Adam C. Retchless
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View article: Household clusters of SARS-CoV-2 Omicron subvariants contemporaneously sequenced from dogs and their owners
Household clusters of SARS-CoV-2 Omicron subvariants contemporaneously sequenced from dogs and their owners Open
Monitoring the zoonotic potential of emerging SARS-CoV-2 variants in animals is a critical tool to protect public health. We conducted a longitudinal study in 47 households reporting people with COVID-19 in Texas from January to July 2022,…
View article: Skilled nursing facility wastewater surveillance: a SARS-CoV-2 and antimicrobial resistance detection pilot study
Skilled nursing facility wastewater surveillance: a SARS-CoV-2 and antimicrobial resistance detection pilot study Open
The purpose of this study was to determine the feasibility of facility-level wastewater surveillance in the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in skilled nursing facility (SNF) wastewater using three …
View article: Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses
Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses Open
View article: Household clusters of SARS-CoV-2 Omicron subvariants contemporaneously sequenced from dogs and their owners
Household clusters of SARS-CoV-2 Omicron subvariants contemporaneously sequenced from dogs and their owners Open
Monitoring the zoonotic potential of emerging SARS-CoV-2 variants in animals is a critical tool to protect public health. We conducted a longitudinal study in 47 households reporting people with COVID-19 in Texas in January-July 2022, duri…
View article: Pediatric Rash Illness Outbreak with Initial Positive Measles Immunoglobulin M Antibody Test Results — American Samoa, March–July 2023
Pediatric Rash Illness Outbreak with Initial Positive Measles Immunoglobulin M Antibody Test Results — American Samoa, March–July 2023 Open
On April 24, 2023, the American Samoa Department of Health (ASDoH) declared a public health emergency amid concern about a possible measles outbreak given low 2-dose vaccination coverage at the time. ASDoH had received two positive measles…
View article: Epidemiologic and Genomic Evidence for Zoonotic Transmission of SARS-CoV-2 among People and Animals on a Michigan Mink Farm, United States, 2020
Epidemiologic and Genomic Evidence for Zoonotic Transmission of SARS-CoV-2 among People and Animals on a Michigan Mink Farm, United States, 2020 Open
Farmed mink are one of few animals in which infection with SARS-CoV-2 has resulted in sustained transmission among a population and spillback from mink to people. In September 2020, mink on a Michigan farm exhibited increased morbidity and…
View article: Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States
Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States Open
View article: One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah
One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah Open
From July–November 2020, mink (Neogale vison) on 12 Utah farms experienced an increase in mortality rates due to confirmed SARS-CoV-2 infection. We conducted epidemiologic investigations on six farms to identify the source of virus introdu…
View article: Benchmark datasets for SARS-CoV-2 surveillance bioinformatics
Benchmark datasets for SARS-CoV-2 surveillance bioinformatics Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spread globally and is being surveilled with an international genome sequencing effort. Surveillance consists of…
View article: Peer Review #3 of "Benchmark datasets for SARS-CoV-2 surveillance bioinformatics (v0.2)"
Peer Review #3 of "Benchmark datasets for SARS-CoV-2 surveillance bioinformatics (v0.2)" Open
one unique dataset representing common sequence failures was obtained by rigorously scrutinizing
View article: Peer Review #3 of "Benchmark datasets for SARS-CoV-2 surveillance bioinformatics (v0.1)"
Peer Review #3 of "Benchmark datasets for SARS-CoV-2 surveillance bioinformatics (v0.1)" Open
one unique dataset representing common sequence failures was obtained by rigorously scrutinizing
View article: Impact of Age and Symptom Development on SARS-CoV-2 Transmission in Households With Children—Maryland, New York, and Utah, August 2020–October 2021
Impact of Age and Symptom Development on SARS-CoV-2 Transmission in Households With Children—Maryland, New York, and Utah, August 2020–October 2021 Open
Background Households are common places for spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated factors associated with household transmission and acquisition of SARS-CoV-2. Methods Households with child…
View article: Invasive Meningococcal Disease Among People Experiencing Homelessness—United States, 2016–2019
Invasive Meningococcal Disease Among People Experiencing Homelessness—United States, 2016–2019 Open
Background Recently, several invasive meningococcal disease (IMD) outbreaks caused by Neisseria meningitidis have occurred among people experiencing homelessness (PEH). However, overall IMD risk among PEH is not well described. We compared…
View article: Antimicrobial Susceptibility Survey of Invasive Haemophilus influenzae in the United States in 2016
Antimicrobial Susceptibility Survey of Invasive Haemophilus influenzae in the United States in 2016 Open
Antibiotics play an important role for the treatment and prevention of invasive Haemophilus influenzae disease. Antimicrobial resistance survey of invasive H. influenzae isolates collected in 2016 showed that the US H. influenzae populatio…
View article: Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021 Open
Household transmission of SARS-CoV-2 from children and adult primary cases to household members was frequent. The risk of secondary infection was similar among child and adult household contacts. Among children, household transmission of S…
View article: Transmission of SARS‐CoV‐2 Delta variant (B.1.617.2) from a fully vaccinated human to a canine in Georgia, July 2021
Transmission of SARS‐CoV‐2 Delta variant (B.1.617.2) from a fully vaccinated human to a canine in Georgia, July 2021 Open
SARS‐CoV‐2 infection has been described in a wide range of species, including domestic animals such as dogs and cats. Illness in dogs is usually self‐limiting, and further diagnostics may not be pursued if clinical signs resolve or they re…
View article: Genomic Insights on Variation Underlying Capsule Expression in Meningococcal Carriage Isolates From University Students, United States, 2015–2016
Genomic Insights on Variation Underlying Capsule Expression in Meningococcal Carriage Isolates From University Students, United States, 2015–2016 Open
In January and February 2015, Neisseria meningitidis serogroup B (NmB) outbreaks occurred at two universities in the United States, and mass vaccination campaigns using MenB vaccines were initiated as part of a public health response. Meni…
View article: Investigation of SARS-CoV-2 Transmission Associated With a Large Indoor Convention — New York City, November–December 2021
Investigation of SARS-CoV-2 Transmission Associated With a Large Indoor Convention — New York City, November–December 2021 Open
During November 19-21, 2021, an indoor convention (event) in New York City (NYC), was attended by approximately 53,000 persons from 52 U.S. jurisdictions and 30 foreign countries. In-person registration for the event began on November 18, …
View article: Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Alpha Variant—United States, 2021
Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Alpha Variant—United States, 2021 Open
Background In Spring 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 (Alpha) became the predominant variant in the United States. Research suggests that Alpha has increased transmissibility compared with non-Alph…
View article: Antimicrobial Susceptibility Survey of Invasive <i>Neisseria meningitidis</i>, United States 2012–2016
Antimicrobial Susceptibility Survey of Invasive <i>Neisseria meningitidis</i>, United States 2012–2016 Open
Background Historically, antimicrobial resistance has been rare in US invasive meningococcal disease cases. Methods Meningococcal isolates (n = 695) were collected through population-based surveillance, 2012–2016, and national surveillance…
View article: Risk Factors for Invasive Meningococcal Disease Belonging to a Novel Urethritis Clade of <i>Neisseria meningitidis</i>—United States, 2013–2017
Risk Factors for Invasive Meningococcal Disease Belonging to a Novel Urethritis Clade of <i>Neisseria meningitidis</i>—United States, 2013–2017 Open
We describe cases of invasive meningococcal disease caused by nongroupable Neisseria meningitidis belonging to a novel phylogenetic clade associated with urethritis. Seven cases were identified, comprising 0.6% of sequenced invasive mening…
View article: Infection With the US<i>Neisseria meningitidis</i>Urethritis Clade Does Not Lower Future Risk of Urethral Gonorrhea
Infection With the US<i>Neisseria meningitidis</i>Urethritis Clade Does Not Lower Future Risk of Urethral Gonorrhea Open
Background Cross-protective immunity between Neisseria meningitidis (Nm) and Neisseria gonorrhoeae (Ng) may inform gonococcal vaccine development. Meningococcal serogroup B (MenB) outer membrane vesicle (OMV) vaccines confer modest protect…
View article: Genomic Surveillance for SARS-CoV-2 Variants Circulating in the United States, December 2020–May 2021
Genomic Surveillance for SARS-CoV-2 Variants Circulating in the United States, December 2020–May 2021 Open
SARS-CoV-2, the virus that causes COVID-19, is constantly mutating, leading to new variants (1). Variants have the potential to affect transmission, disease severity, diagnostics, therapeutics, and natural and vaccine-induced immunity. In …
View article: Using Neisseria meningitidis genomic diversity to inform outbreak strain identification
Using Neisseria meningitidis genomic diversity to inform outbreak strain identification Open
Meningococcal disease is a life-threatening illness caused by the human-restricted bacterium Neisseria meningitidis . Outbreaks in the USA involve at least two cases in an organization or community caused by the same serogroup within three…
View article: Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015–2016
Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015–2016 Open
The impact of serogroup B meningococcal (MenB) vaccines on carriage is not completely understood. Using whole-genome sequencing data, we assessed the diversity and distribution of MenB vaccine antigens (particularly FHbp) among 1,514 menin…
View article: Acquisition of Ciprofloxacin Resistance Among an Expanding Clade of β-Lactamase–Positive, Serogroup Y <i>Neisseria meningitidis</i> in the United States
Acquisition of Ciprofloxacin Resistance Among an Expanding Clade of β-Lactamase–Positive, Serogroup Y <i>Neisseria meningitidis</i> in the United States Open
Background Penicillin and ciprofloxacin are important for invasive meningococcal disease (IMD) management and prevention. IMD cases caused by penicillin- and ciprofloxacin-resistant Neisseria meningitidis containing a ROB-1 β-lactamase gen…
View article: Web-Based Genome Analysis of Bacterial Meningitis Pathogens for Public Health Applications Using the Bacterial Meningitis Genomic Analysis Platform (BMGAP)
Web-Based Genome Analysis of Bacterial Meningitis Pathogens for Public Health Applications Using the Bacterial Meningitis Genomic Analysis Platform (BMGAP) Open
Effective laboratory-based surveillance and public health response to bacterial meningitis depends on timely characterization of bacterial meningitis pathogens. Traditionally, characterizing bacterial meningitis pathogens such as Neisseria…
View article: Full Molecular Typing of Neisseria meningitidis Directly from Clinical Specimens for Outbreak Investigation
Full Molecular Typing of Neisseria meningitidis Directly from Clinical Specimens for Outbreak Investigation Open
Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis worldwide and an occasional cause of meningococcal urethritis. When isolates are unavailable for surveillance or outbreak investigations, molecular characterizati…
View article: Detection of Ciprofloxacin-Resistant, <i>β</i>-Lactamase–Producing <i>Neisseria meningitidis</i> Serogroup Y Isolates — United States, 2019–2020
Detection of Ciprofloxacin-Resistant, <i>β</i>-Lactamase–Producing <i>Neisseria meningitidis</i> Serogroup Y Isolates — United States, 2019–2020 Open
Meningococcal disease is a sudden-onset, life-threatening illness caused by the bacterium Neisseria meningitidis. Prompt empiric antibiotic treatment can reduce morbidity and mortality among patients, and antibiotic prophylaxis can prevent…
View article: Oropharyngeal microbiome of a college population following a meningococcal disease outbreak
Oropharyngeal microbiome of a college population following a meningococcal disease outbreak Open