Syed Adnan Alı Shah
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View article: Factors Affecting Health-Related Quality of Life in Tuberculosis Patients: A Systematic Review
Factors Affecting Health-Related Quality of Life in Tuberculosis Patients: A Systematic Review Open
Objective: To systematically review and synthesize published evidence on the physical, psychosocial, and socioeconomic factors influencing health-related quality of life (HRQoL) among patients with tuberculosis (TB). Data Sources: This stu…
View article: P076 Anti-HMGCR-associated necrotising myopathy: atypical clinical course of a rare condition
P076 Anti-HMGCR-associated necrotising myopathy: atypical clinical course of a rare condition Open
Introduction Autoimmune inflammatory myopathy is a rare condition characterised by proximal muscle weakness and elevated muscle enzymes. Autoimmune necrotising myopathy is the second commonest subclass of inflammatory myopathies (INM). The…
View article: P072 A case of anti-synthetase syndrome presenting as psoriatic mono-arthritis
P072 A case of anti-synthetase syndrome presenting as psoriatic mono-arthritis Open
Introduction Inflammatory (seronegative) arthritis can be an initial presentation of a multisystem disorder. One such condition is anti-synthetase syndrome, which is a subtype of idiopathic inflammatory myopathy, strongly associated with t…
View article: P079 A challenging case of anti-SRP-associated immune-mediated necrotising myopathy in a young patient
P079 A challenging case of anti-SRP-associated immune-mediated necrotising myopathy in a young patient Open
Introduction Idiopathic inflammatory myopathies (IIMs) are a heterogeneous disease group characterised by a subacute course of muscle weakness and inflammatory muscle changes that are presumed to be caused by autoimmune mechanisms. Immune-…
View article: Fabrication of Carboxymethyl Cellulose Supported Bi-Fe Nano Catalyst for the Removal of Dyes from Aqueous Medium under Direct Sunlight Radiation
Fabrication of Carboxymethyl Cellulose Supported Bi-Fe Nano Catalyst for the Removal of Dyes from Aqueous Medium under Direct Sunlight Radiation Open
Carboxymethyl cellulose (CMC) supported Bi-Fe nanocomposite is synthesized by very simple, cost effective and environment friendly co-precipitation method. The characterization of the synthesized Carboxymethyl cellulose (CMC) supported Bi-…
View article: Computational Evaluation of Azinane–Amide-Coupled Triazoles Enabled by an Alkali Metal Reagent as Anti-Enzymatic Agents
Computational Evaluation of Azinane–Amide-Coupled Triazoles Enabled by an Alkali Metal Reagent as Anti-Enzymatic Agents Open
A new electrophile was synthesized and merged with 1,2,4-triazole and piperidine to avail the aimed library of compounds, 10a i‑v and 10b i‑v . Various 4-(substituted)-benzenesulfonyl chlor…
View article: Synthesis, characterization, biological and in-silico evaluation of cuminaldehyde derivatives
Synthesis, characterization, biological and in-silico evaluation of cuminaldehyde derivatives Open
Cuminum cyminum L. is a versatile spice belonging to the family Apiaceae. It exhibits numerous culinary, traditional, and pharmacological attributes. All therapeutic effectiveness of C. cyminum is rendered by its active phytoconstituents. …
View article: THE TUBERCULOSIS CRISIS IN PAKISTAN: CURRENT TRENDS, MAJOR CHALLENGES, AND THE NEED FOR AN INTEGRATED APPROACH : A NARRATIVE REVIEW
THE TUBERCULOSIS CRISIS IN PAKISTAN: CURRENT TRENDS, MAJOR CHALLENGES, AND THE NEED FOR AN INTEGRATED APPROACH : A NARRATIVE REVIEW Open
Background: Tuberculosis (TB) remains a major public health challenge in Pakistan, ranking fifth globally in terms of incidence and contributing significantly to morbidity and mortality. Despite advances in global TB control, Pakistan cont…
View article: Design, Synthesis, and Computational Studies of Novel <i>N-</i>(Substituted phenyl)-3-(5-((naphthalen-2-yloxy)methyl)-4-phenyl-4<i>H</i>-1,2,4-triazol-3-ylthio)acetamides as Potent Acetylcholinesterase Inhibitors
Design, Synthesis, and Computational Studies of Novel <i>N-</i>(Substituted phenyl)-3-(5-((naphthalen-2-yloxy)methyl)-4-phenyl-4<i>H</i>-1,2,4-triazol-3-ylthio)acetamides as Potent Acetylcholinesterase Inhibitors Open
The current studies elaborate the synthesis of some new N-(substituted phenyl)-3-(5-((naphthalen-2-yloxy)-methyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)-acetamides (8a-8h). This novel synthesis was accomplished by …
View article: Novel 4-quinolone derivative inflicted cytotoxicity via intrinsic apoptotic pathway activation on human metastatic triple-negative breast cancer cells
Novel 4-quinolone derivative inflicted cytotoxicity via intrinsic apoptotic pathway activation on human metastatic triple-negative breast cancer cells Open
Quinolones are a class of compounds that have shown promising potential as anticancer agents. However, the current quinolones in clinical trials are currently hampered by their efficacy issues. Therefore, we designed and synthesized novel …
View article: Chaotic, bifurcation, sensitivity, modulation stability analysis, and optical soliton structure to the nonlinear coupled Konno–Oono system in magnetic field
Chaotic, bifurcation, sensitivity, modulation stability analysis, and optical soliton structure to the nonlinear coupled Konno–Oono system in magnetic field Open
In this research work, the nonlinear coupled Konno–Oono (CKO) system is under examination to explore the dynamical soliton wave structure in the magnetic field through two distinct approaches with qualitative analysis. The magnetic potenti…
View article: Acylhydrazone derivatives of barbituric acid: Synthesis, in vitro α-amylase inhibition, molecular docking, ADMET and DFT analysis
Acylhydrazone derivatives of barbituric acid: Synthesis, in vitro α-amylase inhibition, molecular docking, ADMET and DFT analysis Open
In this study, a new series of acylhydrazones of barbituric acid were successfully synthesized and characterized through mass, 1H and 13C NMR spectroscopy. The compounds (4a-f) were assessed for their in vitro α-amylase inhibitory activity…
View article: <scp>AgriSage</scp>: Android‐Based Application for Empowering Farmers With E‐Commerce and <scp>AI</scp>‐Driven Disease Detection
<span>AgriSage</span>: Android‐Based Application for Empowering Farmers With E‐Commerce and <span>AI</span>‐Driven Disease Detection Open
Agriculture faces critical challenges such as timely disease detection, fragmented market access, and limited use of real‐time technology in the field. To address these issues, we developed AgriSage, an Android‐based intelligent mobile app…
View article: Novel triazole-based coumarin compounds as acetylcholinesterase inhibitors: Evidence and mechanism of 3-acetyl coumarin tethered (2-bromophenyl)-1,2,3 triazole as a potential mixed type inhibitor
Novel triazole-based coumarin compounds as acetylcholinesterase inhibitors: Evidence and mechanism of 3-acetyl coumarin tethered (2-bromophenyl)-1,2,3 triazole as a potential mixed type inhibitor Open
Acetylcholinesterase (AChE) inhibition remains an important therapeutic strategy for Alzheimer's diseases, prompting immense research for novel and efficient small-molecule inhibitors. In this context, the present study describes the synth…
View article: Evaluating the Safety and Efficacy of Moderate-Intensity Statin Combined With Ezetimibe in Elderly Patients With Atherosclerotic Cardiovascular Disease
Evaluating the Safety and Efficacy of Moderate-Intensity Statin Combined With Ezetimibe in Elderly Patients With Atherosclerotic Cardiovascular Disease Open
Combining moderate-intensity statins with ezetimibe is an effective and safe lipid-lowering strategy for elderly patients with ASCVD. The regimen achieved high rates of LDL-C goal attainment with minimal side effects and good adherence, ma…
View article: Synthesis of 2?,7?-Dichlorofluorescein Hydrazide Derivatives as Potential Fluorescent Sensors
Synthesis of 2?,7?-Dichlorofluorescein Hydrazide Derivatives as Potential Fluorescent Sensors Open
Optical sensors have proven to be worthwhile alternatives to traditional sensors suitable for various sensing applications. In this context, small-molecule fluorescent probes have recently gained popularity in identifying multiple analytes…
View article: First Report on Nitrogen’s Role in Vivipary Suppression in Late-Maturing Mango cv. Sufaid Chaunsa
First Report on Nitrogen’s Role in Vivipary Suppression in Late-Maturing Mango cv. Sufaid Chaunsa Open
Punjab is the major mango producing region in Pakistan whereas Pakistan is fifth in the globe in mango production. Among the late season varieties with an 18 % share in Punjab’s mango area, the premium Sufaid Chaunsa variety has an exponen…
View article: Hybrid <scp>CNN</scp>–<scp>LSTM</scp> Model With Soft Attention Mechanism for Short‐Term Load Forecasting in Smart Grid
Hybrid <span>CNN</span>–<span>LSTM</span> Model With Soft Attention Mechanism for Short‐Term Load Forecasting in Smart Grid Open
Integrating renewable energy in smart grids enables sustainable energy development but introduces challenges in supply–demand variability. Deep learning techniques are now imperative for Short‐Term Load Forecasting (STLF), a significant en…
View article: Conservatively managed non-functioning pituitary macroadenomas—cohort study from the UK Non-functioning Pituitary Adenoma Consortium
Conservatively managed non-functioning pituitary macroadenomas—cohort study from the UK Non-functioning Pituitary Adenoma Consortium Open
Objective Surveillance is often adopted for asymptomatic non-functioning pituitary macroadenomas (macroNFPAs). Due to low-quality evidence, uncertainty remains on optimal frequency of imaging/biochemical monitoring and indications for surg…
View article: Maize in 2034: A Decade of Growth, Innovation, and Sustainability in Crop Production
Maize in 2034: A Decade of Growth, Innovation, and Sustainability in Crop Production Open
Maize (Zea mays L.) is a major world cereal grain and an important food, feed and raw material crop. This review looks at the changing role of maize in the world’s agriculture, but with an emphasis on the challenges and opportunities that …
View article: Synthesis and In Vitro Evaluation of Triazole‐Based <i>N</i> ‐(Substituted phenyl)‐5‐[(benzyl)‐4‐(phenyl)‐4 <i>H</i> ‐1,2,4‐triazol‐3‐ylthio]acetamides as Potent Acetylcholinesterase Inhibitors
Synthesis and In Vitro Evaluation of Triazole‐Based <i>N</i> ‐(Substituted phenyl)‐5‐[(benzyl)‐4‐(phenyl)‐4 <i>H</i> ‐1,2,4‐triazol‐3‐ylthio]acetamides as Potent Acetylcholinesterase Inhibitors Open
The aim of this study was to design and evaluate the potential of some new acetylcholinesterase (AChE) inhibitors, encompassing biologically important acetamides, and 1,2,4‐triazole moieties structural amalgamation. A series of N ‐(substit…
View article: Comparative evaluation of phytochemical screening, in vitro antioxidant & α-Glucosidase inhibitory properties of <i>Ceiba pentandra</i> & <i>Basella rubra</i> leaf extracts: Identification of active principles by Q-TOFLCMS, ADMET prediction & molecular docking approach
Comparative evaluation of phytochemical screening, in vitro antioxidant & α-Glucosidase inhibitory properties of <i>Ceiba pentandra</i> & <i>Basella rubra</i> leaf extracts: Identification of active principles by Q-TOFLCMS, ADMET prediction & molecular docking approach Open
Ceiba pentandra and Basella rubra leaves are traditionally used in Indonesia to treat ailments like diabetes. This study aimed to validate their use by assessing their antioxidant and α-glucosidase inhibitory properties. Initially, macerat…
View article: Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin‐Thiosemicarbazide Analogues and Molecular Docking Study
Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin‐Thiosemicarbazide Analogues and Molecular Docking Study Open
Alzheimer's is a long‐term neurodegenerative illness that causes brain cells to deteriorate and has an especially negative impact on a person's capacity for independent functioning. Despite ongoing research, there is no effective cure for …
View article: Compact Neural TTS Voices for Accessibility
Compact Neural TTS Voices for Accessibility Open
Contemporary text-to-speech solutions for accessibility applications can typically be classified into two categories: (i) device-based statistical parametric speech synthesis (SPSS) or unit selection (USEL) and (ii) cloud-based neural TTS.…
View article: A review on multi-therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine: Experimental evidence and future perspectives
A review on multi-therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine: Experimental evidence and future perspectives Open
Mitragyna speciosa (kratom) is a traditional medicinal plant of Southeast Asia, known for its pharmacologically active alkaloids, mitragynine and 7-hydroxymitragynine. The chemistry, isolation, pharmacological properties, and toxicities of…
View article: Assessment of Change in Cytokine and Chemokine Profile with Antioxidant Therapy in Allergic Rhinitis
Assessment of Change in Cytokine and Chemokine Profile with Antioxidant Therapy in Allergic Rhinitis Open
View article: Kosali Cattle of Chhattisgarh: A Climate Resilient Indigenous Breed for sustainable Livestock Systems in India
Kosali Cattle of Chhattisgarh: A Climate Resilient Indigenous Breed for sustainable Livestock Systems in India Open
The Kosali cattle, an important indigenous breed of Chhattisgarh, has gained attention for its exceptional climate resilience and adapting abilities to extreme agro-climatic conditions. This paper explores the phenotypic characteristics, g…
View article: Enhancing Wind Power Forecasting in Power Grids With Dual Attention‐based LSTM Mechanism
Enhancing Wind Power Forecasting in Power Grids With Dual Attention‐based LSTM Mechanism Open
Power grid operators must deal with sustainable energy integration challenges because wind power supply and demand patterns show natural variability. The precise prediction of wind power supplies is critical to grid efficiency because it c…
View article: Cox-1 Gene-Based Identification and Molecular Phylo-genetics of Horseflies
Cox-1 Gene-Based Identification and Molecular Phylo-genetics of Horseflies Open
The hematophagous flies of the family Tabanidae are involved in the transmission of various disease-causative agents such as protozoans, helminths, bacteria, and viruses. However, molecular research on this family is not conducted in Pakis…
View article: Recent advances in zirconium-based catalysis and its applications in organic synthesis: a review
Recent advances in zirconium-based catalysis and its applications in organic synthesis: a review Open
The synthesis of various heterocycles such as imidazoles, pyrazole, pyrimidinones, quinolines, pyridines, and pyrroles via zirconium-based complexes, such as nano-ZrO 2 , BSA@α-ZrP, Fe 3 O 4 @MCM-41@ZrCl 2 , GO-ZrPPh, and HMS/Pr-Rh-Zr, is …