Abhijit Kale
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View article: Role of immune cells in the removal of deleterious senescent cells
Role of immune cells in the removal of deleterious senescent cells Open
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissu…
View article: The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications
The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications Open
Proteomic and multi-omic approaches will be important for the development of senescence-based biomarkers to facilitate and monitor future therapeutic interventions that target senescent cells.
View article: A proteomic atlas of senescence-associated secretomes for aging biomarker development
A proteomic atlas of senescence-associated secretomes for aging biomarker development Open
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically …
View article: Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38<sup>+</sup>pro-inflammatory macrophages
Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38<sup>+</sup>pro-inflammatory macrophages Open
Summary Decline in tissue NAD levels during aging is linked to aging and its associated diseases. However, the mechanism for aging-associated NAD decline remains unclear. Here we report that pro-inflammatory M1-like macrophages, but not na…
View article: A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development
A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development Open
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of, and promising therapeutic target for, multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typicall…
View article: Tumor evolution: Multiple induction mechanisms for cell competition
Tumor evolution: Multiple induction mechanisms for cell competition Open
Tumor cells often differ genetically from normal cells and from one another. Competitive interactions can occur between genetically-distinct cells, and recent studies highlight multiple examples where cell competition initiates using disti…
View article: Local Cell Death Changes the Orientation of Cell Division in the Developing Drosophila Wing Imaginal Disc Without Using Fat or Dachsous as Orienting Signals
Local Cell Death Changes the Orientation of Cell Division in the Developing Drosophila Wing Imaginal Disc Without Using Fat or Dachsous as Orienting Signals Open
Drosophila imaginal disc cells exhibit preferred cell division orientations according to location within the disc. These orientations are altered if cell death occurs within the epithelium, such as is caused by cell competition or by genot…