Abraham Rutgers
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View article: Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis
Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis Open
Objectives Nasal carriage of toxic shock syndrome toxin-1 (TSST-1)-positive Staphylococcus aureus (SA) is associated with a high relapse rate in granulomatosis with polyangiitis (GPA), suggesting TSST-1’s role in disease progression. This …
View article: Triggering trouble: post-translational modifications may drive myeloperoxidase autoimmunity
Triggering trouble: post-translational modifications may drive myeloperoxidase autoimmunity Open
View article: ABS0859 AZACITIDINE REDUCES SYMPTOMS AND UBA1 MUTATION VARIANT ALLELE FREQUENCY IN PATIENTS WITH VEXAS SYNDROME: A RETROSPECTIVE COHORT STUDY
ABS0859 AZACITIDINE REDUCES SYMPTOMS AND UBA1 MUTATION VARIANT ALLELE FREQUENCY IN PATIENTS WITH VEXAS SYNDROME: A RETROSPECTIVE COHORT STUDY Open
View article: POS1089 VEXAS syndrome as an underlying cause of disease in patients with Sweet syndrome
POS1089 VEXAS syndrome as an underlying cause of disease in patients with Sweet syndrome Open
View article: POS0861 BEYOND IgG: EXPLORING THE ADDITIVE VALUE OF ANTI-MPO IgM IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS (AAV)
POS0861 BEYOND IgG: EXPLORING THE ADDITIVE VALUE OF ANTI-MPO IgM IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS (AAV) Open
View article: Elevated Fab glycosylation of autoantibodies maintained during B cell depletion therapy
Elevated Fab glycosylation of autoantibodies maintained during B cell depletion therapy Open
View article: Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis Open
View article: Circulating B cells display differential immune regulatory molecule expression in granulomatosis with polyangiitis
Circulating B cells display differential immune regulatory molecule expression in granulomatosis with polyangiitis Open
Granulomatosis with polyangiitis (GPA) is a B-cell-mediated, relapsing, autoimmune disease. There is a need for novel therapeutic approaches and relapse markers to achieve durable remission. B cells express immune regulatory molecules that…
View article: (Levamisole Adulterated) Cocaine-Induced Vasculitis: What Is Known/Current Evidence
(Levamisole Adulterated) Cocaine-Induced Vasculitis: What Is Known/Current Evidence Open
Purpose of review (Levamisole adulterated) cocaine can cause a number of symptoms. One of the most severe is cocaine-induced vasculitis, which is hard to both diagnose and treat. We conducted a review to summarize the most recent findings …
View article: Baseline Blood CD8+ T Cell Activation Potency Discriminates Responders from Non-Responders to Immune Checkpoint Inhibition Combined with Stereotactic Radiotherapy in Non-Small-Cell Lung Cancer
Baseline Blood CD8+ T Cell Activation Potency Discriminates Responders from Non-Responders to Immune Checkpoint Inhibition Combined with Stereotactic Radiotherapy in Non-Small-Cell Lung Cancer Open
Background: Tumor-infiltrating immune cells have been correlated with prognosis for patients treated with immune checkpoint inhibitor (ICI) treatment of various cancers. However, no robust biomarker has been described to predict treatment …
View article: Real-world experience with targeted therapy in patients with histiocytic neoplasms in the Netherlands and in Belgium
Real-world experience with targeted therapy in patients with histiocytic neoplasms in the Netherlands and in Belgium Open
View article: Clinical and humoral response after SARS-CoV-2 breakthrough infection in patients receiving immunosuppressant therapy
Clinical and humoral response after SARS-CoV-2 breakthrough infection in patients receiving immunosuppressant therapy Open
View article: Comment on: Immune checkpoint inhibitor-mediated polymyalgia rheumatica versus primary polymyalgia rheumatica: comparison of disease characteristics and treatment requirement. Reply
Comment on: Immune checkpoint inhibitor-mediated polymyalgia rheumatica versus primary polymyalgia rheumatica: comparison of disease characteristics and treatment requirement. Reply Open
View article: Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity
Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity Open
Granulomatosis with polyangiitis (GPA) is an autoimmune disorder characterized by recurrent relapses that can cause severe tissue damage and life-threatening organ dysfunction. Multiple immune cells and cytokines/chemokines are involved in…
View article: Immunogenicity of COVID-19 booster vaccination in IEI patients and their one year clinical follow-up after start of the COVID-19 vaccination program
Immunogenicity of COVID-19 booster vaccination in IEI patients and their one year clinical follow-up after start of the COVID-19 vaccination program Open
Purpose Previous studies have demonstrated that the majority of patients with an inborn error of immunity (IEI) develop a spike (S)-specific IgG antibody and T-cell response after two doses of the mRNA-1273 COVID-19 vaccine, but little is …
View article: The link between the early surgery‐induced inflammatory response and postoperative cognitive dysfunction in older patients
The link between the early surgery‐induced inflammatory response and postoperative cognitive dysfunction in older patients Open
Background Postoperative cognitive dysfunction (POCD) is a common complication in older patients with cancer and is associated with decreased quality of life and increased disability and mortality rates. Systemic inflammation resulting in …
View article: mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses
mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses Open
SARS-CoV-2-specific CD8+ T cells recognize conserved viral peptides and in the absence of cross-reactive antibodies form an important line of protection against emerging viral variants as they ameliorate disease severity. SARS-C…
View article: Immune checkpoint inhibitor-mediated polymyalgia rheumatica versus primary polymyalgia rheumatica: comparison of disease characteristics and treatment requirement
Immune checkpoint inhibitor-mediated polymyalgia rheumatica versus primary polymyalgia rheumatica: comparison of disease characteristics and treatment requirement Open
Objectives To compare clinical characteristics, imaging findings and treatment requirements of patients with immune checkpoint inhibitor-mediated polymyalgia rheumatica (ICI-PMR) and primary PMR. Methods This single centre, retrospective c…
View article: Disease Activity after Sars-Cov-2 Delta and Omicron Breakthrough Infections in Patients with Immune-Mediated Inflammatory Diseases
Disease Activity after Sars-Cov-2 Delta and Omicron Breakthrough Infections in Patients with Immune-Mediated Inflammatory Diseases Open
View article: Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis Open
B lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cell subsets and beneficial clinical effects of rituximab (anti-CD20) therapy. This treatment renders a long-term, perip…
View article: Pleural Cryoglobulins
Pleural Cryoglobulins Open
A 63-year-old woman with a medical history of hepatitis C-negative mixed essential cryoglobulinemia presented with thoracic pain and dyspnea.Initial analysis showed no cardiac ischemia or pulmonary embolism.Bilateral pleural effusion devel…
View article: Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise
Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise Open
Introduction Immunoglobulin G (IgG) contains a conserved N-glycan in the fragment crystallizable (Fc), modulating its structure and effector functions. In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) alterations …
View article: Management of adult-onset Still's disease: evidence- and consensus-based recommendations by experts
Management of adult-onset Still's disease: evidence- and consensus-based recommendations by experts Open
Objectives Adult-onset Still’s disease (AOSD) is a rare condition characterized by fevers, rash, and arthralgia/arthritis; most doctors treating AOSD in the Netherlands treat <5 patients per year. Currently, there is no internationally …
View article: Neurological phenotype of adenosine deaminase 2 deficient patients: a cohort study
Neurological phenotype of adenosine deaminase 2 deficient patients: a cohort study Open
Background and purpose Patients with adenosine deaminase 2 (ADA2) deficiency can present with various neurological manifestations due to vasculopathies and autoinflammation. These include ischaemic and hemorrhagic stroke, but less clearly …
View article: Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort
Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort Open
Deficiency of adenosine deaminase-2 (DADA2) is an autosomal recessive autoinflammatory disease with an extremely variable disease presentation. This paper provides a comprehensive overview of the Dutch DADA2 cohort. We performed a retrospe…
View article: POS0100 TARGETING NF-ΚB SIGNALLING IN B LINEAGE CELLS AS A POTENTIAL NOVEL TREATMENT STRATEGY FOR ANCA-ASSOCIATED VASCULITIS
POS0100 TARGETING NF-ΚB SIGNALLING IN B LINEAGE CELLS AS A POTENTIAL NOVEL TREATMENT STRATEGY FOR ANCA-ASSOCIATED VASCULITIS Open
View article: Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunity
Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunity Open
View article: Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity
Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity Open
View article: Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with granulomatosis with polyangiitis
Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with granulomatosis with polyangiitis Open
Objectives Granulomatosis with polyangiitis (GPA) is a chronic relapsing systemic autoimmune vasculitis. Current treatment of GPA is unsatisfactory, as it relies on strong immunosuppressive regimens, with either CYC or rituximab, which red…
View article: Persistence of seroconversion at 6 months following primary immunisation in patients with immune-mediated inflammatory diseases
Persistence of seroconversion at 6 months following primary immunisation in patients with immune-mediated inflammatory diseases Open