Abhinay Kumar Singh
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View article: Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer’s Disease
Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer’s Disease Open
Protein kinases are important molecules of Alzheimer’s Disease (AD), driving neuronal demise and the emergence of the disease’s destructive hallmarks. Cdk5 has recently been highlighted as a key therapeutic target for AD. This study evalua…
View article: Impact of hemolysis on the levels of proteins associated with aging and age-related neurodegenerative diseases in a multicentric clinical research
Impact of hemolysis on the levels of proteins associated with aging and age-related neurodegenerative diseases in a multicentric clinical research Open
View article: Serum Klotho: Unraveling its association with diagnosis and prognosis of breast cancer
Serum Klotho: Unraveling its association with diagnosis and prognosis of breast cancer Open
This study contributes a novel finding of serum Klotho protein in BC pathogenesis and explores its utility as a blood-based biomarker.
View article: Evaluation of serum level of seven Sirtuins in Alzheimer’s Disease patients: Biomarker based on the Translational Research
Evaluation of serum level of seven Sirtuins in Alzheimer’s Disease patients: Biomarker based on the Translational Research Open
Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder. Dysfunction of mitochondria and oxidative stress are known to aggravate the disease pathology. Sirtuins, NAD‐dependent deacetylases, have a well‐defined …
View article: Organic light-emitting diode therapy promotes longevity through the upregulation of SIRT1 in senescence-accelerated mouse prone 8 mice
Organic light-emitting diode therapy promotes longevity through the upregulation of SIRT1 in senescence-accelerated mouse prone 8 mice Open
Phototherapy has been extensively used to prevent and treat signs of aging and stimulate wound healing, and phototherapy through light-emitting diodes (LEDs). In contrast to LED, organic LED (OLED) devices are composed of organic semicondu…
View article: Circulatory GSK‐3beta a new target against Alzheimer’s disease
Circulatory GSK‐3beta a new target against Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the progressive brain disorder which degenerate brain cells connection and causes memory loss. Though, AD is irreversible, it is not impossible to arrest or slow down the progression of the disease. H…
View article: Level of blood Tau and p‐Tau : a non‐invasive approach for the diagnosis of Alzheimer’s Disease(AD)
Level of blood Tau and p‐Tau : a non‐invasive approach for the diagnosis of Alzheimer’s Disease(AD) Open
Background Prominent expression of Tau and phosphorylated Tau in cerebrospinal fluid (CSF) is one of the well‐known hallmarks of the Alzheimer’s disease (AD). High levels of p‐Tau can easily differentiate AD from other neurodegenerative di…
View article: Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human Open
Background Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheumatoid OA, and temporomandibular joint (TMJ) OA. TMJ-OA is a common disease associated with an imbalance o…
View article: AGA induces sub-G1 cell cycle arrest and apoptosis in human colon cancer cells through p53-independent/p53-dependent pathway
AGA induces sub-G1 cell cycle arrest and apoptosis in human colon cancer cells through p53-independent/p53-dependent pathway Open
View article: Predictors of Survival Among the Oldest Old Following Acute Hospital Admission: Insights From Clinical and Biochemical Factors
Predictors of Survival Among the Oldest Old Following Acute Hospital Admission: Insights From Clinical and Biochemical Factors Open
Understanding the factors influencing survival in oldest old population is crucial for providing appropriate care and improving outcomes. This prospective observational study aimed to investigate the determinants of survival in acutely ill…
View article: Circulatory Level of Inflammatory Cytoskeleton Signaling Regime Proteins in Cancer Invasion and Metastasis
Circulatory Level of Inflammatory Cytoskeleton Signaling Regime Proteins in Cancer Invasion and Metastasis Open
Early detection of metastatic breast cancer (MBC) is a serious issue for the healthcare system. It is essential to develop potential non-invasive, low-cost molecular biomarkers. The present study explored specific serum proteins of inflamm…
View article: Platelet-Derived Biomaterials Exert Chondroprotective and Chondroregenerative Effects on Diabetes Mellitus-Induced Intervertebral Disc Degeneration
Platelet-Derived Biomaterials Exert Chondroprotective and Chondroregenerative Effects on Diabetes Mellitus-Induced Intervertebral Disc Degeneration Open
Complications of diabetes mellitus (DM) range from acute to chronic conditions, leading to multiorgan disorders such as nephropathy, retinopathy, and neuropathy. However, little is known about the influence of DM on intervertebral disc deg…
View article: Blood Circulatory Level of Seven Sirtuins in Alzheimer’s Disease: Potent Biomarker Based on Translational Research
Blood Circulatory Level of Seven Sirtuins in Alzheimer’s Disease: Potent Biomarker Based on Translational Research Open
Alzheimer's disease (AD) is an accelerating neurodegenerative disorder. Dysfunction of mitochondria and oxidative stress contributes to the pathogenesis of AD. Sirtuins play a role in this pathway and can be a potential marker to study neu…
View article: Blood circulatory level of seven sirtuins in Alzheimer’s disease: Potent biomarker based on translational research
Blood circulatory level of seven sirtuins in Alzheimer’s disease: Potent biomarker based on translational research Open
Alzheimer's disease (AD) is an accelerating neurodegenerative disorder. Dysfunction of mitochondria and oxidative stress contributes to the pathogenesis of AD. Sirtuins play a role in this pathway and can be a potential marker to study neu…
View article: Amelioration of Nicotine-Induced Osteoarthritis by Platelet-Derived Biomaterials Through Modulating IGF-1/AKT/IRS-1 Signaling Axis
Amelioration of Nicotine-Induced Osteoarthritis by Platelet-Derived Biomaterials Through Modulating IGF-1/AKT/IRS-1 Signaling Axis Open
Besides inhalation, a few studies have indicated that the uptake of nicotine through air or clothing may be a significant pathway of its exposure among passive smokers. Nicotine is well known to exert various physiological impacts, includi…
View article: Waste heat recovery from diesel engine using custom designed heat exchanger and thermal storage system with nanoenhanced phase change material
Waste heat recovery from diesel engine using custom designed heat exchanger and thermal storage system with nanoenhanced phase change material Open
In this research study an attempt has been made to recover the heat energy of the exhaust gas from a Diesel engine, using a triangular finned shell and tube heat exchanger with segmental baffle at 20?, and efficiently store as sensible and…
View article: Ilizarov fixator in management of nonunited and infected tibial shaft fractures
Ilizarov fixator in management of nonunited and infected tibial shaft fractures Open
Background: Management of nonunion with bony defect and infection in long bones is a challenging problem for orthopedic surgeons. Objectives: Evaluation of Ilizarov circular fixation method of treatment for the management of nonunited and …