Achim Lass
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Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon <span> CCl <sub>4</sub> </span> ‐Induced Liver Injury Open
Background and Aims Advanced liver disease leads to liver fibrosis that is characterised by the activation of non‐parenchymal stellate cells, accumulation of extracellular matrix proteins, and the loss of hepatic vitamin A stores. To date,…
Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols Open
In mammalian cells, glycerolipids are mainly synthesized using acyl-CoA-dependent mechanisms. The acyl-CoA-independent transfer of fatty acids between lipids, designated as transacylation reaction, represents an additional mechanism for li…
View article: The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extracellular pathways
The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extracellular pathways Open
Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation and sorting of lipid cargo. Recent observations suggest that the Batten disea…
View article: Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice
Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice Open
Background Accumulation of amyloid beta (Aβ) and tau proteins have for decades been thought to be central in the pathogenesis of Alzheimer’s disease (AD). More recently, a plethora of evidence emerged that links metabolic dysfunctions such…
View article: Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation Open
Defective degradation and clearance of amyloid-β as well as inflammation per se are crucial players in the pathology of Alzheimer's disease (AD). A defective transport across the blood-brain barrier is causative for amyloid-β (Aβ) accumula…
ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions Open
The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol ac…
KIAA1363—A Multifunctional Enzyme in Xenobiotic Detoxification and Lipid Ester Hydrolysis Open
KIAA1363, annotated as neutral cholesterol ester hydrolase 1 (NCEH1), is a member of the arylacetamide deacetylase (AADAC) protein family. The name-giving enzyme, AADAC, is known to hydrolyze amide and ester bonds of a number of xenobiotic…
Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes Open
Chronically elevated circulating fatty acid levels promote lipid accumulation in nonadipose tissues and cause lipotoxicity. Adipose triglyceride lipase (ATGL) critically determines the release of fatty acids from white adipose tissue, and …
Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease Open
Retinol binding protein 4 (RBP4) is the specific transport protein of the lipophilic vitamin A, retinol, in blood. Circulating RBP4 originates from the liver. It is secreted by hepatocytes after it has been loaded with retinol and binding …
Biological Functions of RBP4 and Its Relevance for Human Diseases Open
Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation. Expression of RBP4 is highest in the liver, where most o…
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity Open
Objective In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) acts as a lipid sensor that regulates hepatic lipid catabolism during fasting and orchestrates a genomic response required for whole-body homeostasis. This incl…
Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation Open
Vitamin A is stored as retinyl esters (REs) in lipid droplets of hepatic stellate cells (HSCs). To date, two different pathways are known to facilitate the breakdown of REs: (i) Hydrolysis of REs by neutral lipases, and (ii) whole lipid dr…
MOESM4 of Comparative transcriptomics reveals candidate carotenoid color genes in an East African cichlid fish Open
Additional file 4. Supplementary information on the qPCR experiment: Candidate reference genes selected based on RNA-Seq data; qPCR primers for candidate reference and target genes; Cq and RQ values of target genes; paired t-tests for dors…
MOESM2 of Comparative transcriptomics reveals candidate carotenoid color genes in an East African cichlid fish Open
Additional file 2: Table S1. Differentially expressed genes identified in the RNA-Seq experiment.
Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation Open
Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses wit…
Abnormal composition and function of high‐density lipoproteins in atopic dermatitis patients Open
High-density lipoprotein (HDL) is conserved and present in most species, suggesting an important biological role from an evolutionary standpoint. HDL suppresses the activation of immune cells,1 including eosinophils.2 Despite the evidence …