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View article: Penile cancer and lymph node management: a call for standardization
Penile cancer and lymph node management: a call for standardization Open
Purpose This study aims to compare and organize recommendations from the most eminent international guidelines on the staging and treatment of lymph node (LN) involvement in penile cancer (PC). Early recognition and appropriate management …
View article: Enhanced prognostic value of four‐tier hybrid grading system in Ta non‐muscle‐invasive bladder cancer
Enhanced prognostic value of four‐tier hybrid grading system in Ta non‐muscle‐invasive bladder cancer Open
Objectives To compare the predictive performance of the World Health Organization (WHO) 1973, WHO 2004/2022, the three‐tier (low grade [LG]/Grade 1 [G1]–G2, high grade [HG]/G2, and HG/G3), and four‐tier (LG/G1, LG/G2, HG/G2, and HG/G3) hyb…
View article: Rare case of urinary tract infection caused by Cedecea lapagei in a 93-year-old patient in southern Italy
Rare case of urinary tract infection caused by Cedecea lapagei in a 93-year-old patient in southern Italy Open
Cedecea lapagei is a rare Gram-negative bacterium that has been infrequently associated with human infections. It is a non-encapsulated, facultative anaerobic organism that grows well in nonselective laboratory media and exhibits variable …
View article: Prostate Artery Embolization (PAE) in the Treatment of Benign Prostatic Hyperplasia: A Case Series and Narrative Review
Prostate Artery Embolization (PAE) in the Treatment of Benign Prostatic Hyperplasia: A Case Series and Narrative Review Open
Background/Objectives: Prostatic artery embolization (PAE) has emerged as a minimally invasive alternative for treating lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), particularly in high-risk surgical…
View article: The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy
The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy Open
Cancer stem cells (CSCs) are a subpopulation with self-renewal and differentiation capacities believed to be responsible for tumor initiation, progression, and recurrence. These cells exhibit unique metabolic features that contribute to th…
View article: Advancing Surgical Management of Penile Cancer: Single Port Bilateral Inguinal Lymph Node Dissection
Advancing Surgical Management of Penile Cancer: Single Port Bilateral Inguinal Lymph Node Dissection Open
Introduction: Penile cancer is a rare but aggressive malignancy, with inguinal lymph node involvement representing a key prognostic indicator (1, 2). NCCN guidelines recommend prophylactic inguinal lymph node dissection (ILND) for intermed…
View article: Preoperative platelet-to-lymphocyte ratio as a predictor of inguinal lymph node metastasis in penile cancer
Preoperative platelet-to-lymphocyte ratio as a predictor of inguinal lymph node metastasis in penile cancer Open
Background: Penile cancer (PC) is a rare malignancy with poor prognosis. To date, reliable preoperative biomarkers for lymph node status and prognosis are still lacking. This study aims to explore the potential role of preoperative platele…
View article: The evolving landscape of renal surgery for complex renal masses (CRM): implications for oncologic and functional outcomes
The evolving landscape of renal surgery for complex renal masses (CRM): implications for oncologic and functional outcomes Open
Partial nephrectomy (PN) has become the standard of treatment for most T1 renal masses and is suitable for selected T2 renal cortical masses. In this setting, the management of complex renal masses (CRM) requires a thorough understanding o…
View article: Implementation and early outcomes of Da Vinci SP® Robot-Assisted partial nephrectomy via supine anterior retroperitoneal access: Italian single centre experience
Implementation and early outcomes of Da Vinci SP® Robot-Assisted partial nephrectomy via supine anterior retroperitoneal access: Italian single centre experience Open
Single-port RAPN with the da Vinci SP® system is safe and feasible, with promising short-term outcomes.
View article: Insights into Porphyromonas somerae in Bladder Cancer Patients: Urinary Detection by ddPCR
Insights into Porphyromonas somerae in Bladder Cancer Patients: Urinary Detection by ddPCR Open
To date, the increased awareness of the impact of microbes on human health has promoted scientific interest in microbiome studies for diagnostic and therapeutic purposes, revealing correlations between specific taxa and cancer. In particul…
View article: Predictive medicine in a testis trio‐family through a combined multi‐omics approach
Predictive medicine in a testis trio‐family through a combined multi‐omics approach Open
Dear Editor, This study takes a comprehensive approach that combines targeted gene panel sequencing, whole genome sequencing (WGS), and DNA methylation analysis of a family trio with a history of seminoma and other tumours, in an attempt t…
View article: Testicular Cancer Treatments and Sexuality: A Narrative Review
Testicular Cancer Treatments and Sexuality: A Narrative Review Open
The incidence of testicular cancer (TC) has been rapidly increasing over the past years. Diagnosis and early treatment have shown good oncological control, guaranteeing the patient different treatment approaches according to histology and …
View article: Ablative Treatments for Small Renal Masses and Management of Recurrences: A Comprehensive Review
Ablative Treatments for Small Renal Masses and Management of Recurrences: A Comprehensive Review Open
This review focuses on ablative techniques for small renal masses (SRMs), including radiofrequency ablation (RFA), cryoablation (CA), microwave ablation (MWA), and irreversible electroporation (IRE), and discusses recurrence management. Th…
View article: Upper Tract Urothelial Cancer: Guideline of Guidelines
Upper Tract Urothelial Cancer: Guideline of Guidelines Open
Background: Upper tract urothelial carcinoma (UTUC) is a rare disease with a potentially dismal prognosis. We systematically compared international guidelines on UTUC to analyze similitudes and differences among them. Methods: We conducted…
View article: Outcomes and Techniques of Robotic-Assisted Partial Nephrectomy (RAPN) for Renal Hilar Masses: A Comprehensive Systematic Review
Outcomes and Techniques of Robotic-Assisted Partial Nephrectomy (RAPN) for Renal Hilar Masses: A Comprehensive Systematic Review Open
Background: Robot-assisted partial nephrectomy (RAPN) is increasingly being employed in the management of renal cell carcinoma (RCC) and it is expanding in the field of complex renal tumors. The aim of this systematic review was to consoli…
View article: Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives
Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives Open
Urinary tract infections (UTIs) are the second most frequent type of infection observed in clinical practice. Gram-negative Enterobacteriaceae are common pathogens in UTIs. Excessive antibiotic use in humans and animals, poor infection con…
View article: Review of: "Breaking Stereotypes: Sectoral Varicocele Diagnosis Revolutionized by Doppler Ultrasound Advancements"
Review of: "Breaking Stereotypes: Sectoral Varicocele Diagnosis Revolutionized by Doppler Ultrasound Advancements" Open
Potential competing interests: No potential competing interests to declare.This study investigated the accuracy of Doppler ultrasound (DUS) for varicocele diagnosis compared to the standard physical exam.I believe that the study has suffic…
View article: Is Systemic Immune-Inflammation Index a Real Non-Invasive Biomarker to Predict Oncological Outcomes in Patients Eligible for Radical Cystectomy?
Is Systemic Immune-Inflammation Index a Real Non-Invasive Biomarker to Predict Oncological Outcomes in Patients Eligible for Radical Cystectomy? Open
Background and Objectives: To assess the potential prognostic role of the systemic immune-inflammation index (SII) in predicting oncological outcomes in a cohort of patients treated with radical cystectomy (RC). Materials and Methods: From…
View article: The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives
The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives Open
Background and Objectives: Despite advancements in the diagnosis and treatment of testicular germ cell tumours (TGTCs), challenges persist in identifying reliable biomarkers for early detection and precise disease management. This narrativ…
View article: Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review
Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review Open
MicroRNAs (miRNAs) are emerging as biomarkers for the detection and prognosis of cancers due to their inherent stability and resilience. To summarize the evidence regarding the role of urinary miRNAs (umiRNAs) in the detection, prognosis, …
View article: Robot-assisted radical prostatectomy: comparison of subarachnoid analgesia, erector spine plane block, and intravenous analgesia for postoperative pain management
Robot-assisted radical prostatectomy: comparison of subarachnoid analgesia, erector spine plane block, and intravenous analgesia for postoperative pain management Open
Subarachnoid analgesia is an effective strategy to manage postoperative pain in robot-assisted radical prostatectomy; it allows to reduce both intraoperative and postoperative opioid consumption and the amount of inhalation anesthetics com…
View article: Urinary Micro-RNAs As Biomarkers of Urological Cancers: A Systematic Review
Urinary Micro-RNAs As Biomarkers of Urological Cancers: A Systematic Review Open
Background: Micro-RNAs (miRNA) are emerging as biomarkers in the detection and prognosis of cancers due to their inherent stability and resilience. Methods: To summarize evidence regarding urinary miRNA (umiRNAs) role in the detection, pro…
View article: The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial
The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial Open
Introduction: Bacterial prostatitis (BP) is a common prostatic infection characterized by a bimodal distribution in young and older men, with a prevalence between 5–10% among all cases of prostatitis and a high impact on quality of life. A…
View article: A Novel Low-Cost Uroflowmetry for Patient Telemonitoring
A Novel Low-Cost Uroflowmetry for Patient Telemonitoring Open
Uroflowmetry (UF) is a crucial guideline-recommended tool for men with benign prostatic obstruction (BPO). Moreover, UF is a helpful decision-making tool for the management of patients with lower urinary tract symptoms (LUTS) and benign pr…
View article: 8-Hydroxy-2-Deoxyguanosine and 8-Iso-Prostaglandin F2α: Putative Biomarkers to assess Oxidative Stress Damage Following Robot-Assisted Radical Prostatectomy (RARP)
8-Hydroxy-2-Deoxyguanosine and 8-Iso-Prostaglandin F2α: Putative Biomarkers to assess Oxidative Stress Damage Following Robot-Assisted Radical Prostatectomy (RARP) Open
Objective: Prostate cancer (PCa) is the most common type of cancer. Biomarkers help researchers to understand the mechanisms of disease and refine diagnostic panels. We measured urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-iso-prostag…
View article: The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk?
The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? Open
Bladder cancer (BC) represents the second most common genitourinary malignancy. The major risk factors for BC include age, gender, smoking, occupational exposure, and infections. The BC etiology and pathogenesis have not been fully defined…