Steven J. Ackerman
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View article: Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus
Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus Open
Human sialic acid-binding immunoglobulin-like lectins (Siglecs) are expressed on subsets of immune cells. Siglec-8 is an immune inhibitory Siglec on eosinophils and mast cells, which are effectors in allergic disorders including eosinophil…
View article: Considerations on the evolutionary biology and functions of eosinophils: what the “haeckel”?
Considerations on the evolutionary biology and functions of eosinophils: what the “haeckel”? Open
The origins and evolution of the eosinophilic leukocyte have received only scattered attention since Paul Ehrlich first named this granulocyte. Studies suggest that myeloperoxidase, expressed by granulocytes, and eosinophil peroxidase dive…
View article: Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities
Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities Open
Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis, and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood a…
View article: Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model
Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model Open
The role of SPHK1-specific inhibitor, PF543, in preventing goblet cell metaplasia (GCM) and airway hyperreactivity (AHR) is established in an allergen-induced mouse model. This protection was associated with the downregulation of NOTCH2-SP…
View article: CX<sub>3</sub>CR<sub>1</sub><sup>+</sup> Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26
CX<sub>3</sub>CR<sub>1</sub><sup>+</sup> Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26 Open
Rationale: The resolution of inflammation is an active process coordinated by mediators and immune cells to restore tissue homeostasis. However, the mechanisms for resolving eosinophilic allergic lung inflammation triggered by inhaled alle…
View article: In Reply—Are Eosinophils Needed for Normal Health?
In Reply—Are Eosinophils Needed for Normal Health? Open
We thank Drs Gleich and Leiferman for their letter in response to our state-of- the-art review on eosinophils in health and disease.1Wechsler M.E. Munitz A. Ackerman S.J. et al.Eosinophils in health and disease: a state-of-the-art review.M…
View article: CCAAT/Enhancer-Binding Protein ε27 Antagonism of GATA-1 Transcriptional Activity in the Eosinophil Is Mediated by a Unique N-Terminal Repression Domain, Is Independent of Sumoylation and Does Not Require DNA Binding
CCAAT/Enhancer-Binding Protein ε27 Antagonism of GATA-1 Transcriptional Activity in the Eosinophil Is Mediated by a Unique N-Terminal Repression Domain, Is Independent of Sumoylation and Does Not Require DNA Binding Open
CCAAT/enhancer binding protein epsilon (C/EBPε) is required for eosinophil differentiation, lineage-specific gene transcription, and expression of C/EBPε32 and shorter 27kD and 14kD isoforms is developmentally regulated during this process…
View article: Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development
Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development Open
Regulation of the IL-5 receptor alpha (IL5RA) gene is complicated, with two known promoters (P1 and P2) driving transcription, and two known isoforms (transmembrane and soluble) dichotomously affecting the signaling potential of the protei…
View article: Eosinophils in Health and Disease: A State-of-the-Art Review
Eosinophils in Health and Disease: A State-of-the-Art Review Open
Eosinophils play a homeostatic role in the body's immune responses. These cells are involved in combating some parasitic, bacterial, and viral infections and certain cancers and have pathologic roles in diseases including asthma, chronic r…
View article: Noninvasive biomarkers identify eosinophilic esophagitis: A prospective longitudinal study in children
Noninvasive biomarkers identify eosinophilic esophagitis: A prospective longitudinal study in children Open
Background Esophageal histology is critical for diagnosis and surveillance of disease activity in eosinophilic esophagitis (EoE). A validated noninvasive biomarker has not been identified. We aimed to determine the utility of blood and uri…
View article: Noninvasive Biomarkers Identify Eosinophilic Esophagitis: A Prospective Longitudinal Study in Children
Noninvasive Biomarkers Identify Eosinophilic Esophagitis: A Prospective Longitudinal Study in Children Open
Background: Esophageal histology is critical for diagnosis and surveillance of disease activity in eosinophilic esophagitis (EoE). A validated noninvasive biomarker has not been identified. We aimed to determine the utility of blood and ur…
View article: Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia Open
Hyperoxia (HO)-induced lung injury contributes to bronchopulmonary dysplasia (BPD) in preterm newborns. Intractable wheezing seen in BPD survivors is associated with airway remodeling (AWRM). Sphingosine kinase 1 (SPHK1)/sphingosine-1-phos…
View article: Contributions of Eosinophils to Human Health and Disease
Contributions of Eosinophils to Human Health and Disease Open
The human eosinophil has long been thought to favorably influence innate mucosal immunity but at times has also been incriminated in disease pathophysiology. Research into eosinophil biology has uncovered a number of interesting contributi…
View article: One-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis
One-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis Open
OBJECTIVES: Eosinophilic esophagitis (EoE), a chronic food allergic disease, lacks sensitive and specific peripheral biomarkers. We hypothesized that levels of EoE-related biomarkers captured using a 1-hour minimally invasive Esophageal St…
View article: Colony‐stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma
Colony‐stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma Open
Background A new approach targeting aeroallergen sensing in the early events of mucosal immunity could have greater benefit. The CSF1‐CSF1R pathway has a critical role in trafficking allergens to regional lymph nodes through activating den…
View article: Charcot–Leyden Crystal Protein/Galectin-10 Is A Surrogate Biomarker of Eosinophilic Airway Inflammation in Asthma
Charcot–Leyden Crystal Protein/Galectin-10 Is A Surrogate Biomarker of Eosinophilic Airway Inflammation in Asthma Open
Aim: Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & …
View article: Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)
Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD) Open
Eosinophil-associated diseases (EADs) are rare, heterogeneous disorders characterized by the presence of eosinophils in tissues and/or peripheral blood resulting in immunopathology. The heterogeneity of tissue involvement, lack of sufficie…
View article: Polyunsaturated Lysophosphatidic Acid as a Potential Asthma Biomarker
Polyunsaturated Lysophosphatidic Acid as a Potential Asthma Biomarker Open
Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. Total LPA levels are increased in bronchoalveolar lavage fluid fro…
View article: Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases Open
Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we re…
View article: Esophageal Microbiome in Eosinophilic Esophagitis
Esophageal Microbiome in Eosinophilic Esophagitis Open
Diseases associated with mucosal eosinophilia are characterized by a different microbiome from that found in the normal mucosa. Microbiota may contribute to esophageal inflammation in EoE and GERD.