Adam Aissanou
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View article: TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer
TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer Open
In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…
View article: Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors
Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors Open
Human topoisomerase IIβ binding protein 1 (TopBP1) is a scaffold protein involved in DNA replication initiation, DNA repair, transcription regulation, and checkpoint activation. TopBP1 forms nuclear condensates that act as a molecular swit…
View article: TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer
TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer Open
In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…
View article: TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer
TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer Open
In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…
View article: TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer
TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer Open
In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…
View article: TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer
TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer Open
In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…
View article: Immunogenic Treatment for Metastatic Breast Cancer Using Targeted Carbon Nanotube Mediated Photothermal Therapy in Combination with Anti-PD-1
Immunogenic Treatment for Metastatic Breast Cancer Using Targeted Carbon Nanotube Mediated Photothermal Therapy in Combination with Anti-PD-1 Open
The high prevalence of breast cancer is a global health concern, but there are no safe or effective treatments for it at its advanced stages. These facts urge the development of novel treatment strategies. Annexin A5 (ANXA5) is a natural h…