Explanipedia

Comparative effectiveness of standalone middle meningeal artery embolization versus surgical evacuation in noncritical patients with nonacute subdural hematomas Open

Ignacio Mesina-Estarrón, Jose A. Plascencia-Jimenez, Nanthiya Sujijantarat, Adam A. Dmytriw, Varun Padmanaban , et al. · 2025

OBJECTIVE Middle meningeal artery embolization (MMAE) has emerged as an alternative to surgical treatment of nonacute subdural hematoma (NASDH). When used in conjunction with surgery, it has been shown to reduce recurrence, but its effecti…

7 Tesla Time-of-Flight MRA in Adolescents Open

Sergio Valencia, Fedel Machado‐Rivas, María Camila Cortés-Albornoz, Samuel Cartmell, Harry Griffin , et al. · 2025

CR＝ Contrast Ratio; LSA＝ Lenticulostriate Perforating Arteries.

Endovascular therapeutic occlusion of major cerebral arteries in children Open

Kittiphop Somboonnithiphol, Soliman Oushy, Alfred P. See, Darren B. Orbach · 2025

Background Therapeutic occlusion of major cerebral arteries is sometimes required in pediatric cerebrovascular conditions of the head and neck. However, this procedure carries a considerable risk of stroke and de novo intracranial aneurysm…

Employing large language models safely and effectively as a practicing neurosurgeon Open

Advait Patil, Paul Serrato, Gracie Cleaver, Daniela Limbania, Alfred P. See , et al. · 2025

Detection of GFAP and D‐Dimer in a Point‐of‐Care Test for Large Vessel Occlusion Ischemic Stroke Open

Edoardo Gaude, Danielle Murphy, Jakob V. E. Gerstl, Ari D. Kappel, Adam A. Dmytriw , et al. · 2025

Background The blood biomarkers GFAP (glial fibrillary acidic protein) and D‐dimer have been shown to accurately diagnose large vessel occlusion ischemic stroke. The Upfront DX LVOne is a novel lateral flow‐based point‐of‐care test used fo…

Long‐Term Hemorrhagic Morbidity for Children With Moyamoya Treated With Revascularization Surgery in a Single Center Retrospective Cohort Open

Alfred P. See, Sophia D. Kocher, Paulina Piwowarczyk, Sanda Alexandrescu, Keith L. Ligon , et al. · 2024

Background Children with moyamoya arteriopathy have reduced subsequent ischemic risk after revascularization surgery and it is also suggested that hemorrhagic risk may also be reduced by minimizing hemodynamic stress on collateral vasculat…

Comparison of nBCA and Onyx for Embolization of Spinal Dural Arteriovenous Fistulas Open

Jacob F. Baranoski, Joshua S. Catapano, Caleb Rutledge, Tyler S. Cole, Neil Majmundar , et al. · 2024

Background Endovascular embolization can effectively treat spinal dural arteriovenous fistulas (SDAVFs). One factor limiting the success and durability of endovascular treatments is reliably casting and occluding the draining vein. We soug…

Comparing Vascular Morphology and Hemodynamics in Patients with Vein of Galen Malformations Using Intracranial 4D Flow MRI Open

Jeffrey N. Stout, Alfred P. See, Julie Meadows, Shivani D. Rangwala, Darren B. Orbach · 2024

Using 4D flow MRI, we established the hemodynamic underpinnings of the mediolateral diameter of the straight or falcine sinus and investigated metrics representing parenchymal venous drainage that could be used to monitor the normalization…

A Review of the Current State and Future Directions for Management of Scalp and Facial Vascular Malformations Open

Eric R. Hartman, Daniel M. Balkin, Alfred P. See · 2024

Vascular malformations are structural abnormalities that are thought to result from errors in vasculogenesis and angiogenesis during embryogenesis. Vascular malformations of the scalp present unique management challenges due to aesthetic a…

Endovascular Applications for the Management of High-Grade Gliomas in the Modern Era Open

Ari D. Kappel, Rohan Jha, Saibaba Guggilapu, W. J. Bernhard Smith, Abdullah Feroze , et al. · 2024

High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for …

Management of Pediatric Intracranial Arteriovenous Malformations Open

Alfred P. See, Edward R. Smith · 2024

Pediatric intracranial arteriovenous malformations (AVMs) are challenging lesions managed by pediatric neurosurgeons. The high risk of hemorrhage and neurologic injury is compounded by the unique anatomy of each malformation that requires …

Referral of Pediatric Moyamoya for Revascularization: Financial and Quality Data Supporting Private Insurer Approval for Out‐of‐Network Care Open

Shivani D. Rangwala, Nikita Singh, Jennifer Judge, Christopher Isibor, Craig D. McClain , et al. · 2024

Background Moyamoya is a rare arteriopathy affecting the intracranial circulation with a risk of stroke in the pediatric population. High‐volume centers provide improved outcomes after surgical revascularization compared with low‐volume ce…

Rupture risk and outcomes of giant aneurysms in pediatric patients: a multi-institutional case series and systematic review Open

Saksham Gupta, Blake M. Hauser, Joshua S. Catapano, Dara S. Farhadi, Patrick R. Ng , et al. · 2023

OBJECTIVE Giant aneurysms in pediatric patients are vascular lesions that can cause significant neurological morbidity and mortality. Their rarity has precluded large cohort studies to inform their management. The objective of this study w…

Index for Volume 143 (2023) Open

O Vieira, J. Fuchs, Philip D. Round, Trinidad Manuel Góngora García, Alfred P. See , et al. · 2023

Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations Open

Shujuan Zhao, Kedous Y. Mekbib, Martijn A. van der Ent, Garrett Allington, Andrew Prendergast , et al. · 2023

Middle meningeal artery embolization for refractory chronic subdural hematoma in a pediatric victim of nonaccidental trauma: illustrative case Open

Zsombor Gal, Alfred P. See · 2023

BACKGROUND Chronic subdural hematoma (cSDH) in children is associated with several etiologies, one of which is nonaccidental trauma (NAT). Performed alone or as an adjunct to surgical intervention, middle meningeal artery (MMA) embolizatio…

Focal drug-resistant temporal lobe epilepsy associated with an ipsilateral anterior choroidal artery aneurysm: illustrative case Open

H. Westley Phillips, Shivani D. Rangwala, Joanna E. Papadakis, David J. Segar, Melissa Tsuboyama , et al. · 2023

BACKGROUND The occurrence of both an intracranial aneurysm and epilepsy, especially drug-resistant epilepsy (DRE), is rare. Although the overall incidence of aneurysms associated with DRE is unclear, it is thought to be particularly infreq…

Cerebrovascular reserve in moyamoya requires more standardization: editorial on ASL-MRI guided evaluation of multiple burr hole revascularization surgery in moyamoya disease Open

Alfred P. See, Jeffrey N. Stout · 2023

Understanding development of jugular bulb stenosis in vein of galen malformations: identifying metrics of complex flow dynamics in the cerebral venous vasculature of infants Open

Sara Hadad, Shivani D. Rangwala, Jeffrey N. Stout, Fernando Mut, Darren B. Orbach , et al. · 2023

Introduction: Computational fluid dynamics (CFD) assess biological systems based on specific boundary conditions. We propose modeling more advanced hemodynamic metrics, such as core line length (CL) and critical points which characterize c…

Transuterine Ultrasound-Guided Fetal Embolization of Vein of Galen Malformation, Eliminating Postnatal Pathophysiology Open

Darren B. Orbach, Louise Wilkins‐Haug, Carol B. Benson, Wayne Tworetzky, Shivani D. Rangwala , et al. · 2023

espite decades of technique refinement of transarterial embolization and the establishment of specialty referral centers, fetuses diagnosed with vein of Galen malformation continue to have high mortality, with survivors facing high rates o…

SUMOtherapeutics for Ischemic Stroke Open

Paramesh Karandikar, Jakob V. E. Gerstl, Ari D. Kappel, Sae‐Yeon Won, Daniel Dubinski , et al. · 2023

The small, ubiquitin-like modifier (SUMO) is a post-translational modifier with a profound influence on several key biological processes, including the mammalian stress response. Of particular interest are its neuroprotective effects, firs…

SUMOtherapeutics for Ischemic Stroke Open

Paramesh Karandikar, Jakob V. E. Gerstl, Ari D. Kappel, Sae‐Yeon Won, Daniel Dubinski , et al. · 2023

Small, Ubiquitin-like Modifier (SUMO) is a post-translational modifier with a profound influence on several key biological processes including the mammalian stress response. Of particular interest is its neuroprotective effects, first reco…

Data from Immunologic Consequences of Signal Transducers and Activators of Transcription 3 Activation in Human Squamous Cell Carcinoma Open