Literature
An Elusive Case of Mycosis Fungoides: Case Report and Review of the Literature Open
View article: Cutaneous finger and tongue metastases in renal cell carcinoma
Cutaneous finger and tongue metastases in renal cell carcinoma Open
A 54-year-old man with metastatic, undetermined subtype, renal cell carcinoma (mRCC), chronic obstructive pulmonary disease, hypertension and diabetes mellitus presented with dyspnoea and increased oxygen requirement of 5 days duration. At…
View article: Correction to: 33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018)
Correction to: 33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) Open
After publication of this supplement [1, 2], it was brought to our attention that due to an error authors were missing in the following abstracts. This has now been included in this correction.
View article: Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy
Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy Open
PURPOSE Merkel cell carcinoma (MCC) is an aggressive skin cancer often caused by the Merkel cell polyomavirus. Clinical trials of programmed cell death-1 pathway inhibitors for advanced MCC (aMCC) demonstrate increased progression-free sur…
View article: PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function Open
Although checkpoint inhibitors that block CTLA-4 and PD-1 have improved cancer immunotherapies, targeting additional checkpoint receptors may be required to broaden patient response to immunotherapy. PVRIG is a coinhibitory receptor of the…
View article: Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab
Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab Open
While the binomial presence or absence of PD-L1 expression in the TME was not sufficient to predict response to anti-PD-1 in patients with MCC, we show that quantitative assessments of PD-1+ and PD-L1+ cell densities as well as the geograp…
View article: Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma
Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma Open
Coagulation factor VIII (FVIII), von Willebrand factor (VWF), and ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats 13) play an important role in the regulation of normal hemostasis. However, little is known ab…
View article: Hepatitis C Virus Genie: A Web 2.0 Interpretation and Analytics Platform for the Versant Hepatitis C Virus Genotype Line Probe Assay Version 2.0
Hepatitis C Virus Genie: A Web 2.0 Interpretation and Analytics Platform for the Versant Hepatitis C Virus Genotype Line Probe Assay Version 2.0 Open
View article: Extramedullary Involvement by Chronic Myelogeneous Leukemia in Five Patients With Unusual Clinicopathologic Features: A Review of the Effectiveness of Tyrosine Kinase Inhibitors
Extramedullary Involvement by Chronic Myelogeneous Leukemia in Five Patients With Unusual Clinicopathologic Features: A Review of the Effectiveness of Tyrosine Kinase Inhibitors Open
Chronic myelogeneous leukemia (CML) is associated with BCR-ABL1 fusion gene leading to an abnormal tyrosine kinase molecule. The accepted first-line treatment is imatinib mesylate (IM). CML uncommonly occurs in the extramedullary sites at …
View article: Breast Cancer Subtypes Predispose the Site of Distant Metastases
Breast Cancer Subtypes Predispose the Site of Distant Metastases Open
These findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the app…
View article: Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones
Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones Open
A case of florid reactive periostitis ossificans (RPO) arising in a long bone is presented. This is a rare bone proliferation with a pronounced periosteal reaction. Less than 100 cases have been described in the literature with far fewer o…