Abraham A. Palmer
YOU?
Author Swipe
View article: Ivermectin Reduces Withdrawal-Induced Alcohol Intake via CeA GABAergic Enhancement
Ivermectin Reduces Withdrawal-Induced Alcohol Intake via CeA GABAergic Enhancement Open
Although FDA-approved medications for alcohol use disorder (AUD) are available, their efficacy varies across patients, highlighting the need for novel therapeutics that address inter-individual differences in disease etiology and treatment…
View article: A Preclinical Alcohol Biobank: Samples from Behaviorally Characterized HS Rats for AUD Research
A Preclinical Alcohol Biobank: Samples from Behaviorally Characterized HS Rats for AUD Research Open
Alcohol use disorder (AUD) imposes a significant global health burden, yet effective treatments remain limited. There are no well-characterized, AUD-relevant, rodent biological sample repositories to support research in this area. To addre…
View article: Aberrant recursive splicing in a human disease locus
Aberrant recursive splicing in a human disease locus Open
Recursive splice sites are rare motifs postulated to facilitate splicing across massive introns and shape isoform diversity, especially for long, brain-expressed genes. The necessity of this unique mechanism remains unsubstantiated, as doe…
View article: Genome‐Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study
Genome‐Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study Open
Impulsivity, often operationalized as delay discounting (DD) and as impulsive personality traits via the UPPS‐P scales, is a key transdiagnostic construct across psychiatric disorders. Recent genome‐wide association studies (GWAS) have stu…
View article: Long Read Genome Sequencing Elucidates Diverse Functional Consequences of Structural and Repeat Variation in Autism
Long Read Genome Sequencing Elucidates Diverse Functional Consequences of Structural and Repeat Variation in Autism Open
Long read whole genome sequencing (LR WGS) technologies enhance the discovery of structural variants (SVs) and tandem repeats (TRs). Application of LR WGS has potential to identify novel risk factors that contribute to autism spectrum diso…
View article: Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats
Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats Open
Background Cocaine use disorder (CUD) is a major public health crisis with detrimental individual and societal effects. The specific genes mediating CUD remain largely unknown. Methods We conducted a genome-wide association study (GWAS) us…
View article: Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks
Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks Open
View article: Genomic structural equation study reveals links between anorexia nervosa and delay discounting and lack of perseverance but not other facets of impulsivity
Genomic structural equation study reveals links between anorexia nervosa and delay discounting and lack of perseverance but not other facets of impulsivity Open
Anorexia nervosa (AN) is a heritable condition, characterized by a fear of weight gain and a distorted body image, for which treatments are only limited. AN is characterized by excessive control over feeding behaviors, which has been hypot…
View article: Perinatal fentanyl exposure drives enduring addiction risk and central amygdala gene dysregulation
Perinatal fentanyl exposure drives enduring addiction risk and central amygdala gene dysregulation Open
The use of fentanyl and other opioids during pregnancy is a pressing public health issue due to its association with Neonatal Opioid Withdrawal Syndrome (NOWS) and long-term neurobehavioral deficits. Human epidemiologic studies are confoun…
View article: Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development
Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development Open
Background Impulsivity is a multifaceted transdiagnostic trait that emerges in childhood. Research has identified genetic loci and brain systems associated with different facets of impulsivity and risk-taking. However, how these genetic un…
View article: Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone.
Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone. Open
View article: Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation
Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation Open
The use of fentanyl and other opioids during pregnancy is a pressing public health issue due to its association with Neonatal Opioid Withdrawal Syndrome (NOWS) and long-term neurobehavioral deficits. Human epidemiologic studies are confoun…
View article: Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats
Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats Open
Opioid use disorder (OUD) is a major public health issue. Sleep and circadian disruptions are recognized as hallmarks of opioid addiction, often emerging during withdrawal and lasting into abstinence. However, little is known about the imp…
View article: Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts
Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts Open
A genetic liability toward externalizing is associated a wide array of behaviors and psychiatric/substance use outcomes beginning as early as childhood and through emerging adulthood. The early emergence and breadth of behaviors associated…
View article: RatXcan: A framework for cross-species integration of genome-wide association and gene expression data
RatXcan: A framework for cross-species integration of genome-wide association and gene expression data Open
Genome-wide association studies ( GWAS ) have implicated specific alleles and genes as risk factors for numerous complex traits. However, translating GWAS results into biologically and therapeutically meaningful discoveries remains extreme…
View article: Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study
Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study Open
Higher delay discounting (DD) (i.e., propensity to devalue larger, delayed rewards over immediate, smaller rewards) is a transdiagnostic marker underpinning multiple health behaviors. Although genetic influences account for some of the var…
View article: How it begins: Initial response to opioids strongly predicts self-reported opioid use disorder
How it begins: Initial response to opioids strongly predicts self-reported opioid use disorder Open
Background Opioid use disorder (OUD) is a major public health crisis. Patients' initial exposure to opioids often comes from prescribed medications. Predicting which of these patients will develop OUD remains challenging. Prior evidence fr…
View article: Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats
Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats Open
The intestinal microbiome influences health and disease. Its composition is affected by host genetics and environmental exposures. Understanding host genetic effects is critical but challenging in humans, due to the difficulty of detecting…
View article: High Incidence of Estrous Cycle Irregularities in Heterogeneous Stock (HS) Rats is Associated with Severe Cocaine Addiction-like Behaviors
High Incidence of Estrous Cycle Irregularities in Heterogeneous Stock (HS) Rats is Associated with Severe Cocaine Addiction-like Behaviors Open
Hormonal fluctuations throughout the estrous cycle have been hypothesized to influence drug-related behaviors. Preclinical models show that some cocaine-related behaviors are influenced by the estrous cycle. However, the extent to which th…
View article: Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats
Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats Open
Addiction vulnerability is associated with the tendency to attribute incentive salience to reward predictive cues. Both addiction and the attribution of incentive salience are influenced by environmental and genetic factors. To characteriz…
View article: Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament
Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament Open
Externalizing and internalizing behavioral tendencies underlie many psychiatric and substance use disorders. These tendencies are associated with differences in temperament that emerge early in development via the interplay of genetic and …
View article: Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains
Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains Open
Our results provide fundamental insight into the conserved molecular pathways altered by opioids across species, with evidence suggesting that alterations in females with OUD may be driven by drug exposure, while alterations in males with …
View article: Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats
Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats Open
View article: Delay discounting data in the Adolescent Brain Cognitive Development (ABCD) study: Modeling and analysis considerations.
Delay discounting data in the Adolescent Brain Cognitive Development (ABCD) study: Modeling and analysis considerations. Open
This report provides a primer to delay discounting data in the context of the Adolescent Brain Cognitive Development (ABCD) Study. Delay discounting describes the tendency for organisms to devalue temporally constrained outcomes. This deci…
View article: Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats
Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats Open
Rationale Opioid misuse is a prominent public health concern, although patterns of use may confer different vulnerability to relapse. Continuous-access ( ContA ) self-administration has traditionally been used in preclinical models to stud…
View article: Impulsivity facets and substance use involvement: insights from genomic structural equation modeling
Impulsivity facets and substance use involvement: insights from genomic structural equation modeling Open
Background Impulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of substance use involvement remains unclear. Methods We used genomic st…
View article: Investigating the Role of Glyoxalase 1 as a Therapeutic Target for Cocaine and Oxycodone Use Disorder
Investigating the Role of Glyoxalase 1 as a Therapeutic Target for Cocaine and Oxycodone Use Disorder Open
Methylglyoxal (MG) is an endogenously produced non-enzymatic side product of glycolysis that acts as a partial agonist at GABA A receptors. MG that is metabolized by the enzyme glyoxalase-1 (GLO1). Inhibition of GLO1 increases methylglyoxa…
View article: Genomic structural equation modeling of reward-related traits: exploring the genetic factor structure and its relationship with psychopathology
Genomic structural equation modeling of reward-related traits: exploring the genetic factor structure and its relationship with psychopathology Open
View article: A cost-effective, high-throughput, highly accurate genotyping method for outbred populations
A cost-effective, high-throughput, highly accurate genotyping method for outbred populations Open
Affordable sequencing and genotyping methods are essential for large-scale genome-wide association studies. While genotyping microarrays and reference panels for imputation are available for human subjects, nonhuman model systems often lac…
View article: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open