Abul Bashar Mohammed Helaluddin
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View article: Anti-obesity and antihyperlipidemic effects of Phaleria macrocarpa fruit liquid CO2 extract: In vitro, in silico and in vivo approaches
Anti-obesity and antihyperlipidemic effects of Phaleria macrocarpa fruit liquid CO2 extract: In vitro, in silico and in vivo approaches Open
Objective: Phaleria macrocarpa fruit has been reported to be effectively used in Malaysia and neighboring countries to prevent obesity. Despite its anti-obesity potential, no research has ever predicted the compound-lipase, compound-HMG-Co…
View article: In Vitro, In Silico and Network Pharmacology Mechanistic Approach to Investigate the α-Glucosidase Inhibitors Identified by Q-ToF-LCMS from Phaleria macrocarpa Fruit Subcritical CO2 Extract
In Vitro, In Silico and Network Pharmacology Mechanistic Approach to Investigate the α-Glucosidase Inhibitors Identified by Q-ToF-LCMS from Phaleria macrocarpa Fruit Subcritical CO2 Extract Open
The fruit of Phaleria macrocarpa have been traditionally used as an antidiabetic remedy in Malaysia and neighbouring countries. Despite its potential for diabetes treatment, no scientific study has ever been conducted to predict the inhibi…
View article: Acute and subacute toxicity assessment of liquid CO2 extract of Phaleria macrocarpa fruits flesh in mice model
Acute and subacute toxicity assessment of liquid CO2 extract of Phaleria macrocarpa fruits flesh in mice model Open
Objectives: Phaleria macrocarpa (Scheff.) Boerl., an evergreen tree is found in Indonesia, Malaysia and Oceania, explicitly Northern Territory of Australia and Papua New Guinea. The fruits are traditionally used to treat various ailments i…
View article: Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology
Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology Open
The purpose of current research work was to formulate and typify gelatin and poly(vinyl) alcohol (Gel/PVA) hydrogel which would be highly pH-responsive and can able to accomplish targeted delivery of methotrexate in order to treat the colo…
View article: Quantitation of Pregabalin by HPLC-UV Method using Ninhydrin Derivatization: Development and Validation
Quantitation of Pregabalin by HPLC-UV Method using Ninhydrin Derivatization: Development and Validation Open
Introduction: A simple and reliable high performance liquid chromatographic method has been developed for the quantitative determination of pregabalin in bulk and dosage form. Pregabalin, a γ amino butyric acid analogue, has negligible sen…
View article: Preliminary Study on the Formulation of Syariah Compliant Generic Sustained Release Gliclazide Tablet Using Xanthan Gum
Preliminary Study on the Formulation of Syariah Compliant Generic Sustained Release Gliclazide Tablet Using Xanthan Gum Open
Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sus…
View article: Development and validation of LC-MSMS method for the analysis of amlodipine and perindopril in tablet dosage form
Development and validation of LC-MSMS method for the analysis of amlodipine and perindopril in tablet dosage form Open
Introduction: Amlodipine (AMLO) and Perindopril (PER) have
\nbeen combined in one tablet dosage form which has been
\nproven to be an effective and well tolerated antihypertensive.
\nMany analytical methods were applied for the analysis…
View article: In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds
In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds Open
We have aimed to evaluate the in vitro cytotoxic and in vivo anxiolytic and sedative activities of the methanolic extract of Sterculia villosa roxb seeds. The dried powder of the seeds was extracted with methanol which was then tested to a…
View article: Influence of inorganic stabilizers on releasing volatile (As and Hg) metal ions from complex matrices of natural medicinal products in spectroscopic elemental analysis
Influence of inorganic stabilizers on releasing volatile (As and Hg) metal ions from complex matrices of natural medicinal products in spectroscopic elemental analysis Open
Arsenic (As) and mercury (Hg) are hazardous elements that occurs at trace amounts in various samples including natural medicinal products (NMPs). The consumption of the contaminated products leads to adverse health consequences. Regular mo…
View article: Evaluation of graphite furnace and hydride generation atomic absorption spectrometry for trace analysis of arsenic in natural herbal medicine
Evaluation of graphite furnace and hydride generation atomic absorption spectrometry for trace analysis of arsenic in natural herbal medicine Open
Introduction: Arsenic is a hazardous element that occurs in trace amounts in various environmental samples including natural products. The growing demand of such products for medical purposes imposes their safety and efficacy. Hydride gene…
View article: Bio-analytical method for generic formulation: an IIUM pharmaceutical manufacturing plant experience
Bio-analytical method for generic formulation: an IIUM pharmaceutical manufacturing plant experience Open
Generic formulation of pharmaceutical dosage forms are emerging since the regulation of generic production of out of patent drug was implemented worldwide. Malaysian drug control authority has implemented policies to promote generic produc…
View article: Effect of different digestion techniques on elements recoveries for spectroscopic analysis in natural medicinal remedies
Effect of different digestion techniques on elements recoveries for spectroscopic analysis in natural medicinal remedies Open
Natural products have great importance in various medical applications worldwide. Safety and efficacy issues are vital for insuring public health and long-term success of such products. The existence of potentially toxic metals such as ars…
View article: Development and validation of bioanalytical method for amlodipine in human plasma with optimised extraction method using Design of Experiment (DOE)
Development and validation of bioanalytical method for amlodipine in human plasma with optimised extraction method using Design of Experiment (DOE) Open
Amlodipine is antihypertensive drug belonging to calcium antagonist group. This study aims to apply experimental design for the optimization of extraction method of amlodipine from human plasma for higher and constant recovery. A chromatog…