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View article: DNA abasic sites act as rational therapeutic targets to synergize temozolomide response in both MMR-proficient and deficient cancer
DNA abasic sites act as rational therapeutic targets to synergize temozolomide response in both MMR-proficient and deficient cancer Open
Temozolomide (TMZ) is widely used in cancer treatment, yet resistance to this agent limits its therapeutic effectiveness, particularly in mismatch-repair (MMR) deficient cancer. Concurrently, the Base Excision Repair (BER) pathway exerts a…
View article: Conductance Switching in Liquid Crystal-Inspired Self-Assembled Monolayer Junctions
Conductance Switching in Liquid Crystal-Inspired Self-Assembled Monolayer Junctions Open
We present the prototype of a ferroelectric tunnel junction (FTJ), which is based on a self-assembled monolayer (SAM) of small, functional molecules. These molecules have a structure similar to those of liquid crystals, and they are embedd…
View article: Cleavage of Abasic Sites in DNA by an Aminoquinoxaline Compound: Augmented Cytotoxicity and DNA Damage in Combination with an Anticancer Drug Chlorambucil in Human Colorectal Carcinoma Cells
Cleavage of Abasic Sites in DNA by an Aminoquinoxaline Compound: Augmented Cytotoxicity and DNA Damage in Combination with an Anticancer Drug Chlorambucil in Human Colorectal Carcinoma Cells Open
The elevated level of endogenous oxidative DNA damage and spontaneous deamination of DNA bases in cancer cells substantially increase the abasic sites in DNA via base excision repairs (BERs). Thus, the predominant BER pathway is a favorabl…
View article: High-yield metal transfer printing on alkyl bis-phosphonate monolayers
High-yield metal transfer printing on alkyl bis-phosphonate monolayers Open
The successful transfer printing of thin metal films onto monolayers of aliphatic bisphosphonic acids (bisPAs) is reported. These monolayers were prepared from solution on plasma-grown aluminum oxide, and were compared with analogous monol…