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View article: SARS-CoV-2 Entry Can Be Mimicked in C. elegans Expressing Human ACE2: A New Tool for Pharmacological Studies
SARS-CoV-2 Entry Can Be Mimicked in C. elegans Expressing Human ACE2: A New Tool for Pharmacological Studies Open
Testing medical countermeasures for SARS-CoV-2 transmission using vertebrates can be hindered by legislation regulating animal experimentation, high costs, and ethical concerns. To overcome these challenges, we propose a new Caenorhabditis…
View article: SARS-CoV-2 Entry Can Be Mimicked in <em>C. elegans</em> Expressing Human ACE2: A New Tool for Pharmacological Studies
SARS-CoV-2 Entry Can Be Mimicked in <em>C. elegans</em> Expressing Human ACE2: A New Tool for Pharmacological Studies Open
Testing medical countermeasures for SARS-CoV-2 transmission using vertebrates can be slowed by legislation regulating animal experimentation, high costs, and ethical concerns. To overcome these challenges, we propose a new Caenorhabditis e…
View article: Xanthohumol destabilizes the structure of amyloid-β (Aβ) oligomers and promotes the formation of high-molecular-weight amorphous aggregates
Xanthohumol destabilizes the structure of amyloid-β (Aβ) oligomers and promotes the formation of high-molecular-weight amorphous aggregates Open
This study provides a comprehensive structural analysis of prenylflavonoids (PFs) interaction with Aβ1-42 oligomers, revealing their potential to modulate amyloid peptide aggregation pathways. Among the tested PFs, xanthohumol (XN), isoxan…
View article: Clay-dye fluorescent hybrid material for the detection of neurotransmitter secretion from cells
Clay-dye fluorescent hybrid material for the detection of neurotransmitter secretion from cells Open
We present a clay-dye hybrid material (MDAP@MMT) for the rapid and selective fluorescence-based detection of catecholamine neurotransmitters.
View article: Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs
Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs Open
Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the ta…
View article: The antipsychotic drug lurasidone inhibits coronaviruses by affecting multiple targets
The antipsychotic drug lurasidone inhibits coronaviruses by affecting multiple targets Open
Coronaviruses (CoVs) share key genomic elements critical for viral replication, suggesting the feasibility of developing therapeutics with efficacy across different viruses. In a previous work, we demonstrated the antiviral activity of the…
View article: Melanoma Extracellular Vesicles Membrane Coated Nanoparticles as Targeted Delivery Carriers for Tumor and Lungs
Melanoma Extracellular Vesicles Membrane Coated Nanoparticles as Targeted Delivery Carriers for Tumor and Lungs Open
View article: Assessing the physicochemical stability and intracellular trafficking of mRNA-based COVID-19 vaccines
Assessing the physicochemical stability and intracellular trafficking of mRNA-based COVID-19 vaccines Open
View article: A Comprehensive Technology Platform for the Rapid Discovery of Peptide Inhibitors against SARS-CoV-2 Pseudovirus Infection
A Comprehensive Technology Platform for the Rapid Discovery of Peptide Inhibitors against SARS-CoV-2 Pseudovirus Infection Open
We developed and validated a technology platform for designing and testing peptides inhibiting the infectivity of SARS-CoV-2 spike protein-based pseudoviruses. This platform integrates target evaluation, in silico inhibitor design, peptide…
View article: Aβ1-6A2V(D) peptide, effective on Aβ aggregation, inhibits tau misfolding and protects the brain after traumatic brain injury
Aβ1-6A2V(D) peptide, effective on Aβ aggregation, inhibits tau misfolding and protects the brain after traumatic brain injury Open
View article: Alzheimer's Disease Prevention through Natural Compounds: Cell- Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity
Alzheimer's Disease Prevention through Natural Compounds: Cell- Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity Open
The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer’s disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natu…
View article: Alzheimer’s Disease Prevention through Natural Compounds: Cell-Free<i>, In Vitro</i>, and <i>In Vivo</i> Dissection of Hop (<i>Humulus lupulus</i> L.) Multitarget Activity
Alzheimer’s Disease Prevention through Natural Compounds: Cell-Free<i>, In Vitro</i>, and <i>In Vivo</i> Dissection of Hop (<i>Humulus lupulus</i> L.) Multitarget Activity Open
The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natu…
View article: A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo
A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo Open
A clear relationship between the tau assemblies and toxicity has still to be established. To correlate the tau conformation with its proteotoxic effect in vivo, we developed an innovative cell-worm-based approach. HEK293 cells expressing t…
View article: A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo
A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo Open
A clear relationship between the tau assemblies and toxicity has still to be established. To correlate the tau conformation with its proteotoxic effect in vivo, we developed an innovative cell-worm-based approach. HEK293 cells expressing t…
View article: A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers in Vivo
A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers in Vivo Open
A clear relationship between the tau assemblies and toxicity has still to be established. To correlate the tau conformation with its proteotoxic effect in vivo we developed an innovative cell-worm-based approach. HEK293 cells expressing ta…
View article: NMR-Driven Identification of Cinnamon Bud and Bark Components With Anti-Aβ Activity
NMR-Driven Identification of Cinnamon Bud and Bark Components With Anti-Aβ Activity Open
The anti-Alzheimer disease (AD) activity reported for an aqueous cinnamon bark extract prompted us to investigate and compare the anti-amyloidogenic properties of cinnamon extracts obtained from both bark and bud, the latter being a very l…
View article: Biochemical and biophysical features of disease-associated tau mutants V363A and V363I
Biochemical and biophysical features of disease-associated tau mutants V363A and V363I Open
The comprehension of pathogenetic mechanisms in tauopathy-associated neurodegenerative diseases can be improved by the knowledge of the biochemical and biophysical features of mutated tau proteins. Here, we used the full-length, wild-type …
View article: Biochemical and biophysical features of disease-associated tau mutants V363A and V363I
Biochemical and biophysical features of disease-associated tau mutants V363A and V363I Open
View article: Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity
Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity Open
The rapid spread of the pandemic caused by the SARS-CoV-2 virus has created an unusual situation, with rapid searches for compounds to interfere with the biological processes exploited by the virus. Doxycycline, with its pleiotropic effect…
View article: Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivity
Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivity Open
The pandemic caused by the SARS-CoV-2 has created the need of compounds able to interfere with the biological processes exploited by the virus. Doxycycline, with its pleiotropic effects, including anti-viral activity, has been proposed as …
View article: Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis
Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis Open
The release of neutrophil extracellular traps (NETs), a process termed NETosis, avoids pathogen spread but may cause tissue injury. NETs have been found in severe COVID-19 patients, but their role in disease development is still unknown. T…
View article: Dataset related to article. "Nonphosphorylated tau slows down Aβ1–42 aggregation, binds to Aβ1–42 oligomers, and reduces Aβ1–42 toxicity"
Dataset related to article. "Nonphosphorylated tau slows down Aβ1–42 aggregation, binds to Aβ1–42 oligomers, and reduces Aβ1–42 toxicity" Open
Figures presented in the paper and their data can be found in the corresponding prism files (www.graphpad.com). The raw data and the picture files for most of the figures can be found in the folder with the corresponding figure name.
View article: Dataset related to article. "Nonphosphorylated tau slows down Aβ1–42 aggregation, binds to Aβ1–42 oligomers, and reduces Aβ1–42 toxicity"
Dataset related to article. "Nonphosphorylated tau slows down Aβ1–42 aggregation, binds to Aβ1–42 oligomers, and reduces Aβ1–42 toxicity" Open
Figures presented in the paper and their data can be found in the corresponding prism files (www.graphpad.com). The raw data and the picture files for most of the figures can be found in the folder with the corresponding figure name.
View article: Nonphosphorylated tau slows down Aβ1–42 aggregation, binds to Aβ1–42 oligomers, and reduces Aβ1–42 toxicity
Nonphosphorylated tau slows down Aβ1–42 aggregation, binds to Aβ1–42 oligomers, and reduces Aβ1–42 toxicity Open
The formation of neurofibrillary tangles and amyloid plaques accompanies the progression of Alzheimer's disease. Tangles are made of fibrillar aggregates formed by the microtubule-associated protein tau, whereas plaques comprise fibrillar …
View article: Neutrophil extracellular traps induce the epithelial-mesenchymal transition: implications in post-COVID-19 fibrosis
Neutrophil extracellular traps induce the epithelial-mesenchymal transition: implications in post-COVID-19 fibrosis Open
The release of neutrophil extracellular traps (NETs), a process termed NETosis, avoids pathogen spread but may cause tissue injury. NETs have been found in severe COVID-19 patients, but their role in disease development is still unknown. T…
View article: NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts
NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts Open
View article: Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study
Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study Open
Due to their altered metabolism cancer cells are more sensitive to proteasome inhibition or changes of copper levels than normal cells. Thus, the development of copper complexes endowed with proteasome inhibition features has emerged as a …
View article: Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib
Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib Open
The activation of Nrf2 has been demonstrated to play a crucial role in cancer cell resistance to different anticancer therapies. The inhibition of proteasome activity has been proposed as a chemosensitizing therapy but the activation of Nr…
View article: Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria
Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria Open
A new paradigm for the aetiopathology of phenylketonuria suggests the presence of amyloid-like assemblies in the brains of transgenic mouse models and patients with phenylketonuria, possibly shedding light on the selective cognitive defici…