Abigail G. Schindler
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View article: 0291 Increased Aβ Deposition Following Chronic Sleep Disruption Correlates with Altered Gliosis and AQP4 in 5xFAD Mice
0291 Increased Aβ Deposition Following Chronic Sleep Disruption Correlates with Altered Gliosis and AQP4 in 5xFAD Mice Open
Introduction Chronically dysregulated sleep is increasingly recognized as a risk factor in the development and progression of neurodegenerative disease states, including Alzheimer’s disease (AD). Despite this known association, the mechani…
View article: Mechanisms Underlying Hazardous Alcohol Use After Mild Traumatic Brain Injury
Mechanisms Underlying Hazardous Alcohol Use After Mild Traumatic Brain Injury Open
This review discusses mechanisms that contribute to negative outcomes after mTBI and hazardous alcohol use and to the development of AUD after mTBI. These include inflammation and immune signaling, neuroendocrine alterations, oxidative str…
View article: Gut Microbial Composition Is Associated with Symptom Self-Report in Trauma-Exposed Iraq and Afghanistan Veterans
Gut Microbial Composition Is Associated with Symptom Self-Report in Trauma-Exposed Iraq and Afghanistan Veterans Open
Iraq and Afghanistan War-era Veterans are at elevated risk for physical injuries and psychiatric illnesses, in particular the polytrauma triad of mild traumatic brain injury (mTBI), post-traumatic stress disorder (PTSD), and chronic pain. …
View article: Anxiety and risk-taking behavior maps onto opioid and alcohol polysubstance consumption patterns in male and female mice
Anxiety and risk-taking behavior maps onto opioid and alcohol polysubstance consumption patterns in male and female mice Open
Polysubstance use is prevalent in the population but remains understudied in preclinical models. Alcohol and opioid polysubstance use is associated with negative outcomes, worse treatment prognosis, and higher overdose risk; but underlying…
View article: Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation
Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation Open
The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological p…
View article: Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function
Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function Open
Mild traumatic brain injury (mTBI) has emerged as a potential risk factor for the development of neurodegenerative conditions such as Alzheimer’s disease and chronic traumatic encephalopathy. Blast mTBI, caused by exposure to a pressure wa…
View article: Increased [<sup>18</sup>F]Fluorodeoxyglucose Uptake in the Left Pallidum in Military Veterans with Blast-Related Mild Traumatic Brain Injury: Potential as an Imaging Biomarker and Mediation with Executive Dysfunction and Cognitive Impairment
Increased [<sup>18</sup>F]Fluorodeoxyglucose Uptake in the Left Pallidum in Military Veterans with Blast-Related Mild Traumatic Brain Injury: Potential as an Imaging Biomarker and Mediation with Executive Dysfunction and Cognitive Impairment Open
Blast-related mild traumatic brain injury (blast-mTBI) can result in a spectrum of persistent symptoms leading to substantial functional impairment and reduced quality of life. Clinical evaluation and discernment from other conditions comm…
View article: Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults
Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults Open
Importance Sleep disturbances and clinical sleep disorders are associated with all-cause dementia and neurodegenerative conditions, but it remains unclear how longitudinal changes in sleep impact the incidence of cognitive impairment. Obje…
View article: Longitudinal sleep instability predicts cognitive decline and is associated with increased MRI‐visible perivascular space burden
Longitudinal sleep instability predicts cognitive decline and is associated with increased MRI‐visible perivascular space burden Open
Background Although emerging data suggest a direct link between sleep duration, aging, and cognitive performance, the impact of longitudinal sleep patterns have on Alzheimer’s disease‐associated pathology and cognitive decline remains uncl…
View article: Longitudinal sleep instability predicts cognitive decline and is associated with increased MRI‐visible perivascular space burden
Longitudinal sleep instability predicts cognitive decline and is associated with increased MRI‐visible perivascular space burden Open
Background Although emerging data suggest a direct link between sleep duration, aging, and cognitive performance, the impact of longitudinal sleep patterns have on Alzheimer’s disease‐associated pathology and cognitive decline remains uncl…
View article: Association between gut microbiome composition and symptom self-report in trauma exposed OEF/OIF/OND Veterans
Association between gut microbiome composition and symptom self-report in trauma exposed OEF/OIF/OND Veterans Open
Objective Iraq and Afghanistan war-era (OEF/OIF/OND) Veterans are at elevated risk for physical injuries and psychiatric illnesses, in particular comorbid mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), and chroni…
View article: Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study
Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study Open
Importance Sleep disturbances and clinical sleep disorders are associated with all-cause dementia and neurodegenerative conditions. It remains unclear how longitudinal changes in sleep impact the incidence of cognitive impairment. Objectiv…
View article: Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice
Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice Open
View article: Timing matters: Sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury
Timing matters: Sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury Open
View article: Sexually dimorphic development of the mesolimbic dopamine system is associated with nuanced sensitivity to adolescent alcohol use
Sexually dimorphic development of the mesolimbic dopamine system is associated with nuanced sensitivity to adolescent alcohol use Open
Alcohol use remains a major public health concern and is especially prevalent during adolescence. Adolescent alcohol use has been linked to several behavioral abnormalities in later life, including increased risk taking and impulsivity. Ac…
View article: Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury
Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury Open
Understanding how diffuse mild traumatic brain injuries can provoke common and persistent post-concussive symptoms (PCS), such as impaired sleep, is crucial to prevent and treat chronic disability and neurodegeneration. We mapped the spati…
View article: The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma
The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma Open
View article: Socially Integrated Polysubstance (SIP) system: an open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice
Socially Integrated Polysubstance (SIP) system: an open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice Open
Despite impressive results from neuroscience research using rodent models, there is a paucity of successful translation from preclinical findings to effective pharmacological interventions for treatment of substance use disorder (SUD) in h…
View article: Timing matters: Sex differences in acute and chronic outcomes following repetitive blast mild traumatic brain injury
Timing matters: Sex differences in acute and chronic outcomes following repetitive blast mild traumatic brain injury Open
Background Repetitive blast-related mild traumatic brain injury (mTBI) caused by exposure to high explosives is increasingly common among warfighters as well as civilians. While women have been serving in military positions with increased …
View article: 0644 Longitudinal sleep instability contributes to cognitive decline and Alzheimer’s pathology: Findings from the Seattle Longitudinal Study
0644 Longitudinal sleep instability contributes to cognitive decline and Alzheimer’s pathology: Findings from the Seattle Longitudinal Study Open
Introduction Although emerging data suggest a link between sleep duration, aging, and dementia diagnosis, the impact of longitudinal patterns of sleep behavior on Alzheimer’s disease-associated pathology and cognitive decline remains uncle…
View article: Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice
Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice Open
Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways t…
View article: Repetitive Blast Exposure Increases Appetitive Motivation and Behavioral Inflexibility in Male Mice
Repetitive Blast Exposure Increases Appetitive Motivation and Behavioral Inflexibility in Male Mice Open
Blast exposure ( via detonation of high explosives) represents a major potential trauma source for Servicemembers and Veterans, often resulting in mild traumatic brain injury (mTBI). Executive dysfunction (e.g., alterations in memory, defi…
View article: Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans
Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans Open
Background Mild traumatic brain injury (mTBI) is common in civilians and highly prevalent among military service members. mTBI can increase health risk behaviors (e.g., sensation seeking, impulsivity) and addiction risk (e.g., for alcohol …
View article: Catecholaminergic Innervation of the Lateral Nucleus of the Cerebellum Modulates Cognitive Behaviors
Catecholaminergic Innervation of the Lateral Nucleus of the Cerebellum Modulates Cognitive Behaviors Open
The cerebellum processes neural signals related to rewarding and aversive stimuli, suggesting that the cerebellum supports nonmotor functions in cognitive and emotional domains. Catecholamines are a class of neuromodulatory neurotransmitte…
View article: Repetitive but not single blast mild traumatic brain injury increases ethanol responsivity in mice and risky drinking behavior in combat Veterans
Repetitive but not single blast mild traumatic brain injury increases ethanol responsivity in mice and risky drinking behavior in combat Veterans Open
Mild traumatic brain injury (mTBI) is common in civilians and highly prevalent among military Servicemembers and in contact sports athletes. mTBI, especially within military populations, is often comorbid with posttraumatic stress disorder…
View article: Repetitive Blast Promotes Chronic Aversion to Neutral Cues Encountered in the Peri-Blast Environment
Repetitive Blast Promotes Chronic Aversion to Neutral Cues Encountered in the Peri-Blast Environment Open
Repetitive mild traumatic brain injury (mTBI) has been called the "signature injury" of military service members in the Iraq and Afghanistan wars and is highly comorbid with post-traumatic stress disorder (PTSD). Correct attribution of adv…
View article: Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure
Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure Open
View article: Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury
Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury Open
View article: Repetitive blast promotes chronic aversion to neutral cues encountered in the peri-blast environment
Repetitive blast promotes chronic aversion to neutral cues encountered in the peri-blast environment Open
Repetitive mild traumatic brain injury (mTBI) has been called the “signature injury” of military Servicemembers in the Iraq and Afghanistan wars and is highly comorbid with posttraumatic stress disorder (PTSD). Correct attribution of adver…
View article: Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury
Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury Open
Blast-related mild traumatic brain injury (mTBI) is considered the "signature" injury of the wars in Iraq and Afghanistan. Identifying biomarkers that could aid in diagnosis and assessment of chronic mTBI are urgently needed, as little pro…