Abujunaid Habib Khan
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View article: S9 Protease WprP Catalyzes Uniform and Sequential Cleavage on the Precursor Peptide in RiPP Biosynthesis
S9 Protease WprP Catalyzes Uniform and Sequential Cleavage on the Precursor Peptide in RiPP Biosynthesis Open
Serine proteases in ribosomally synthesized and post-translationally modified peptides (RiPPs) catalyze the cleavage on the precursor peptides in the biosynthesis of RiPP natural products. Here, we identified an uncharacterized serine prot…
View article: Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024
Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024 Open
Macrocyclic compounds have emerged in the 21st century, among which cyclic peptides are of particular interest. Cyanobactins are ribosomally synthesized and post-translationally modified peptides (RiPPs), many of which exist as cyclic pept…
View article: P450 Biarylitide Synthase ShyB Catalyzes the Cross-Link Between His-C2 and Tyr-O4 on the Precursor Peptide
P450 Biarylitide Synthase ShyB Catalyzes the Cross-Link Between His-C2 and Tyr-O4 on the Precursor Peptide Open
Biarylitides are a new class of ribosomally synthesized and post-translationally modified peptides (RiPPs) with the unique feature of biaryl C-C, C-N, or C-O cross-links installed by P450 biarylitide synthases (P450s). Here, we manually id…
View article: Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs
Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs Open
Cyclophane-containing products from ribosomally synthesized and post-translationally modified peptides (RiPPs) are generated by radical SAM cyclophane synthases (rSAM). In the past few years, rSAM enzymes that catalyze uniform cyclophanes …
View article: Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide
Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide Open
Cross-link containing products from ribosomally synthesized and post-translationally modified peptides (RiPPs) are generated by radical SAM enzymes (rSAM). Here, we bioinformatically expanded rSAM enzymes based on the known families StrB, …
View article: P450 cyptide synthase MpoB catalyzes the cross-linking of the YPW motif on the precursor peptide
P450 cyptide synthase MpoB catalyzes the cross-linking of the YPW motif on the precursor peptide Open
The uncharacterized cytochrome P450 cyptide synthase MpoB from Micromonospora polyrhachis DSM 45886 catalyzes a cross-link between Tyr-C3 and Trp-N1 at the YPW motif on the precursor peptide MpoA.
View article: <i>In vitro</i> anticancer evaluation of Enceleamycin A and its underlying mechanism
<i>In vitro</i> anticancer evaluation of Enceleamycin A and its underlying mechanism Open
Enceleamycin A a candidate molecule for treating TNBC cells by targeting the AKT2 signaling pathway.
View article: CCDC 1946291: Experimental Crystal Structure Determination
CCDC 1946291: Experimental Crystal Structure Determination Open
View article: CCDC 1946293: Experimental Crystal Structure Determination
CCDC 1946293: Experimental Crystal Structure Determination Open
View article: Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials
Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials Open
The first total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate (butenolide cinnamate) was achieved using commercially available starting material. The synthesized compound was found to have promising antibacterial activity against Gra…
View article: Approach to nigericin derivatives and their therapeutic potential
Approach to nigericin derivatives and their therapeutic potential Open
A new nigericin analogue that has been chemically modified was synthesized through a fluorination process from the parent nigericin, produced from a novel Streptomyces strain DASNCL-29.