Abith Vattekkatte
YOU?
Author Swipe
View article: Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis and Chemistry
Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis and Chemistry Open
We report the first syntheses—from commercially available 3-chloro-2-fluoroprop-1-ene (9)—of key garlic-derived compounds containing sp2-fluorine. We also report synthesis of fluoro-5,6-dihydrothiopyrans by trapping 2-fluorothioacrolein (1…
View article: RETRACTED: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081
RETRACTED: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081 Open
The Journal retracts the article “Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies” [...]
View article: Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors
Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors Open
Terpenoids account for more than 60% of all natural products, and their carbon skeletons originate from common isoprenoid units of different lengths such as geranyl pyrophosphate and farnesyl pyrophosphate. Here we characterize a metal-dep…
View article: Correction: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081
Correction: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081 Open
In the original publication [...]
View article: Biosynthetic Origin of Complex Terpenoid Mixtures by Multiproduct Enzymes, Metal Cofactors, and Substrate Isomers
Biosynthetic Origin of Complex Terpenoid Mixtures by Multiproduct Enzymes, Metal Cofactors, and Substrate Isomers Open
Terpenoids form a substantial portion of chemical diversity in nature. The enormous terpenoid diversity of more than 80,000 compounds is supported by the multisubstrate and multiproduct nature of certain enzymes from the various terpene sy…
View article: Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors
Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors Open
Terpenoid structural diversity is enhanced by multiproduct enzymes. Biosynthesis can be altered by switch in substrates, cofactors and pH.
View article: RETRACTED: Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies
RETRACTED: Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies Open
We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin (S-(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S-2-fluoro-2-propenyl-l-cysteine, both easily prepared from commerciall…
View article: Trifluoroselenomethionine: A New Unnatural Amino Acid
Trifluoroselenomethionine: A New Unnatural Amino Acid Open
Trifluoroselenomethionine (TFSeM), a new unnatural amino acid, was synthesized in seven steps from N ‐( tert ‐butoxycarbonyl)‐ l ‐aspartic acid tert ‐butyl ester. TFSeM shows enhanced methioninase‐induced cytotoxicity, relative to selenome…
View article: Multiproduct terpene synthases: catalytic promiscuity and cyclization of substrate geometric isomers
Multiproduct terpene synthases: catalytic promiscuity and cyclization of substrate geometric isomers Open
Terpenes constitute the largest and the most diverse class of natural products. The wealth of terpenes can be attributed to highly promiscuous enzymes called terpene synthases. Apart from single product enzymes, there also exist multiprodu…