Abhishek Poddar
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View article: Localization of Fascin to Dendritic Protrusions Regulates Postsynaptic Plasticity
Localization of Fascin to Dendritic Protrusions Regulates Postsynaptic Plasticity Open
The Fascin family of actin-bundling proteins organizes actin filaments (F-actin) into tightly packed bundles that drive dynamic membrane protrusions such as filopodia. In neurons, fascin has been thought to primarily function in axons, as …
View article: Unraveling Attention-Deficit/Hyperactivity Disorder Etiology: Current Challenges and Future Directions in Treatment
Unraveling Attention-Deficit/Hyperactivity Disorder Etiology: Current Challenges and Future Directions in Treatment Open
Attention-Deficit/Hyperactivity Disorder (ADHD) is a complex neurodevelopmental disorder with a multifactorial etiology involving genetic, epigenetic, and environmental factors. This review focuses on the current understanding of these con…
View article: Demographic and Clinical Characteristics of Inguinal Hernia Patients: ARetrospective Analysis
Demographic and Clinical Characteristics of Inguinal Hernia Patients: ARetrospective Analysis Open
Background: Inguinal hernia is among the most common surgical conditions in the world and causesapproximately 75% of all abdominal wall hernias. Pathogenesis is polyfactorial with anatomical, occupational,and possibly genetic determinants.…
View article: Retrospective Evaluation of Predictive Risk Factors for Difficult Laparoscopic Cholecystectomy
Retrospective Evaluation of Predictive Risk Factors for Difficult Laparoscopic Cholecystectomy Open
Background: Laparoscopic cholecystectomy (LC) is the gold standard treatment of symptomatic gallstone disease. LC is considered minimally invasive surgery and with some challenging cases, this may require conversion to open surgery. Correc…
View article: Advancing CRISPR-Based Solutions for COVID-19 Diagnosis and Therapeutics
Advancing CRISPR-Based Solutions for COVID-19 Diagnosis and Therapeutics Open
Since the onset of the COVID-19 pandemic, a variety of diagnostic approaches, including RT-qPCR, RAPID, and LFA, have been adopted, with RT-qPCR emerging as the gold standard. However, a significant challenge in COVID-19 diagnostics is the…
View article: GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade
GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade Open
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and …
View article: The Mechanosensitive Pkd2 Channel Modulates the Recruitment of Myosin II and Actin to the Cytokinetic Contractile Ring
The Mechanosensitive Pkd2 Channel Modulates the Recruitment of Myosin II and Actin to the Cytokinetic Contractile Ring Open
Cytokinesis, the last step in cell division, separates daughter cells through mechanical force. This is often through the force produced by an actomyosin contractile ring. In fission yeast cells, the ring helps recruit a mechanosensitive i…
View article: The mechanosensitive Pkd2 channel modulates the recruitment of myosin II and actin to the cytokinetic contractile ring
The mechanosensitive Pkd2 channel modulates the recruitment of myosin II and actin to the cytokinetic contractile ring Open
Cytokinesis, the last step in cell division, separate daughter cells through the force produced by an actomyosin contractile ring assembled at the equatorial plane. In fission yeast cells, the ring helps recruit a mechanosensitive ion chan…
View article: GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade
GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade Open
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and …
View article: Interactive Effect Among Competition, Pricing and Liquidity – Evidence from Indian Banking System
Interactive Effect Among Competition, Pricing and Liquidity – Evidence from Indian Banking System Open
View article: Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis
Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis Open
The fission yeast polycystin channel Pkd2 is required for the expansion of cell volume during cell growth and cytokinesis. Here, we discovered that Pkd2 is permeable to calcium when it is activated by membrane stretching, and this putative…
View article: Membrane stretching activates calcium-permeability of a putative channel Pkd2 during fission yeast cytokinesis
Membrane stretching activates calcium-permeability of a putative channel Pkd2 during fission yeast cytokinesis Open
Pkd2 is the fission yeast homolog of polycystins. This putative ion channel localizes to the plasma membrane. It is required for the expansion of cell volume during interphase growth and cytokinesis, the last step of cell division. However…
View article: Exomer Is Part of a Hub Where Polarized Secretion and Ionic Stress Connect
Exomer Is Part of a Hub Where Polarized Secretion and Ionic Stress Connect Open
Plasma membrane and membranous organelles contribute to the physiology of the Eukaryotic cell by participating in vesicle trafficking and the maintenance of ion homeostasis. Exomer is a protein complex that facilitates vesicle transport fr…
View article: Potential Wound Healing Properties of a Polyherbal Formulation (Amrit oil) in an Experimental Model on Wistar Rats
Potential Wound Healing Properties of a Polyherbal Formulation (Amrit oil) in an Experimental Model on Wistar Rats Open
Introduction and Aim: Wound healing is an integrated process of cellular and biochemical events in restoring the structural functionality of the damaged tissue caused due to wounds. In the present study, the wound healing potential of an a…
View article: Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis
Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis Open
Calcium rises transiently at the division plane during cytokinesis of embryonic cells, but the conservation and function of such calcium transients remain unclear. We discovered similar calcium spikes during fission yeast cytokinesis, and …
View article: Calcium spikes accompany the cleavage furrow ingression and cell separation during fission yeast cytokinesis
Calcium spikes accompany the cleavage furrow ingression and cell separation during fission yeast cytokinesis Open
The role of calcium signaling during cytokinesis has long remained ambiguous. The studies of embryonic cell division discovered that calcium concentration increases transiently at the division plane just before the cleavage furrow ingressi…
View article: Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis
Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis Open
Force plays a central role in separating daughter cells during cytokinesis, the last stage of cell division. However, the mechanism of force sensing during cytokinesis remains unknown. Here we discovered that Pkd2p, a putative force-sensin…
View article: Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis
Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis Open
Force plays a central role in separating daughter cells during cytokinesis, the last stage of cell division. However, the mechanism of force-sensing during cytokinesis remains unknown. Here we discovered that Pkd2p, a putative force-sensin…