Abhinandan Devaprasad
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View article: A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals
A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals Open
CD4 T helper cells (TH cells) play a vital role in coordinating and amplifying the immune response to specific pathogens. They constitutively produce different kinds of extracellular vesicles (EVs), which mediate cell-to cell communication…
View article: Zfp263 is a transcriptional checkpoint of neutrophil development
Zfp263 is a transcriptional checkpoint of neutrophil development Open
During development neutrophils undergo extensive changes in nuclear morphology, gene expression programmes, and acquire specific effector functions. However, molecular mechanisms controlling neutrophil development remain largely unknown. H…
A systems approach to unraveling progenitor potential and disease-associated immune cell networks. Open
The immune system plays a significant role in many immune and non-immune-mediated diseases' pathophysiology, it is imperative to holistically understand the many immune cell types, emphasizing their origin, function, and regulation. The or…
Enrichment of SARS-CoV-2 Entry Factors and Interacting Intracellular Genes in Tissue and Circulating Immune Cells Open
SARS-CoV-2 uses ACE2 and TMPRSS2 to gain entry into the cell. However, recent studies have shown that SARS-CoV-2 may use additional host factors that are required for the viral lifecycle. Here we used publicly available datasets, CoV-assoc…
Integration of Immunome With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies Open
Objective Development and progression of immune-mediated inflammatory diseases (IMIDs) involve intricate dysregulation of the disease-associated genes (DAGs) and their expressing immune cells. Identifying the crucial disease-associated cel…
Enrichment of SARS-CoV-2 entry factors and interacting intracellular genes in peripheral immune cells Open
SARS-CoV-2 uses ACE2 and TMPRSS2 to gain entry into the cell. However, recent studies have shown that SARS-CoV-2 may use additional host factors that are required for the viral lifecycle. Here we used publicly available datasets, CoV assoc…
View article: CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cells in vitro
CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cells in vitro Open
Fibrosis is a condition shared by numerous inflammatory diseases. Our incomplete understanding of the molecular mechanisms underlying fibrosis has severely hampered effective drug development. CXCL4 is associated with the onset and extent …
View article: CXCL4 links inflammation and fibrosis through transcriptional and epigenetic reprogramming of monocyte-derived cells
CXCL4 links inflammation and fibrosis through transcriptional and epigenetic reprogramming of monocyte-derived cells Open
Fibrosis is a condition shared by numerous inflammatory diseases. Our incomplete understanding of the molecular mechanisms underlying fibrosis has severely hampered effective drug development. CXCL4 is associated with the onset and extent …
Neutrophil GM-CSF receptor dynamics in acute lung injury Open
GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process essential for signa…
A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis Open
PURPOSE. The cause of noninfectious uveitis (NIU) is poorly understood but is considered to be mediated by a complex interplay between genetic, environmental, and-relatively unexplored-epigenetic factors. MicroRNAs (miRNAs) are noncoding s…
Meta-analysis of host response networks identifies a common core in tuberculosis Open
Tuberculosis remains a major global health challenge worldwide, causing more than a million deaths annually. To determine newer methods for detecting and combating the disease, it is necessary to characterise global host responses to infec…