Ralph J. Abi‐Habib
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View article: Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)
Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review) Open
Ferroptosis is a type of programmed cell death characterized by accumulation of free iron, reactive oxygen species generation and lipid peroxidation and is distinct from other types of regulated cell deaths such as apoptosis, necrosis and …
View article: Key genes altered in glioblastoma based on bioinformatics (Review)
Key genes altered in glioblastoma based on bioinformatics (Review) Open
Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis. Recent advancements in bioinformatics have contributed to uncovering the genetic alterations that underlie the development and progression of GBM. Analysis of …
View article: Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)
Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review) Open
Genetic alterations drive tumor onset and progression. However, the cross‑talk between tumor cells and the benign components of the surrounding stroma can also promote the initiation, progression and metastasis of solid tumors. These cellu…
View article: Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA
Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA Open
View article: Recombinant anthrax lethal toxin inhibits cell motility and invasion in breast cancer cells through the dysregulation of Rho GTPases
Recombinant anthrax lethal toxin inhibits cell motility and invasion in breast cancer cells through the dysregulation of Rho GTPases Open
Breast cancer is the leading cause of cancer-associated death among women worldwide. Targeting breast cancer cell metastasis is an important therapeutic approach. The MAPK pathway is a key cell signaling pathway that plays a pivotal role i…
View article: Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review
Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review Open
View article: Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion
Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion Open
Purpose: Colorectal cancer (CRC) is the third most common type of cancer worldwide, and it represents over half of all gastrointestinal cancer deaths. Knowing that cancer cells have a high proliferation rate, they require high amounts of a…
View article: PO-065 Arginine deprivation through human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000] activates autophagy and leads to autophagy-mediated cell death in glioblastoma cells
PO-065 Arginine deprivation through human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000] activates autophagy and leads to autophagy-mediated cell death in glioblastoma cells Open
Introduction Arginine auxotrophy, secondary to a lack of argininosuccinate synthetase-1 (ASS-1) expression, is a hallmark of several tumour types allowing for their selective targeting using arginine deprivation. HuArgI (Co)-PEG5000, a re…
View article: Phototoxicity of strained Ru(<scp>ii</scp>) complexes: is it the metal complex or the dissociating ligand?
Phototoxicity of strained Ru(<span>ii</span>) complexes: is it the metal complex or the dissociating ligand? Open
This work exemplifies the potential potency of photochemically ejected ligands from strained Ru(ii) polypyridyl complexes used in photoactivated chemotherapy.
View article: Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion
Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion Open
Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Understanding and targeting cancer cell invasion is an important therapeutic approach. Cell invasion is a complex process that replies on man…
View article: Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF)
Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) Open
In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax …
View article: Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells
Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells Open
In this study, we used Daucus carota oil extract (DCOE) to target acute myeloid leukemia (AML) cells. All the AML cell lines tested were sensitive to the extract while peripheral mononuclear cells were not. Analysis of mechanism of cell de…