Explanipedia

An actomyosin-mediated mechanical mechanism for brain neural tube elevation Open

J. O, Gabriel L. Galea, Adam C. Martin · 2025

Embryos fold their tissues into increasingly complicated shapes during development. Cells produce and coordinate the forces needed to fold tissues through networks of F-actin and Myosin II (actomyosin). We can discern the mechanical mechan…

Actomyosin contraction in the follicular epithelium provides the major mechanical force for follicle rupture during Drosophila ovulation Open

Stella E. Cho, Wei Li, Andrew M. Beard, Jonathan A. Jackson, Risa Kiernan , et al. · 2024

Ovulation is critical for sexual reproduction and consists of the process of liberating fertilizable oocytes from their somatic follicle capsules, also known as follicle rupture. The mechanical force for oocyte expulsion is largely unknown…

Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila Open

Jonathan A. Jackson, Marlis Denk-Lobnig, Katherine A. Kitzinger, Adam C. Martin · 2024

Morphogenesis: Setting the pace of embryo folding Open

D. Nathaniel Clarke, Adam C. Martin · 2024

Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination Open

Uzuki Horo, D. Nathaniel Clarke, Adam C. Martin · 2024

The regulation of the cytoskeleton by multiple signaling pathways, sometimes in parallel, is a common principle of morphogenesis. A classic example of regulation by parallel pathways is Drosophila gastrulation, where the inputs from the Fo…

DrosophilaFog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination Open

Uzuki Horo, D. Nathaniel Clarke, Adam C. Martin · 2024

The regulation of the cytoskeleton by multiple pathways, sometimes in parallel, is a common principle of morphogenesis. A classic example of regulation by parallel pathways is Drosophila gastrulation, where the inputs from the Folded gastr…

EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues Open

D. Nathaniel Clarke, Adam C. Martin · 2023

The movements that give rise to the body’s structure are powered by cell shape changes and rearrangements that are coordinated at supracellular scales. How such cellular coordination arises and integrates different morphogenetic programs i…

The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis Open

Isabella Burda, Adam C. Martin, Adrienne Roeder, Mary Collins · 2023

Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability inDrosophila Open

Jonathan A. Jackson, Marlis Denk-Lobnig, Katherine A. Kitzinger, Adam C. Martin · 2023

Summary Actin cortex patterning and dynamics are critical for cell shape changes. These dynamics undergo transitions during development, often accompanying changes in collective cell behavior. While mechanisms have been established for ind…

Scaling behaviour and control of nuclear wrinkling Open

Jonathan A. Jackson, Nicolas Romeo, Alexander Mietke, Keaton J. Burns, Jan Frederik Totz , et al. · 2023

Topological packing statistics of living and nonliving matter Open

Dominic J. Skinner, Hannah Jeckel, Adam C. Martin, Knut Drescher, Jörn Dunkel · 2023

Complex disordered matter is of central importance to a wide range of disciplines, from bacterial colonies and embryonic tissues in biology to foams and granular media in materials science to stellar configurations in astrophysics. Because…

Topological packing statistics of living and non-living matter Open

Dominic J. Skinner, Hannah Jeckel, Adam C. Martin, Knut Drescher, Jörn Dunkel · 2023

This repository contains the data and code needed to recreate figures in the main and supplementary text of the paper "Topological packing statistics of living and non-living matter" by the same authors. Instructions for running the code a…

Topological packing statistics of living and non-living matter Open

Dominic J. Skinner, Hannah Jeckel, Adam C. Martin, Knut Drescher, Jörn Dunkel · 2023

This repository contains the data and code needed to recreate figures in the main and supplementary text of the paper "Topological packing statistics of living and non-living matter" by the same authors. Instructions for running the code a…

Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development Open

Anna R.A Yeh, Gregory J. Hoeprich, Bruce L. Goode, Bruce L. Goode, Adam C. Martin · 2023

Actin networks undergo rearrangements that influence cell and tissue shape. Actin network assembly and organization is regulated in space and time by a host of actin binding proteins. The Drosophila Synaptotagmin-like protein, Bitesize (Bt…

Scaling behaviour and control of nuclear wrinkles Open

Jonathan A. Jackson, Nicolas Romeo, Alexandeer Mietke, Jan Frederik Totz, Keaton J. Burns , et al. · 2023

This repository contains some of the data presented in the article 'Scaling behaviour and control of nuclear wrinkles' by the same authors in Nature Physics (2023). For more details on the methods, see the accompanying manuscript.plotData_…

Live Imaging of Nurse Cell Behavior in Late Stages of Drosophila Oogenesis Open

Jonathan A. Jackson, Jasmin Imran Alsous, Adam C. Martin · 2023

Dynamics, scaling behavior, and control of nuclear wrinkling Open

Jonathan A. Jackson, Nicolas Romeo, Alexander Mietke, Keaton J. Burns, Jan Frederik Totz , et al. · 2022

The cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling during multicellular development remain poorly und…

Topological packing statistics distinguish living and non-living matter Open

Dominic J. Skinner, Hannah Jeckel, Adam C. Martin, Knut Drescher, Jörn Dunkel · 2022

How much structural information is needed to distinguish living from non-living systems? Here, we show that the statistical properties of Delaunay tessellations suffice to differentiate prokaryotic and eukaroytic cell packings from a wide …

Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation Open

Jaclyn Camuglia, Soline Chanet, Adam C. Martin · 2022

Spindle orientation is often achieved by a complex of Partner of Inscuteable (Pins)/LGN, Mushroom Body Defect (Mud)/Nuclear Mitotic Apparatus (NuMa), Gαi, and Dynein, which interacts with astral microtubules to rotate the spindle. Cortical…

Author response: Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation Open

Jaclyn Camuglia, Soline Chanet, Adam C. Martin · 2022

Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation Open

Jaclyn Camuglia, Soline Chanet, Adam C. Martin · 2022

Spindle orientation is often achieved by a complex of Pins/LGN, Mud/NuMa, Gαi, and Dynein, which interacts with astral microtubules to rotate the spindle. Cortical Pins/LGN recruitment serves as a critical step in this process. Here, we id…

Decision letter: Correct regionalization of a tissue primordium is essential for coordinated morphogenesis Open

Adam C. Martin · 2021

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract During organ developme…

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis Open

Adam C. Martin, Bob Goldstein · 2021

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates. In recent years, progress…

The nature of cell division forces in epithelial monolayers Open

Vivek Kumar Gupta, Sungmin Nam, Donghyun Yim, Jaclyn Camuglia, Judy Lisette Martin , et al. · 2021

Epithelial cells undergo striking morphological changes during division to ensure proper segregation of genetic and cytoplasmic materials. These morphological changes occur despite dividing cells being mechanically restricted by neighborin…

Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature Open

Marlis Denk-Lobnig, Jan Frederik Totz, Natalie C. Heer, Jörn Dunkel, Adam C. Martin · 2021

During development, gene expression regulates cell mechanics and shape to sculpt tissues. Epithelial folding proceeds through distinct cell shape changes that occur simultaneously in different regions of a tissue. Here, using quantitative …

Actin-based force generation and cell adhesion in tissue morphogenesis Open

D. Nathaniel Clarke, Adam C. Martin · 2021

Dynamics of hydraulic and contractile wave-mediated fluid transport duringDrosophilaoogenesis Open

Jasmin Imran Alsous, Nicolas Romeo, Jonathan A. Jackson, Frank M. Mason, Jörn Dunkel , et al. · 2021

Significance Fluid flow plays an important role during oogenesis. From insects to mice, oocytes mature by acquiring cytoplasm from sister germ cells, yet the biological and physical mechanisms underlying this transport process remain poorl…

The nature of mitotic forces in epithelial monolayers Open

Vivek Kumar Gupta, Sungmin Nam, Jaclyn Camuglia, Judy Lisette Martin, Erin Sanders , et al. · 2020

Epithelial cells undergo striking morphological changes during mitosis to ensure proper segregation of genetic and cytoplasmic materials. These morphological changes occur despite dividing cells being mechanically restricted by neighboring…

Self-organized cytoskeletal alignment duringDrosophilamesoderm invagination Open

Adam C. Martin · 2020

During tissue morphogenesis, mechanical forces are propagated across tissues, resulting in tissue shape changes. These forces in turn can influence cell behaviour, leading to a feedback process that can be described as self-organizing. Her…

Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division Open

Clint S. Ko, Prateek Kalakuntla, Adam C. Martin · 2020

Cell divisions can either promote or inhibit tissue morphogenesis. In contractile epithelia, mitotic entry disrupts medioapical myosin activation and reverses apical constriction. We found that different spatiotemporal patterns of mitotic …

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