Explanipedia

TNF Superfamily Member 14 Drives Post-Influenza Depletion of Alveolar Macrophages Enabling Secondary Pneumococcal Pneumonia Open

Christina Malainou, Christin Peteranderl, Maximiliano Ruben Ferrero, Ana Ivonne Vazquez‐Armendariz, Ioannis Alexopoulos , et al. · 2025

Secondary bacterial infection, often caused by Streptococcus pneumoniae (Spn), is one of the most frequent and severe complications of influenza A virus (IAV)-induced pneumonia. Phenotyping of the pulmonary immune cell landscape after IAV …

Spillover infections by rustrela virus, borna disease virus 1 and tick-borne encephalitis virus revealed by retrospective screening of mammalian encephalitis of unknown origin Open

Anne Voß, Anne Günther, Olga Geit, Karin Stiasny, Achim D. Gruber , et al. · 2025

Background Cross-species transmission of several viral neuropathogens may lead to fatal disease in incidental hosts. The newly discovered rustrela virus (RusV) as well as Borna disease virus 1 (BoDV-1), tick-borne encephalitis virus (TBEV)…

Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury Open

Sarah Berger, Cengiz Goekeri, Peter Pennitz, Birgitt Gutbier, Laura Michalick , et al. · 2025

Acute lung injury is a common complication of pneumonia, with disease severity linked to inflammatory cell recruitment and lung barrier dysfunction. In this study, we investigate the role of neutrophil-chemoattractant CXCL5 in lung barrier…

Overventilation-induced airspace acidification increases susceptibility to Pseudomonas pneumonia Open

Matthias Felten, Chunjiang Tan, Sebastian Ferencik, Jingjing Li, Eleftheria Letsiou , et al. · 2025

Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in critically ill patients. Local pH variations affect bacterial growth. This study investigated the role and mechanisms of airspace acidification by mechanica…

Strong correlation of gene counts and differentially expressed genes between a 3′ RNA-Seq and an RNA hybridization platform in transcriptome analyses from canine archival tissues Open

Alexander Haake, Alina K. Loriani Fard, Vladimir Jovanović, Sandro Andreotti, Achim D. Gruber · 2025

Analyses of nucleic acids from archival tissues offer invaluable prospects for numerous fields of veterinary medicine, such as the study of differential gene expression in rare or historic diseases. The establishment of modern methodologie…

Differential expression of host invasion-associated genes by Sarcocystis calchasi in intermediate versus definitive hosts Open

Kristina Maier-Sam, Oliver Rupp, Anne Voß, Saskia Nemitz, Tassilo Erik Wollenweber , et al. · 2025

Sarcocystis calchasi is a pathogenic apicomplexan parasite affecting avian species of several orders. To complete its heteroxenous life cycle, S. calchasi infects a wide range of avian intermediate hosts and accipitriform raptors serve as …

EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder Open

Cleo Schwarz, Florian Bartenschlager, Olivia Kershaw, Judith Braun, Julien Guevar , et al. · 2025

Background Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. Objective The objective of this work was to document th…

The impact of disease and species differences on the intestinal CLCA4 gene expression Open

K Teske, Nancy A. Erickson, Amelia Huck, Maria Dzamukova, Marcus Fulde , et al. · 2025

The human chloride channel regulator, calcium-activated (CLCA) 4 is discussed as a driver of epithelial-to-mesenchymal transition as well as a biomarker for colorectal cancer (CRC) and ulcerative colitis. In contrast to humans, the Clca4 g…

Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury Open

Sarah Berger, Cengiz Goekeri, Peter Pennitz, Birgitt Gutbier, Laura Michalick , et al. · 2024

Rationale Acute lung injury is frequently caused by pneumonia, and severity correlates with inflammatory cell recruitment and lung barrier failure. Deciphering drug-targetable pathways is of clinical importance. Objectives Investigation of…

Immuno-oncologic profiling by stage-dependent transcriptome and proteome analyses of spontaneously regressing canine cutaneous histiocytoma Open

Alina K. Loriani Fard, Alexander Haake, Vladimir Jovanović, Sandro Andreotti, Michael Hummel , et al. · 2024

Canine cutaneous histiocytoma (CCH) is a tumor that originates from dermal Langerhans cells and affects particularly young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Previ…

Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus Open

Diana Fatykhova, Verena Nadin Fritsch, Keerthana Siebert, Karen Methling, Michael Lalk , et al. · 2024

Streptococcus pneumoniae is the most common causative agent of community-acquired pneumonia worldwide. A key pathogenic mechanism that exacerbates severity of disease is the disruption of the alveolar–capillary barrier. However, the specif…

Overventilation-induced airspace acidification increases susceptibility to Pseudomonas pneumonia Open

Matthias Felten, Chunjiang Tan, Sebastian Ferencik, Jinɡjinɡ Li, Eleftheria Letsiou , et al. · 2024

Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in critically ill patients. Local pH variations affect bacterial growth. Whether airway acidification contributes to the pathogenesis and pathophysiology of Ps…

TNF Superfamily Member 14 Drives Post-Influenza Depletion of Alveolar Macrophages Enabling Secondary Pneumococcal Pneumonia Open

Christina Malainou, Christin Peteranderl, Maximiliano Ruben Ferrero, Ana Ivonne Vazquez‐Armendariz, Ioannis Alexopoulos , et al. · 2024

Secondary bacterial infection, often caused by Streptococcus pneumoniae (Spn), is one of the most frequent and severe complications of influenza A virus (IAV)-induced pneumonia. Phenotyping of the pulmonary innate immune landscape after IA…

Enzymatic Modulation of the Pulmonary Glycocalyx Enhances Susceptibility to Streptococcus pneumoniae Open

Cengiz Goekeri, K. Linke, Karen Hoffmann, Elena López-Rodríguez, Vladimir Gluhovic , et al. · 2024

The pulmonary epithelial glycocalyx is rich in glycosaminoglycans such as hyaluronan and heparan sulfate. Despite their presence, the importance of these glycosaminoglycans in bacterial lung infections remains elusive. To address this, we …

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19 Open

Stefan Peidli, Geraldine Nouailles, Emanuel Wyler, Julia M. Adler, Sandra Kunder , et al. · 2024

A key issue for research on COVID-19 pathogenesis is the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be useful models for studying this disease. Here, we furthe…

An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission Open

Julia M. Adler, Ricardo Martin Vidal, Christine Langner, Daria Vladimirova, Azza Abdelgawad , et al. · 2024

The development of effective SARS-CoV-2 vaccines has been essential to control COVID-19, but significant challenges remain. One problem is intramuscular administration, which does not induce robust mucosal immune responses in the upper air…

Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters Open

Luiz Gustavo Teixeira Alves, Morris Baumgardt, Christine Langner, Mara Fischer, Julia M. Adler , et al. · 2024

Introduction The emergence of new SARS-CoV-2 variants, capable of escaping the humoral immunity acquired by the available vaccines, together with waning immunity and vaccine hesitancy, challenges the efficacy of the vaccination strategy in…

Enzymatic modulation of the pulmonary glycocalyx alters susceptibility toStreptococcus pneumoniae Open

Cengiz Goekeri, K. Linke, Karen Hoffmann, Elena López-Rodríguez, Vladimir Gluhovic , et al. · 2024

The pulmonary epithelial glycocalyx is rich in glycosaminoglycans such as hyaluronan and heparan sulfate. Despite their presence, the precise role of these glycosaminoglycans in bacterial lung infections remains elusive. To address this, w…

Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice Open

Tanya Dogra, Lars Pelz, Julia D. Boehme, Jan Kuechler, Olivia Kershaw , et al. · 2023

Correction: State-of-the-art analytical methods of viral infections in human lung organoids Open

Morris Baumgardt, Maren Hülsemann, Anna Löwa, Diana Fatykhova, Karen Hoffmann , et al. · 2023

[This corrects the article DOI: 10.1371/journal.pone.0276115.].

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19 Open

Stefan Peidli, Geraldine Nouailles, Emanuel Wyler, Julia M. Adler, Sandra Kunder , et al. · 2023

Key issues for research of COVID-19 pathogenesis are the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be useful models for studying this disease. Here, we furthe…

Generation of “OP7 chimera” defective interfering particle preparations free of infectious influenza A virus that shows antiviral efficacy in mice Open

Tanya Dogra, Lars Pelz, Julia D. Boehme, Jan Küchler, Olivia Kershaw , et al. · 2023

Influenza A virus (IAV) defective interfering particles (DIPs) are considered as new promising antiviral agents. Conventional DIPs (cDIPs) contain a deletion in the genome and can only replicate upon co-infection with infectious standard v…

Early protective effect of a (“pan”) coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration Open

Mohammed Abdelaziz, Martin Raftery, Julian Weihs, Olivia Bielawski, Richard Edel , et al. · 2023

Introduction The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the danger posed by human coronaviruses. Rapid emergence of immunoevasive variants and wan…

A non-transmissible live attenuated SARS-CoV-2 vaccine Open

Julia M. Adler, Ricardo Martin Vidal, Anne Voß, Sandra Kunder, Mariana Nascimento , et al. · 2023

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters Open

Geraldine Nouailles, Julia M. Adler, Peter Pennitz, Stefan Peidli, Luiz Gustavo Teixeira Alves , et al. · 2023

Supplementary Figures 1 - 4 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open