Ajay Goel
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View article: circ-EGFR is a predictor of response to Cetuximab and a potential target in colorectal cancer
circ-EGFR is a predictor of response to Cetuximab and a potential target in colorectal cancer Open
Cetuximab, an EGFR-targeting monoclonal antibody, provides beneficial yet limited clinical improvement in KRAS wild-type metastatic colorectal cancer (mCRC). While circRNA dysregulation has been implicated in various cancers, the role of c…
View article: Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future
Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis, largely because of late‐stage diagnosis and therapeutic resistance. PDAC incidence has been rising, with modifiable and non‐modifiable risk factor…
View article: Oligomeric Proanthocyanidins Reverse Lenvatinib Resistance in Hepatocellular Carcinoma Through ITGA3-Mediated Pathway
Oligomeric Proanthocyanidins Reverse Lenvatinib Resistance in Hepatocellular Carcinoma Through ITGA3-Mediated Pathway Open
Background: Oligomeric proanthocyanidins (OPCs) are natural polyphenolic compounds with strong antitumor properties and have gained attention as potential agents to overcome drug resistance. Hepatocellular carcinoma (HCC) remains a major c…
View article: Exosomal ALPPL2 and THBS2 as biomarkers for early detection and disease monitoring of pancreatic ductal adenocarcinoma
Exosomal ALPPL2 and THBS2 as biomarkers for early detection and disease monitoring of pancreatic ductal adenocarcinoma Open
View article: A machine-learning powered liquid biopsy predicts response to Paclitaxel plus Ramucirumab in advanced gastric cancer: Results from the prospective IVY trial
A machine-learning powered liquid biopsy predicts response to Paclitaxel plus Ramucirumab in advanced gastric cancer: Results from the prospective IVY trial Open
Background Paclitaxel plus ramucirumab (PTX + RAM) is a widely used second-line treatment for advanced gastric cancer, yet no validated biomarkers exist to predict therapeutic response. Identifying non-invasive predictors could enable pati…
View article: Fusobacterium nucleatum Is Associated with Tumor Characteristics, Immune Microenvironment, and Survival in Appendiceal Cancer
Fusobacterium nucleatum Is Associated with Tumor Characteristics, Immune Microenvironment, and Survival in Appendiceal Cancer Open
Emerging evidence highlights the role of the tumor microbiome, including Fusobacterium nucleatum (Fn), in a wide range of gastrointestinal cancers. Fn purportedly contributes to tumorigenesis by activating oncogenic pathways and modulating…
View article: Prediction of long-term recurrence-free and overall survival in early-onset colorectal cancer: the ENCORE multi-centre study
Prediction of long-term recurrence-free and overall survival in early-onset colorectal cancer: the ENCORE multi-centre study Open
View article: GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing
GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing Open
View article: Abstract 7459: The anticancer effects of brusatol are mediated by PPAR-γ/ME1-driven glycolysis in intrahepatic cholangiocarcinoma
Abstract 7459: The anticancer effects of brusatol are mediated by PPAR-γ/ME1-driven glycolysis in intrahepatic cholangiocarcinoma Open
Background: Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor characterized by its dense fibrotic microenvironment, which is associated with chemotherapy resistance and poor outcome. Hence, developing novel strategies to improve t…
View article: Supplementary Data 2 from An Exosome-Based Liquid Biopsy Predicts Depth of Response and Survival Outcomes to Cetuximab and Panitumumab in Metastatic Colorectal Cancer: The EXONERATE Study
Supplementary Data 2 from An Exosome-Based Liquid Biopsy Predicts Depth of Response and Survival Outcomes to Cetuximab and Panitumumab in Metastatic Colorectal Cancer: The EXONERATE Study Open
Supplementary figures
View article: Supplementary Data 1 from An Exosome-Based Liquid Biopsy Predicts Depth of Response and Survival Outcomes to Cetuximab and Panitumumab in Metastatic Colorectal Cancer: The EXONERATE Study
Supplementary Data 1 from An Exosome-Based Liquid Biopsy Predicts Depth of Response and Survival Outcomes to Cetuximab and Panitumumab in Metastatic Colorectal Cancer: The EXONERATE Study Open
Supplementary methods and data
View article: Data from An Exosome-Based Liquid Biopsy Predicts Depth of Response and Survival Outcomes to Cetuximab and Panitumumab in Metastatic Colorectal Cancer: The EXONERATE Study
Data from An Exosome-Based Liquid Biopsy Predicts Depth of Response and Survival Outcomes to Cetuximab and Panitumumab in Metastatic Colorectal Cancer: The EXONERATE Study Open
Purpose:The EXOsome and cell-free miRNAs of anti-EGFR ResistAnce (EXONERATE) study was an open-label, biomarker interventional study designed to develop, test, and validate a liquid biopsy predictive of progression-free survival (PFS), ove…
View article: Intra-Tumoral CD8+:CD3+ Lymphocyte Density Ratio in Appendix Cancer Is a Tumor Volume- and Grade-Independent Predictor of Survival
Intra-Tumoral CD8+:CD3+ Lymphocyte Density Ratio in Appendix Cancer Is a Tumor Volume- and Grade-Independent Predictor of Survival Open
Background: The immune contexture of solid tumors plays a critical role in cancer progression and response to immunotherapy. However, immunologic characterization of appendiceal cancer (AC) has lagged behind advancements in other gastroint…
View article: Correction: Roy et al. Metformin and ICG-001 Act Synergistically to Abrogate Cancer Stem Cells-Mediated Chemoresistance in Colorectal Cancer by Promoting Apoptosis and Autophagy. Cancers 2022, 14, 1281
Correction: Roy et al. Metformin and ICG-001 Act Synergistically to Abrogate Cancer Stem Cells-Mediated Chemoresistance in Colorectal Cancer by Promoting Apoptosis and Autophagy. Cancers 2022, 14, 1281 Open
In the original publication [...]
View article: Informatics strategies for early detection and risk mitigation in pancreatic cancer patients
Informatics strategies for early detection and risk mitigation in pancreatic cancer patients Open
View article: Circulating Tumor DNA Testing in Curatively Resected Colorectal Cancer and Salvage Resection
Circulating Tumor DNA Testing in Curatively Resected Colorectal Cancer and Salvage Resection Open
Importance Serial circulating tumor DNA (ctDNA) has emerged as a routine surveillance strategy for patients with resected colorectal cancer, but how serial ctDNA monitoring is associated with potential curative outcomes has not been formal…
View article: Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression Open
View article: Stool and blood biomarkers for colorectal cancer management: an update on screening and disease monitoring
Stool and blood biomarkers for colorectal cancer management: an update on screening and disease monitoring Open
Biomarker research is not just improving, but bringing a transformative change to CRC clinical management. Early detection is not just getting better, but improving thanks to a multi-modality approach, and personalized treatment plans are …
View article: Distinct Clinical Characteristics and Predictors of Sporadic Mismatch Repair-Deficient Colorectal Cancer
Distinct Clinical Characteristics and Predictors of Sporadic Mismatch Repair-Deficient Colorectal Cancer Open
View article: Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer
Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor survival rates, primarily due to the limited effectiveness of gemcitabine (Gem)-based chemotherapy, as well as the acquisition of chemotherapeutic resistance. Aro…
View article: An exosome‐based liquid biopsy signature for therapeutic response prediction in metastatic gastric cancer
An exosome‐based liquid biopsy signature for therapeutic response prediction in metastatic gastric cancer Open
Dear Editor, Systemic chemotherapy based on fluorouracil or fluoropyrimidine + platinum is recommended as first-line chemotherapy for patients with metastatic gastric cancer (mGC)1, 2; however, the efficacy of such treatment regimens remai…
View article: LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA
LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA Open
View article: Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers
Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers Open
View article: Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles
Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles Open
View article: Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA Open
View article: Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer
Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer Open
Background Tumor-associated antigen (TAA)-specific CD8(+) T cells are essential for nivolumab therapy, and irradiation has been reported to have the potential to generate and activate TAA-specific CD8(+) T cells. However, mechanistic insig…
View article: Effective standardisation and personalisation optimise the management of acute lymphoblastic leukaemia maintenance treatment and improve outcomes
Effective standardisation and personalisation optimise the management of acute lymphoblastic leukaemia maintenance treatment and improve outcomes Open
View article: The Non-Coding RNA Journal Club: Highlights on Recent Papers—13
The Non-Coding RNA Journal Club: Highlights on Recent Papers—13 Open
We are delighted to share with you our thirteenth Journal Club and highlight some of the most interesting papers published recently [...]
View article: Issue Information
Issue Information Open
View article: A Circulating Panel of circRNA Biomarkers for the Noninvasive and Early Detection of Pancreatic Ductal Adenocarcinoma
A Circulating Panel of circRNA Biomarkers for the Noninvasive and Early Detection of Pancreatic Ductal Adenocarcinoma Open