Anzalee Khan
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View article: Predicting Conversion From Laparoscopic to Open Cholecystectomy: A Prospective Risk Factor Analysis and Scoring Model Formulation
Predicting Conversion From Laparoscopic to Open Cholecystectomy: A Prospective Risk Factor Analysis and Scoring Model Formulation Open
Background Laparoscopic cholecystectomy (LC) is the gold standard treatment for symptomatic gallstone disease. However, a subset of cases requires conversion to open cholecystectomy (OC) due to anatomical challenges or intraoperative compl…
View article: Clozapine and the Voice Within: A Case of New-Onset Vocalizations and Obsessive Compulsive Symptoms
Clozapine and the Voice Within: A Case of New-Onset Vocalizations and Obsessive Compulsive Symptoms Open
Background: Treatment-resistant schizophrenia is the occurrence of delusions or hallucinations despite two antipsychotic drug attempts. Clozapine, an FDA-approved atypical antipsychotic, is reserved for such a case due to its efficacy but …
View article: The Impact of NIV on Hospital Duration in Pneumonia with Comorbid Heart Failure
The Impact of NIV on Hospital Duration in Pneumonia with Comorbid Heart Failure Open
Background: Pneumonia is still a key source of morbidity and mortality worldwide, particularly in patients with pre-existing heart failure. In addition, the coexistence of both diseases makes respiratory management more challenging and rec…
View article: A Comparative Evaluation of Peterson and Horvitz-Thompson Estimators for Population Size Estimation in Sparse Recapture Scenarios
A Comparative Evaluation of Peterson and Horvitz-Thompson Estimators for Population Size Estimation in Sparse Recapture Scenarios Open
Estimating population size is essential in ecological and social studies, particularly when direct enumeration is infeasible. This study compares the Peterson and Horvitz-Thompson estimators using capture-recapture data from female drivers…
View article: The conundrum of esophagogastric junction outflow obstruction: Answers to key clinical questions
The conundrum of esophagogastric junction outflow obstruction: Answers to key clinical questions Open
Esophagogastric junction outflow obstruction (EGJOO) is a heterogeneous disorder characterized by abnormal esophagogastric junction residual pressures in the setting of intact esophageal body peristalsis. This manometric finding is most cl…
View article: When Cancer Meets Crisis: Chronic Myeloid Leukemia, Severe Preeclampsia and a Surprise Ectopic Pregnancy in a Rare Multidisciplinary Case
When Cancer Meets Crisis: Chronic Myeloid Leukemia, Severe Preeclampsia and a Surprise Ectopic Pregnancy in a Rare Multidisciplinary Case Open
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the BCR-ABL1 fusion gene resulting from the t(9;22)(q34;q11) translocation. The advent of tyrosine kinase inhibitors (TKIs), particularly imatinib, has signif…
View article: Chorea hyperglycemia basal ganglia (CHBG) syndrome: A Case Report
Chorea hyperglycemia basal ganglia (CHBG) syndrome: A Case Report Open
Chorea, characterized by sudden, involuntary movements of the face and limbs, arises from various causes, including neurodegenerative diseases, metabolic disorders, and structural brain changes, notably in the basal ganglia. Acute lesions …
View article: Correlation of the VFSS Esophageal Screen to High‐Resolution Esophageal Manometry
Correlation of the VFSS Esophageal Screen to High‐Resolution Esophageal Manometry Open
Objective The videofluoroscopic swallow study (VFSS) is an evaluation of the anatomy and physiology of swallowing, and often includes a screening evaluation of the esophagus. How the esophageal screen translates to esophageal pathology rem…
View article: Game-Of-Goals: Using adversarial games to achieve strategic resilience
Game-Of-Goals: Using adversarial games to achieve strategic resilience Open
Our objective in this paper is to develop a machinery that makes a given organizational strategic plan resilient to the actions of competitor agents (adverse environmental actions). We assume that we are given a goal tree representing stra…
View article: Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial
Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial Open
Background Fabry disease is an X‐linked lysosomal storage disorder due to a deficiency of α‐galactosidase A (α‐gal A) activity. Our goal was to correct the enzyme deficiency in Fabry patients by transferring the cDNA for α‐gal A into their…
View article: Renal and multisystem effectiveness of 3.9 years of migalastat in a global real‐world cohort: Results from the <scp>followME</scp> Fabry <scp>Pathfinders</scp> registry
Renal and multisystem effectiveness of 3.9 years of migalastat in a global real‐world cohort: Results from the <span>followME</span> Fabry <span>Pathfinders</span> registry Open
Fabry disease is a progressive, X‐linked lysosomal disorder caused by reduced or absent α‐galactosidase A activity due to GLA variants. The effects of migalastat were examined in a cohort of 125 Fabry patients with migalastat‐amenable GLA …
View article: Identifying functional cortical plasticity after spinal tumour resection using navigated transcranial magnetic stimulation
Identifying functional cortical plasticity after spinal tumour resection using navigated transcranial magnetic stimulation Open
Our aim was to investigate the effectiveness of navigated transcranial magnetic stimulation (nTMS) brain mapping to characterise preoperative motor impairment caused by an intradural extramedullary (IDEM) tumour and postoperative cortical …
View article: Longitudinal biomarker evaluation in Fabry disease patients receiving lentivirus-mediated gene therapy
Longitudinal biomarker evaluation in Fabry disease patients receiving lentivirus-mediated gene therapy Open
Aim: In 2016, a team of Canadian researchers initiated the world’s first gene therapy clinical trial for Fabry disease. The study, aiming to determine the safety and toxicity of lentivirus α-galactosidase A transduced autologous CD34+ cell…
View article: P032: Decoding the genetic tapestry of long chain fatty acid oxidation disorders: Unveiling novel insights with a dynamic locus-specific gene database
P032: Decoding the genetic tapestry of long chain fatty acid oxidation disorders: Unveiling novel insights with a dynamic locus-specific gene database Open
Long-chain fatty acid oxidation disorders (LC-FAOD) are a group of six rare, life-threatening conditions typically detected through elevations in plasma acylcarnitine profiles, identified either through newborn screening (NBS) or by testin…
View article: A comparison of the efficacy of trastuzumab deruxtecan in advanced HER2-positive breast cancer: active brain metastasis versus progressive extracranial disease alone
A comparison of the efficacy of trastuzumab deruxtecan in advanced HER2-positive breast cancer: active brain metastasis versus progressive extracranial disease alone Open
In this real-world population, we demonstrate T-DXd to be effective in patients with active BMs and those with progressive extracranial disease alone. PFS and OS were numerically longer in those with active BMs. These data demonstrate that…
View article: Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT Open
The recognition that cytosolic mitochondrial DNA (mtDNA) activates cyclic GMP–AMP synthase-stimulator of interferon genes (cGAS-STING) innate immune signaling has unlocked novel disease mechanisms. Here, an uncharacterized variant predicte…